The role of the microbiome in cancer and therapy efficacy: Focus on lung cancer

Adrienne Halley, Alessandro Leonetti, Alessandro Gregori, Marcello Tiseo, Dong M.E.I. Deng, Elisa Giovannetti, Godefridus J. Peters

Research output: Contribution to journalReview articleAcademicpeer-review

Abstract

The microbiome is extremely important for human health; more recently its role in the context of cancer became clear. Microbial effects range from enhancing cancer immunity and cancer therapy efficacy, to promoting cancer progression and inhibiting treatment efficacy. These broad implications led researchers to investigate these specific interactions, as well as how modification of the microbiome can improve cancer survival and treatment efficacy. While these interactions are better established for cancers such as gastric cancer, they are far less understood in others. As non-small cell lung cancer (NSCLC) makes up the majority of lung cancer cases, and is among the top causes of cancer deaths worldwide, understanding the mechanisms by which the microbiome may impact progression and treatment is crucial to improve patient survival and treatment response. A literature review was conducted to reveal the crosslink between human microbiome and lung cancer. This includes immune priming, induction of pro- or anti-tumor response,

Original languageEnglish
Pages (from-to)4807-4818
Number of pages12
JournalAnticancer Research
Volume40
Issue number9
DOIs
Publication statusPublished - Sep 2020

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