The relationship between severity of Alzheimer's disease and prevalence of comorbid depressive symtoms and depression: A systematic review

Renate Verkaik, Jasper Nuyen, Frano̧is Schellevis, Anneke Francke

Research output: Contribution to journalReview articleAcademicpeer-review

Abstract

Objectives: To gain more insight into the association between severity of Alzheimer's Disease (AD) and prevalence of comborbid depression. Methods: A systematic literature review based on the Cochrane methodology was performed. PubMed, PsychINFO and EMBASE databases were searched for existing studies that fulfilled predefined inclusion criteria. The studies were divided into: (1) those that analysed the association between severity of AD and prevalence of depressive symptoms ('continuous' approach) and (2) those that investigated the association between severity of AD and diagnosed depression ('categorical' approach). The quality of existing studies was rated and the results were synthesized with a best evidence synthesis. Results: Twenty-four studies fulfilled the inclusion criteria. Nineteen reported results for a continuous approach and seven for a categorical approach. Three of the four high quality studies within the continuous approach did not find a significant association between severity of AD and prevalence of depressive symptoms. None of the three high quality studies using the categorical approach found a significant association between the severity of AD and the prevalence of diagnosed depression. Conclusions: There is evidence for a lack of association between the severity of AD and the prevalence of comorbid depressive symptoms or diagnosed depression. Until new studies contradict this conclusion, prevention and intervention strategies for comorbid depression in AD should be aimed at all patients irrespective their disease severity.

Original languageEnglish
Pages (from-to)1063-1086
Number of pages24
JournalInternational Journal of Geriatric Psychiatry
Volume22
Issue number11
DOIs
Publication statusPublished - 1 Nov 2007

Cite this

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title = "The relationship between severity of Alzheimer's disease and prevalence of comorbid depressive symtoms and depression: A systematic review",
abstract = "Objectives: To gain more insight into the association between severity of Alzheimer's Disease (AD) and prevalence of comborbid depression. Methods: A systematic literature review based on the Cochrane methodology was performed. PubMed, PsychINFO and EMBASE databases were searched for existing studies that fulfilled predefined inclusion criteria. The studies were divided into: (1) those that analysed the association between severity of AD and prevalence of depressive symptoms ('continuous' approach) and (2) those that investigated the association between severity of AD and diagnosed depression ('categorical' approach). The quality of existing studies was rated and the results were synthesized with a best evidence synthesis. Results: Twenty-four studies fulfilled the inclusion criteria. Nineteen reported results for a continuous approach and seven for a categorical approach. Three of the four high quality studies within the continuous approach did not find a significant association between severity of AD and prevalence of depressive symptoms. None of the three high quality studies using the categorical approach found a significant association between the severity of AD and the prevalence of diagnosed depression. Conclusions: There is evidence for a lack of association between the severity of AD and the prevalence of comorbid depressive symptoms or diagnosed depression. Until new studies contradict this conclusion, prevention and intervention strategies for comorbid depression in AD should be aimed at all patients irrespective their disease severity.",
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The relationship between severity of Alzheimer's disease and prevalence of comorbid depressive symtoms and depression : A systematic review. / Verkaik, Renate; Nuyen, Jasper; Schellevis, Frano̧is; Francke, Anneke.

In: International Journal of Geriatric Psychiatry, Vol. 22, No. 11, 01.11.2007, p. 1063-1086.

Research output: Contribution to journalReview articleAcademicpeer-review

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