The RAB3-RIM Pathway Is Essential for the Release of Neuromodulators

Claudia M. Persoon, Rein I. Hoogstraaten, Joris P. Nassal, Jan R.T. van Weering, Pascal S. Kaeser, Ruud F. Toonen*, Matthijs Verhage

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

Abstract

Neurons secrete neuromodulators/neuropeptides from dense-core vesicles (DCVs) by a largely unknown mechanism. Persoon et al. identify RAB3 and RIM1/2 as essential factors. RAB3’s indispensable role is the first distinct feature of DCV secretion as compared to synaptic vesicle secretion.

Original languageEnglish
Pages (from-to)1065-1080.e12
JournalNeuron
Volume104
Issue number6
DOIs
Publication statusPublished - 18 Dec 2019

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