The structural connectome of children with traumatic brain injury

Marsh Königs, L. W.Ernest van Heurn, Roel Bakx, R. Jeroen Vermeulen, J. Carel Goslings, Bwee Tien Poll-The, Marleen van der Wees, Coriene E. Catsman-Berrevoets, Jaap Oosterlaan, Petra J.W. Pouwels

Research output: Contribution to journalArticleAcademicpeer-review

Abstract

This study aimed to investigate the impact of mild to severe pediatric TBI on the structural connectome. Children aged 8-14 years with trauma control (TC) injury (n = 27) were compared to children with mild TBI and risk factors for complicated TBI (mildRF+, n = 20) or moderate/severe TBI (n=16) at 2.8 years post-injury. Probabilistic tractography on diffusion tensor imaging data was used in combination with graph theory to study structural connectivity. Functional outcome was measured using neurocognitive tests and parent and teacher questionnaires for behavioral functioning. The results revealed no evidence for an impact of mildRF+ TBI on the structural connectome. In contrast, the moderate/severe TBI group showed longer characteristic path length (P=0.022, d=0.82) than the TC group. Furthermore, longer characteristic path length was related to poorer intelligence and poorer working memory in children with TBI. In conclusion, children have abnormal organization of the structural connectome after moderate/severe TBI, which may be implicated in neurocognitive dysfunction associated with pediatric TBI. These findings should be interpreted in the context of our exploratory analyses, which indicate that the definition and weighting of connectivity (e.g., streamline density, fractional anisotropy) influence the properties of the reconstructed connectome and its sensitivity to the impact and outcome of pediatric TBI.

Original languageEnglish
JournalHuman Brain Mapping
DOIs
Publication statusAccepted/In press - 2017

Cite this

Königs, Marsh ; van Heurn, L. W.Ernest ; Bakx, Roel ; Vermeulen, R. Jeroen ; Goslings, J. Carel ; Poll-The, Bwee Tien ; van der Wees, Marleen ; Catsman-Berrevoets, Coriene E. ; Oosterlaan, Jaap ; Pouwels, Petra J.W. / The structural connectome of children with traumatic brain injury. In: Human Brain Mapping. 2017.
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abstract = "This study aimed to investigate the impact of mild to severe pediatric TBI on the structural connectome. Children aged 8-14 years with trauma control (TC) injury (n = 27) were compared to children with mild TBI and risk factors for complicated TBI (mildRF+, n = 20) or moderate/severe TBI (n=16) at 2.8 years post-injury. Probabilistic tractography on diffusion tensor imaging data was used in combination with graph theory to study structural connectivity. Functional outcome was measured using neurocognitive tests and parent and teacher questionnaires for behavioral functioning. The results revealed no evidence for an impact of mildRF+ TBI on the structural connectome. In contrast, the moderate/severe TBI group showed longer characteristic path length (P=0.022, d=0.82) than the TC group. Furthermore, longer characteristic path length was related to poorer intelligence and poorer working memory in children with TBI. In conclusion, children have abnormal organization of the structural connectome after moderate/severe TBI, which may be implicated in neurocognitive dysfunction associated with pediatric TBI. These findings should be interpreted in the context of our exploratory analyses, which indicate that the definition and weighting of connectivity (e.g., streamline density, fractional anisotropy) influence the properties of the reconstructed connectome and its sensitivity to the impact and outcome of pediatric TBI.",
keywords = "Functional outcome, Pediatrics, Structural connectivity, Traumatic brain injury",
author = "Marsh K{\"o}nigs and {van Heurn}, {L. W.Ernest} and Roel Bakx and Vermeulen, {R. Jeroen} and Goslings, {J. Carel} and Poll-The, {Bwee Tien} and {van der Wees}, Marleen and Catsman-Berrevoets, {Coriene E.} and Jaap Oosterlaan and Pouwels, {Petra J.W.}",
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language = "English",
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Königs, M, van Heurn, LWE, Bakx, R, Vermeulen, RJ, Goslings, JC, Poll-The, BT, van der Wees, M, Catsman-Berrevoets, CE, Oosterlaan, J & Pouwels, PJW 2017, 'The structural connectome of children with traumatic brain injury' Human Brain Mapping. https://doi.org/10.1002/hbm.23614

The structural connectome of children with traumatic brain injury. / Königs, Marsh; van Heurn, L. W.Ernest; Bakx, Roel; Vermeulen, R. Jeroen; Goslings, J. Carel; Poll-The, Bwee Tien; van der Wees, Marleen; Catsman-Berrevoets, Coriene E.; Oosterlaan, Jaap; Pouwels, Petra J.W.

In: Human Brain Mapping, 2017.

Research output: Contribution to journalArticleAcademicpeer-review

TY - JOUR

T1 - The structural connectome of children with traumatic brain injury

AU - Königs, Marsh

AU - van Heurn, L. W.Ernest

AU - Bakx, Roel

AU - Vermeulen, R. Jeroen

AU - Goslings, J. Carel

AU - Poll-The, Bwee Tien

AU - van der Wees, Marleen

AU - Catsman-Berrevoets, Coriene E.

AU - Oosterlaan, Jaap

AU - Pouwels, Petra J.W.

PY - 2017

Y1 - 2017

N2 - This study aimed to investigate the impact of mild to severe pediatric TBI on the structural connectome. Children aged 8-14 years with trauma control (TC) injury (n = 27) were compared to children with mild TBI and risk factors for complicated TBI (mildRF+, n = 20) or moderate/severe TBI (n=16) at 2.8 years post-injury. Probabilistic tractography on diffusion tensor imaging data was used in combination with graph theory to study structural connectivity. Functional outcome was measured using neurocognitive tests and parent and teacher questionnaires for behavioral functioning. The results revealed no evidence for an impact of mildRF+ TBI on the structural connectome. In contrast, the moderate/severe TBI group showed longer characteristic path length (P=0.022, d=0.82) than the TC group. Furthermore, longer characteristic path length was related to poorer intelligence and poorer working memory in children with TBI. In conclusion, children have abnormal organization of the structural connectome after moderate/severe TBI, which may be implicated in neurocognitive dysfunction associated with pediatric TBI. These findings should be interpreted in the context of our exploratory analyses, which indicate that the definition and weighting of connectivity (e.g., streamline density, fractional anisotropy) influence the properties of the reconstructed connectome and its sensitivity to the impact and outcome of pediatric TBI.

AB - This study aimed to investigate the impact of mild to severe pediatric TBI on the structural connectome. Children aged 8-14 years with trauma control (TC) injury (n = 27) were compared to children with mild TBI and risk factors for complicated TBI (mildRF+, n = 20) or moderate/severe TBI (n=16) at 2.8 years post-injury. Probabilistic tractography on diffusion tensor imaging data was used in combination with graph theory to study structural connectivity. Functional outcome was measured using neurocognitive tests and parent and teacher questionnaires for behavioral functioning. The results revealed no evidence for an impact of mildRF+ TBI on the structural connectome. In contrast, the moderate/severe TBI group showed longer characteristic path length (P=0.022, d=0.82) than the TC group. Furthermore, longer characteristic path length was related to poorer intelligence and poorer working memory in children with TBI. In conclusion, children have abnormal organization of the structural connectome after moderate/severe TBI, which may be implicated in neurocognitive dysfunction associated with pediatric TBI. These findings should be interpreted in the context of our exploratory analyses, which indicate that the definition and weighting of connectivity (e.g., streamline density, fractional anisotropy) influence the properties of the reconstructed connectome and its sensitivity to the impact and outcome of pediatric TBI.

KW - Functional outcome

KW - Pediatrics

KW - Structural connectivity

KW - Traumatic brain injury

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U2 - 10.1002/hbm.23614

DO - 10.1002/hbm.23614

M3 - Article

JO - Human Brain Mapping

JF - Human Brain Mapping

SN - 1065-9471

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