The second human βB2-crystallin gene is a pseudogene

R. H. Brakenhoff; H. J.M. Aarts; F. Schuren; N. H. Lubsen; J. G.G. Schoenmakers

doi:10.1016/0014-4835(92)90036-R

The second human βB₂-crystallin gene is a pseudogene

R. H. Brakenhoff, H. J.M. Aarts, F. Schuren, N. H. Lubsen, J. G.G. Schoenmakers^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

Comparison of the partial sequences of the human βB₂-1- and βB₂-2-crystallin genes with orthologous rat or calf sequences shows that the fourth exon sequence of the human βB₂-2 gene contains a one triplet deletion and a mutated splice acceptor site. No transcripts from the βB₂-2-crystallin gene could be detected in the human lens. These data suggest that the human βB₂-2-crystallin gene is a pseudogene.

Original language	English
Pages (from-to)	803-806
Number of pages	4
Journal	Experimental Eye Research
Volume	54
Issue number	5
DOIs	https://doi.org/10.1016/0014-4835(92)90036-R
Publication status	Published - May 1992

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title = "The second human βB2-crystallin gene is a pseudogene",

abstract = "Comparison of the partial sequences of the human βB2-1- and βB2-2-crystallin genes with orthologous rat or calf sequences shows that the fourth exon sequence of the human βB2-2 gene contains a one triplet deletion and a mutated splice acceptor site. No transcripts from the βB2-2-crystallin gene could be detected in the human lens. These data suggest that the human βB2-2-crystallin gene is a pseudogene.",

keywords = "lens/splice site mutation",

author = "Brakenhoff, {R. H.} and Aarts, {H. J.M.} and F. Schuren and Lubsen, {N. H.} and Schoenmakers, {J. G.G.}",

year = "1992",

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T1 - The second human βB2-crystallin gene is a pseudogene

AU - Brakenhoff, R. H.

AU - Aarts, H. J.M.

AU - Schuren, F.

AU - Lubsen, N. H.

AU - Schoenmakers, J. G.G.

PY - 1992/5

Y1 - 1992/5

N2 - Comparison of the partial sequences of the human βB2-1- and βB2-2-crystallin genes with orthologous rat or calf sequences shows that the fourth exon sequence of the human βB2-2 gene contains a one triplet deletion and a mutated splice acceptor site. No transcripts from the βB2-2-crystallin gene could be detected in the human lens. These data suggest that the human βB2-2-crystallin gene is a pseudogene.

AB - Comparison of the partial sequences of the human βB2-1- and βB2-2-crystallin genes with orthologous rat or calf sequences shows that the fourth exon sequence of the human βB2-2 gene contains a one triplet deletion and a mutated splice acceptor site. No transcripts from the βB2-2-crystallin gene could be detected in the human lens. These data suggest that the human βB2-2-crystallin gene is a pseudogene.

KW - lens/splice site mutation

UR - http://www.scopus.com/inward/record.url?scp=0026659266&partnerID=8YFLogxK

U2 - 10.1016/0014-4835(92)90036-R

DO - 10.1016/0014-4835(92)90036-R

M3 - Article

C2 - 1623966

AN - SCOPUS:0026659266

VL - 54

SP - 803

EP - 806

JO - Experimental Eye Research

JF - Experimental Eye Research

SN - 0014-4835

IS - 5

ER -

The second human βB2-crystallin gene is a pseudogene

Abstract

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The second human βB₂-crystallin gene is a pseudogene