TY - JOUR
T1 - The role of microRNAs in skeletal muscle health and disease
AU - Kirby, Tyler J
AU - Chaillou, Thomas
AU - McCarthy, John J
PY - 2015/1/1
Y1 - 2015/1/1
N2 - Over the last decade non-coding RNAs have emerged as importance regulators of gene expression. In particular, microRNAs are a class of small RNAs of ∼ 22 nucleotides that repress gene expression through a post-transcriptional mechanism. MicroRNAs have been shown to be involved in a broader range of biological processes, both physiological and pathological, including myogenesis, adaptation to exercise and various myopathies. The purpose of this review is to provide a comprehensive summary of what is currently known about the role of microRNAs in skeletal muscle health and disease.
AB - Over the last decade non-coding RNAs have emerged as importance regulators of gene expression. In particular, microRNAs are a class of small RNAs of ∼ 22 nucleotides that repress gene expression through a post-transcriptional mechanism. MicroRNAs have been shown to be involved in a broader range of biological processes, both physiological and pathological, including myogenesis, adaptation to exercise and various myopathies. The purpose of this review is to provide a comprehensive summary of what is currently known about the role of microRNAs in skeletal muscle health and disease.
KW - Humans
KW - MicroRNAs/physiology
KW - Muscle Development/physiology
KW - Muscle, Skeletal/physiology
KW - Muscular Atrophy/physiopathology
KW - Muscular Diseases/physiopathology
U2 - 10.2741/4298
DO - 10.2741/4298
M3 - Review article
C2 - 25553440
VL - 20
SP - 37
EP - 77
JO - Frontiers in bioscience (Landmark edition)
JF - Frontiers in bioscience (Landmark edition)
SN - 1093-4715
ER -