The use of host cell DNA methylation analysis in the detection and management of women with advanced cervical intraepithelial neoplasia: a review

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Abstract

This paper briefly reviews the role of hypermethylation of host cell genes in cervical carcinogenesis and discusses potential clinical applications of methylation analysis in the management of high-risk HPV (hrHPV) -positive women. We argue that methylation assays can be used: 1. for primary triage of hrHPV-positive women to detect cervical cancer and advanced cervical intraepithelial neoplasia (CIN); 2. as secondary triage for women with minor cytological abnormalities to identify those with the highest risk of CIN3 or worse; 3. as exit test for women leaving the screening programme to identify cervical cancer and advanced CIN; and 4. to support management of CIN. Tweetable abstract: This paper discusses potential clinical applications of DNA methylation analysis in the management of women with a high-risk HPV infection.

Original languageEnglish
Pages (from-to)504-514
Number of pages11
JournalBJOG: An International Journal of Obstetrics & Gynaecology
Volume128
Issue number3
Early online date3 Jul 2020
DOIs
Publication statusPublished - Feb 2021

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