The Vascular Impairment of Cognition Classification Consensus Study

Olivia A. Skrobot, Seth Love, Patrick G. Kehoe*, John O'Brien, Sandra Black, Christopher Chen, Charles DeCarli, Timo Erkinjuntti, Gary A. Ford, Rajesh N. Kalaria, Leonardo Pantoni, Florence Pasquier, Gustavo C. Roman, Anders Wallin, Perminder Sachdev, Perminder Sachdev, Ingmar Skoog, Yoav Ben-Shlomo, Anthony P. Passmore, VICCCS group

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review


Introduction Numerous diagnostic criteria have tried to tackle the variability in clinical manifestations and problematic diagnosis of vascular cognitive impairment (VCI) but none have been universally accepted. These criteria have not been readily comparable, impacting on clinical diagnosis rates and in turn prevalence estimates, research, and treatment. Methods The Vascular Impairment of Cognition Classification Consensus Study (VICCCS) involved participants (81% academic researchers) from 27 countries in an online Delphi consensus study. Participants reviewed previously proposed concepts to develop new guidelines. Results VICCCS had a mean of 122 (98–153) respondents across the study and a 67% threshold to represent consensus. VICCCS redefined VCI including classification of mild and major forms of VCI and subtypes. It proposes new standardized VCI-associated terminology and future research priorities to address gaps in current knowledge. Discussion VICCCS proposes a consensus-based updated conceptualization of VCI intended to facilitate standardization in research.

Original languageEnglish
Pages (from-to)624-633
Number of pages10
JournalAlzheimer's and Dementia
Issue number6
Publication statusPublished - 1 Jun 2017

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