Abstract

In the last 10 years the continuing search for gene function has yielded many mutant mice that unexpectedly showed a complete lack of lymph nodes and/or Peyer's patches. With the realization that all these functionally highly diverse genes are involved at some point in the development of lymphoid organs, the challenge now is to assign a function to the molecules involved in lymphoid organ development. It will be important to determine the sequence of molecular events and assign this to the cellular events that lead to an accumulation of hematopoietic cells in one location, ultimately forming an organized lymphoid organ. Here we will focus on CD45+CD4+CD3- cells that are the early colonizing cells in lymph nodes and Peyer's patches and develop a hypothetical model of their contribution to the creation of organized lymphoid structures.

Original languageEnglish
Pages (from-to)41-50
Number of pages10
JournalImmunological Reviews
Volume189
Publication statusPublished - Nov 2002

Cite this

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title = "The role of CD45+CD4+CD3- cells in lymphoid organ development",
abstract = "In the last 10 years the continuing search for gene function has yielded many mutant mice that unexpectedly showed a complete lack of lymph nodes and/or Peyer's patches. With the realization that all these functionally highly diverse genes are involved at some point in the development of lymphoid organs, the challenge now is to assign a function to the molecules involved in lymphoid organ development. It will be important to determine the sequence of molecular events and assign this to the cellular events that lead to an accumulation of hematopoietic cells in one location, ultimately forming an organized lymphoid organ. Here we will focus on CD45+CD4+CD3- cells that are the early colonizing cells in lymph nodes and Peyer's patches and develop a hypothetical model of their contribution to the creation of organized lymphoid structures.",
keywords = "Animals, CD3 Complex/metabolism, CD4-Positive T-Lymphocytes/cytology, Carrier Proteins/immunology, Fetus/cytology, Gene Expression Regulation, Developmental, Humans, Leukocyte Common Antigens/metabolism, Liver/cytology, Lymph Nodes/cytology, Lymphatic System/cytology, Membrane Glycoproteins/immunology, Mice, Mice, Mutant Strains, Models, Immunological, Peyer's Patches/cytology, RANK Ligand, Receptor Activator of Nuclear Factor-kappa B, T-Lymphocyte Subsets/cytology",
author = "Tom Cupedo and Georg Kraal and Mebius, {Reina E}",
year = "2002",
month = "11",
language = "English",
volume = "189",
pages = "41--50",
journal = "Immunological Reviews",
issn = "0105-2896",
publisher = "Wiley-Blackwell",

}

The role of CD45+CD4+CD3- cells in lymphoid organ development. / Cupedo, Tom; Kraal, Georg; Mebius, Reina E.

In: Immunological Reviews, Vol. 189, 11.2002, p. 41-50.

Research output: Contribution to journalReview articleAcademicpeer-review

TY - JOUR

T1 - The role of CD45+CD4+CD3- cells in lymphoid organ development

AU - Cupedo, Tom

AU - Kraal, Georg

AU - Mebius, Reina E

PY - 2002/11

Y1 - 2002/11

N2 - In the last 10 years the continuing search for gene function has yielded many mutant mice that unexpectedly showed a complete lack of lymph nodes and/or Peyer's patches. With the realization that all these functionally highly diverse genes are involved at some point in the development of lymphoid organs, the challenge now is to assign a function to the molecules involved in lymphoid organ development. It will be important to determine the sequence of molecular events and assign this to the cellular events that lead to an accumulation of hematopoietic cells in one location, ultimately forming an organized lymphoid organ. Here we will focus on CD45+CD4+CD3- cells that are the early colonizing cells in lymph nodes and Peyer's patches and develop a hypothetical model of their contribution to the creation of organized lymphoid structures.

AB - In the last 10 years the continuing search for gene function has yielded many mutant mice that unexpectedly showed a complete lack of lymph nodes and/or Peyer's patches. With the realization that all these functionally highly diverse genes are involved at some point in the development of lymphoid organs, the challenge now is to assign a function to the molecules involved in lymphoid organ development. It will be important to determine the sequence of molecular events and assign this to the cellular events that lead to an accumulation of hematopoietic cells in one location, ultimately forming an organized lymphoid organ. Here we will focus on CD45+CD4+CD3- cells that are the early colonizing cells in lymph nodes and Peyer's patches and develop a hypothetical model of their contribution to the creation of organized lymphoid structures.

KW - Animals

KW - CD3 Complex/metabolism

KW - CD4-Positive T-Lymphocytes/cytology

KW - Carrier Proteins/immunology

KW - Fetus/cytology

KW - Gene Expression Regulation, Developmental

KW - Humans

KW - Leukocyte Common Antigens/metabolism

KW - Liver/cytology

KW - Lymph Nodes/cytology

KW - Lymphatic System/cytology

KW - Membrane Glycoproteins/immunology

KW - Mice

KW - Mice, Mutant Strains

KW - Models, Immunological

KW - Peyer's Patches/cytology

KW - RANK Ligand

KW - Receptor Activator of Nuclear Factor-kappa B

KW - T-Lymphocyte Subsets/cytology

M3 - Review article

VL - 189

SP - 41

EP - 50

JO - Immunological Reviews

JF - Immunological Reviews

SN - 0105-2896

ER -