The trichodysplasia spinulosa-associated polyomavirus: Virological background and clinical implications

Siamaque Kazem, Els van der Meijden, Mariet C.W. Feltkamp

Research output: Contribution to journalReview articleAcademicpeer-review

Abstract

Trichodysplasia spinulosa-associated polyomavirus (TSPyV) is a new species of the family Polyomaviridae that was discovered in 2010. TSPyV infects humans and is associated with the development of a rare disease called trichodysplasia spinulosa. Trichodysplasia spinulosa is a skin disease of severely immunocompromised hosts characterized by follicular distention and keratotic spine formation especially on the face. Electron microscopy, immunohistochemistry, and viral load measurements indicate an etiological role of active TSPyV infection in the development of this disease. This review will address virological and pathogenic properties of TSPyV, as well as epidemiologic, diagnostic, and therapeutic aspects of TSPyV infection.

Original languageEnglish
Pages (from-to)770-782
Number of pages13
JournalAPMIS
Volume121
Issue number8
DOIs
Publication statusPublished - 1 Aug 2013

Cite this

Kazem, Siamaque ; van der Meijden, Els ; Feltkamp, Mariet C.W. / The trichodysplasia spinulosa-associated polyomavirus : Virological background and clinical implications. In: APMIS. 2013 ; Vol. 121, No. 8. pp. 770-782.
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abstract = "Trichodysplasia spinulosa-associated polyomavirus (TSPyV) is a new species of the family Polyomaviridae that was discovered in 2010. TSPyV infects humans and is associated with the development of a rare disease called trichodysplasia spinulosa. Trichodysplasia spinulosa is a skin disease of severely immunocompromised hosts characterized by follicular distention and keratotic spine formation especially on the face. Electron microscopy, immunohistochemistry, and viral load measurements indicate an etiological role of active TSPyV infection in the development of this disease. This review will address virological and pathogenic properties of TSPyV, as well as epidemiologic, diagnostic, and therapeutic aspects of TSPyV infection.",
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The trichodysplasia spinulosa-associated polyomavirus : Virological background and clinical implications. / Kazem, Siamaque; van der Meijden, Els; Feltkamp, Mariet C.W.

In: APMIS, Vol. 121, No. 8, 01.08.2013, p. 770-782.

Research output: Contribution to journalReview articleAcademicpeer-review

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T1 - The trichodysplasia spinulosa-associated polyomavirus

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AU - Kazem, Siamaque

AU - van der Meijden, Els

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AB - Trichodysplasia spinulosa-associated polyomavirus (TSPyV) is a new species of the family Polyomaviridae that was discovered in 2010. TSPyV infects humans and is associated with the development of a rare disease called trichodysplasia spinulosa. Trichodysplasia spinulosa is a skin disease of severely immunocompromised hosts characterized by follicular distention and keratotic spine formation especially on the face. Electron microscopy, immunohistochemistry, and viral load measurements indicate an etiological role of active TSPyV infection in the development of this disease. This review will address virological and pathogenic properties of TSPyV, as well as epidemiologic, diagnostic, and therapeutic aspects of TSPyV infection.

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