TY - JOUR
T1 - The risk of hypogonadism after testicular sperm extraction in men with various types of azoospermia
T2 - a prospective cohort study
AU - Eliveld, Jitske
AU - van der Bles, Ilias
AU - van Wely, Madelon
AU - Meißner, Andreas
AU - Soufan, Alexandre T.
AU - Heijboer, Annemieke C.
AU - Repping, Sjoerd
AU - van der Veen, Fulco
AU - van Pelt, Ans M. M.
N1 - Funding Information:
This research was funded by Amsterdam UMC .
Publisher Copyright:
© 2023 The Author(s)
PY - 2023
Y1 - 2023
N2 - Research question: What is the risk of hypogonadism in men with obstructive azoospermia, non-obstructive azoospermia (NOA) or Klinefelter syndrome after testicular sperm extraction (TESE)? Design: This prospective longitudinal cohort study was carried out between 2007 and 2015. Results: Around 36% of men with Klinefelter syndrome, 4% of men with obstructive azoospermia and 3% of men with NOA needed testosterone replacement therapy (TRT). Klinefelter syndrome was strongly associated with TRT while no association was found between obstructive azoospermia or NOA and TRT. Irrespective of the pre-operative diagnosis, a higher testosterone concentration before TESE was associated with a lower chance of needing TRT. Conclusions: Men with obstructive azoospermia or NOA have a similar moderate risk of clinical hypogonadism after TESE, while this risk is much larger for men with Klinefelter syndrome. The risk of clinical hypogonadism is lower when testosterone concentrations are high before TESE.
AB - Research question: What is the risk of hypogonadism in men with obstructive azoospermia, non-obstructive azoospermia (NOA) or Klinefelter syndrome after testicular sperm extraction (TESE)? Design: This prospective longitudinal cohort study was carried out between 2007 and 2015. Results: Around 36% of men with Klinefelter syndrome, 4% of men with obstructive azoospermia and 3% of men with NOA needed testosterone replacement therapy (TRT). Klinefelter syndrome was strongly associated with TRT while no association was found between obstructive azoospermia or NOA and TRT. Irrespective of the pre-operative diagnosis, a higher testosterone concentration before TESE was associated with a lower chance of needing TRT. Conclusions: Men with obstructive azoospermia or NOA have a similar moderate risk of clinical hypogonadism after TESE, while this risk is much larger for men with Klinefelter syndrome. The risk of clinical hypogonadism is lower when testosterone concentrations are high before TESE.
KW - Hypogonadism
KW - Klinefelter syndrome
KW - Non-obstructive azoospermia
KW - Obstructive azoospermia
KW - Testicular sperm extraction
KW - Testosterone
UR - https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85151237532&origin=inward
UR - https://www.ncbi.nlm.nih.gov/pubmed/37005152
U2 - 10.1016/j.rbmo.2023.02.003
DO - 10.1016/j.rbmo.2023.02.003
M3 - Article
C2 - 37005152
SN - 1472-6483
VL - 46
SP - 973
EP - 981
JO - Reproductive BioMedicine Online
JF - Reproductive BioMedicine Online
IS - 6
ER -