The role of cognitive functioning in the relationship between childhood trauma and a mixed phenotype of affective-anxious-psychotic symptoms in psychotic disorders

Group Investigators

Research output: Contribution to journalArticleAcademicpeer-review

Abstract

Cognitive impairments in patients with psychotic disorder have been associated with poor functioning and increased symptom severity. Furthermore, childhood trauma (CT) exposure has been associated with worse cognitive functioning as well as co-occurrence of affective-anxious-psychosis symptoms or a ‘mixed phenotype of psychopathology’ (MP), which in turn is associated with greater symptom severity, and poor functioning. This study aims to evaluate if cognition could be associated with CT/MP. 532 patients with non-affective psychotic patients were assessed on CT, symptom profile, cognition, functioning, and symptom severity at baseline and 3 and 6-year follow-up. Four subgroups were made according to trauma exposure (CT − or CT +) and presence of a mixed phenotype (MP − or MP +): CT −/MP (n = 272), CT −/MP + (n = 157), CT +/MP − (n = 49), and CT +/MP + (n = 54). Mixed-effects multilevel regression, linear regression, and Tobit analyses were performed. Patients with both CT and MP showed lower verbal learning and memory than CT −/MP + individuals (p < 0.001). No other significant differences were found among the 4 subgroups. No cognitive decline was found at follow-up, neither in the CT +/MP − nor in CT −/MP − group. Lower cognition was not associated with increased symptom severity or poor functioning at follow-up, neither in the CT +/MP − nor in CT −/MP − group. Although cognitive impairments and CT may be related to clinical or functional features of psychotic disorder, and cognitive functioning could be affected by CT exposure, cognition does not discriminate subgroups of patients stratified by CT exposure and MP.
Original languageEnglish
Pages (from-to)262-268
JournalSchizophrenia Research
Volume192
DOIs
Publication statusPublished - 2018
Externally publishedYes

Cite this

@article{0d261e7ceaa34c8caa0b7c5f8075b185,
title = "The role of cognitive functioning in the relationship between childhood trauma and a mixed phenotype of affective-anxious-psychotic symptoms in psychotic disorders",
abstract = "Cognitive impairments in patients with psychotic disorder have been associated with poor functioning and increased symptom severity. Furthermore, childhood trauma (CT) exposure has been associated with worse cognitive functioning as well as co-occurrence of affective-anxious-psychosis symptoms or a ‘mixed phenotype of psychopathology’ (MP), which in turn is associated with greater symptom severity, and poor functioning. This study aims to evaluate if cognition could be associated with CT/MP. 532 patients with non-affective psychotic patients were assessed on CT, symptom profile, cognition, functioning, and symptom severity at baseline and 3 and 6-year follow-up. Four subgroups were made according to trauma exposure (CT − or CT +) and presence of a mixed phenotype (MP − or MP +): CT −/MP (n = 272), CT −/MP + (n = 157), CT +/MP − (n = 49), and CT +/MP + (n = 54). Mixed-effects multilevel regression, linear regression, and Tobit analyses were performed. Patients with both CT and MP showed lower verbal learning and memory than CT −/MP + individuals (p < 0.001). No other significant differences were found among the 4 subgroups. No cognitive decline was found at follow-up, neither in the CT +/MP − nor in CT −/MP − group. Lower cognition was not associated with increased symptom severity or poor functioning at follow-up, neither in the CT +/MP − nor in CT −/MP − group. Although cognitive impairments and CT may be related to clinical or functional features of psychotic disorder, and cognitive functioning could be affected by CT exposure, cognition does not discriminate subgroups of patients stratified by CT exposure and MP.",
author = "{Group Investigators} and Giovanni Mansueto and {van Nierop}, Martine and Koen Schruers and Alizadeh, {Berhooz Z.} and Bartels-Velthuis, {Agna A.} and {van Beveren}, {Nico J.} and Richard Bruggeman and Wiepke Cahn and {de Haan}, Lieuwe and Philippe Delespaul and Meijer, {Carin J.} and Inez Myin-Germeys and Kahn, {Rene S.} and Frederike Schirmbeck and Simons, {Claudia J. P.} and {van Haren}, {Neeltje E. M.} and {van Os}, Jim and {van Winkel}, Ruud",
year = "2018",
doi = "10.1016/j.schres.2017.04.003",
language = "English",
volume = "192",
pages = "262--268",
journal = "Schizophrenia Research",
issn = "0920-9964",
publisher = "Elsevier",

}

The role of cognitive functioning in the relationship between childhood trauma and a mixed phenotype of affective-anxious-psychotic symptoms in psychotic disorders. / Group Investigators.

In: Schizophrenia Research, Vol. 192, 2018, p. 262-268.

Research output: Contribution to journalArticleAcademicpeer-review

TY - JOUR

T1 - The role of cognitive functioning in the relationship between childhood trauma and a mixed phenotype of affective-anxious-psychotic symptoms in psychotic disorders

AU - Group Investigators

AU - Mansueto, Giovanni

AU - van Nierop, Martine

AU - Schruers, Koen

AU - Alizadeh, Berhooz Z.

AU - Bartels-Velthuis, Agna A.

AU - van Beveren, Nico J.

AU - Bruggeman, Richard

AU - Cahn, Wiepke

AU - de Haan, Lieuwe

AU - Delespaul, Philippe

AU - Meijer, Carin J.

AU - Myin-Germeys, Inez

AU - Kahn, Rene S.

AU - Schirmbeck, Frederike

AU - Simons, Claudia J. P.

AU - van Haren, Neeltje E. M.

AU - van Os, Jim

AU - van Winkel, Ruud

PY - 2018

Y1 - 2018

N2 - Cognitive impairments in patients with psychotic disorder have been associated with poor functioning and increased symptom severity. Furthermore, childhood trauma (CT) exposure has been associated with worse cognitive functioning as well as co-occurrence of affective-anxious-psychosis symptoms or a ‘mixed phenotype of psychopathology’ (MP), which in turn is associated with greater symptom severity, and poor functioning. This study aims to evaluate if cognition could be associated with CT/MP. 532 patients with non-affective psychotic patients were assessed on CT, symptom profile, cognition, functioning, and symptom severity at baseline and 3 and 6-year follow-up. Four subgroups were made according to trauma exposure (CT − or CT +) and presence of a mixed phenotype (MP − or MP +): CT −/MP (n = 272), CT −/MP + (n = 157), CT +/MP − (n = 49), and CT +/MP + (n = 54). Mixed-effects multilevel regression, linear regression, and Tobit analyses were performed. Patients with both CT and MP showed lower verbal learning and memory than CT −/MP + individuals (p < 0.001). No other significant differences were found among the 4 subgroups. No cognitive decline was found at follow-up, neither in the CT +/MP − nor in CT −/MP − group. Lower cognition was not associated with increased symptom severity or poor functioning at follow-up, neither in the CT +/MP − nor in CT −/MP − group. Although cognitive impairments and CT may be related to clinical or functional features of psychotic disorder, and cognitive functioning could be affected by CT exposure, cognition does not discriminate subgroups of patients stratified by CT exposure and MP.

AB - Cognitive impairments in patients with psychotic disorder have been associated with poor functioning and increased symptom severity. Furthermore, childhood trauma (CT) exposure has been associated with worse cognitive functioning as well as co-occurrence of affective-anxious-psychosis symptoms or a ‘mixed phenotype of psychopathology’ (MP), which in turn is associated with greater symptom severity, and poor functioning. This study aims to evaluate if cognition could be associated with CT/MP. 532 patients with non-affective psychotic patients were assessed on CT, symptom profile, cognition, functioning, and symptom severity at baseline and 3 and 6-year follow-up. Four subgroups were made according to trauma exposure (CT − or CT +) and presence of a mixed phenotype (MP − or MP +): CT −/MP (n = 272), CT −/MP + (n = 157), CT +/MP − (n = 49), and CT +/MP + (n = 54). Mixed-effects multilevel regression, linear regression, and Tobit analyses were performed. Patients with both CT and MP showed lower verbal learning and memory than CT −/MP + individuals (p < 0.001). No other significant differences were found among the 4 subgroups. No cognitive decline was found at follow-up, neither in the CT +/MP − nor in CT −/MP − group. Lower cognition was not associated with increased symptom severity or poor functioning at follow-up, neither in the CT +/MP − nor in CT −/MP − group. Although cognitive impairments and CT may be related to clinical or functional features of psychotic disorder, and cognitive functioning could be affected by CT exposure, cognition does not discriminate subgroups of patients stratified by CT exposure and MP.

UR - https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85017409457&origin=inward

UR - https://www.ncbi.nlm.nih.gov/pubmed/28416093

U2 - 10.1016/j.schres.2017.04.003

DO - 10.1016/j.schres.2017.04.003

M3 - Article

VL - 192

SP - 262

EP - 268

JO - Schizophrenia Research

JF - Schizophrenia Research

SN - 0920-9964

ER -