This paper briefly reviews the role of hypermethylation of host cell genes in cervical carcinogenesis and discusses potential clinical applications of methylation analysis in the management of high-risk HPV (hrHPV) -positive women. We argue that methylation assays can be used: 1. for primary triage of hrHPV-positive women to detect cervical cancer and advanced cervical intraepithelial neoplasia (CIN); 2. as secondary triage for women with minor cytological abnormalities to identify those with the highest risk of CIN3 or worse; 3. as exit test for women leaving the screening programme to identify cervical cancer and advanced CIN; and 4. to support management of CIN. Tweetable abstract: This paper discusses potential clinical applications of DNA methylation analysis in the management of women with a high-risk HPV infection.
|Number of pages||11|
|Journal||BJOG: An International Journal of Obstetrics & Gynaecology|
|Early online date||3 Jul 2020|
|Publication status||Published - Feb 2021|