The use of perfusion CT for the evaluation of therapy combining AZD2171 with gefitinib in cancer patients

Martijn R. Meijerink*, Hester van Cruijsen, Klaas Hoekman, Matthijs Kater, Cors Schaik, Jan Hein T.M. van Waesberghe, Giuseppe Giaccone, Radu A. Manoliu

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

Abstract

The purpose of this study was to determine the feasibility of dynamic contrast-enhanced perfusion CT (CTP) in evaluating the hemodynamic response of tumors in the chest and abdomen treated with a combination of AZD2171 and gefitinib. Thirteen patients were examined just before and every 4-6 weeks after starting therapy. Following intravenous injection of a contrast agent, dynamic image acquisition was obtained at the level of a selected tumor location. To calculate perfusion, the maximum-slope method was used. Pre-treatment average perfusion for extra-hepatic masses was 84 ml/min/100 g, for liver masses arterial perfusion was 25 ml/min/100 g, and a portal perfusion of 30 ml/min/100 g was found. After the administration of AZD2171 and gefitinib, in extra-hepatic masses an initial decrease in perfusion of 18% was followed by a plateau and in liver masses an initial decrease of 39% within the lesions and of 36% within a rim region surrounding the lesions was followed by a tendency to recovery of hepatic artery flow. In conclusion, CTP is feasible in showing changes of perfusion induced by anti-angiogenic therapy.

Original languageEnglish
Pages (from-to)1700-1713
Number of pages14
JournalEuropean Radiology
Volume17
Issue number7
DOIs
Publication statusPublished - 1 Jul 2007

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