The vascular response induced by transmyocardial laser revascularization is determined by the size of the channel scar: Results of CO2, holmium and excimer lasers

Menno Huikeshoven; Jeroen A M Beliën; Raymond Tukkie; Johan F Beek

doi:10.1002/lsm.20070

The vascular response induced by transmyocardial laser revascularization is determined by the size of the channel scar: Results of CO2, holmium and excimer lasers

Menno Huikeshoven, Jeroen A M Beliën, Raymond Tukkie, Johan F Beek

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

BACKGROUND AND OBJECTIVES: To investigate the angiogenic effect of CO2, Ho:YSGG, and XeCl excimer TMLR in a rat model with morphologic characteristics of chronic myocardial ischemia.

STUDY DESIGN/MATERIALS AND METHODS: Two channels (200-320 microm) were created per rat heart. After 14 days, vessel numbers and densities in and around laser scars were assessed.

RESULTS: Capillary densities in the laser scars were equal between the three lasers ( approximately 130 vessels/mm2) but much lower than in control areas ( approximately 2,100 vessels/mm2). Vessel densities excluding capillaries were significantly higher in Ho:YSGG and CO2 scars compared to excimer scars, while only Ho:YSGG scars contained significantly more large vessels (diameter > or = 20 microm) than control areas. Only rarely, extension of vascular growth into adjacent myocardium was observed in any of the three groups.

CONCLUSIONS: These results indicate that the angiogenic response following TMLR is limited to the channel scar and related to the scar size rather than the specific laser type.

Original language	English
Pages (from-to)	35-40
Number of pages	6
Journal	Lasers in Surgery and Medicine
Volume	35
Issue number	1
DOIs	https://doi.org/10.1002/lsm.20070
Publication status	Published - 2004

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@article{10155a21428c42d4901142d141e10b4d,

title = "The vascular response induced by transmyocardial laser revascularization is determined by the size of the channel scar: Results of CO2, holmium and excimer lasers",

abstract = "BACKGROUND AND OBJECTIVES: To investigate the angiogenic effect of CO2, Ho:YSGG, and XeCl excimer TMLR in a rat model with morphologic characteristics of chronic myocardial ischemia.STUDY DESIGN/MATERIALS AND METHODS: Two channels (200-320 microm) were created per rat heart. After 14 days, vessel numbers and densities in and around laser scars were assessed.RESULTS: Capillary densities in the laser scars were equal between the three lasers ( approximately 130 vessels/mm2) but much lower than in control areas ( approximately 2,100 vessels/mm2). Vessel densities excluding capillaries were significantly higher in Ho:YSGG and CO2 scars compared to excimer scars, while only Ho:YSGG scars contained significantly more large vessels (diameter > or = 20 microm) than control areas. Only rarely, extension of vascular growth into adjacent myocardium was observed in any of the three groups.CONCLUSIONS: These results indicate that the angiogenic response following TMLR is limited to the channel scar and related to the scar size rather than the specific laser type.",

keywords = "Animals, Carbon Dioxide, Cicatrix, Coronary Vessels, Holmium, Laser Therapy, Male, Myocardial Ischemia, Myocardial Revascularization, Neovascularization, Physiologic, Rats, Rats, Inbred SHR, Journal Article, Research Support, Non-U.S. Gov't",

author = "Menno Huikeshoven and Beli{\"e}n, {Jeroen A M} and Raymond Tukkie and Beek, {Johan F}",

year = "2004",

doi = "10.1002/lsm.20070",

language = "English",

volume = "35",

pages = "35--40",

journal = "Lasers in Surgery and Medicine",

issn = "0196-8092",

publisher = "Wiley-Liss Inc.",

number = "1",

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The vascular response induced by transmyocardial laser revascularization is determined by the size of the channel scar : Results of CO2, holmium and excimer lasers. / Huikeshoven, Menno; Beliën, Jeroen A M; Tukkie, Raymond et al.

In: Lasers in Surgery and Medicine, Vol. 35, No. 1, 2004, p. 35-40.

Research output: Contribution to journal › Article › Academic › peer-review

TY - JOUR

T1 - The vascular response induced by transmyocardial laser revascularization is determined by the size of the channel scar

T2 - Results of CO2, holmium and excimer lasers

AU - Huikeshoven, Menno

AU - Beliën, Jeroen A M

AU - Tukkie, Raymond

AU - Beek, Johan F

PY - 2004

Y1 - 2004

N2 - BACKGROUND AND OBJECTIVES: To investigate the angiogenic effect of CO2, Ho:YSGG, and XeCl excimer TMLR in a rat model with morphologic characteristics of chronic myocardial ischemia.STUDY DESIGN/MATERIALS AND METHODS: Two channels (200-320 microm) were created per rat heart. After 14 days, vessel numbers and densities in and around laser scars were assessed.RESULTS: Capillary densities in the laser scars were equal between the three lasers ( approximately 130 vessels/mm2) but much lower than in control areas ( approximately 2,100 vessels/mm2). Vessel densities excluding capillaries were significantly higher in Ho:YSGG and CO2 scars compared to excimer scars, while only Ho:YSGG scars contained significantly more large vessels (diameter > or = 20 microm) than control areas. Only rarely, extension of vascular growth into adjacent myocardium was observed in any of the three groups.CONCLUSIONS: These results indicate that the angiogenic response following TMLR is limited to the channel scar and related to the scar size rather than the specific laser type.

AB - BACKGROUND AND OBJECTIVES: To investigate the angiogenic effect of CO2, Ho:YSGG, and XeCl excimer TMLR in a rat model with morphologic characteristics of chronic myocardial ischemia.STUDY DESIGN/MATERIALS AND METHODS: Two channels (200-320 microm) were created per rat heart. After 14 days, vessel numbers and densities in and around laser scars were assessed.RESULTS: Capillary densities in the laser scars were equal between the three lasers ( approximately 130 vessels/mm2) but much lower than in control areas ( approximately 2,100 vessels/mm2). Vessel densities excluding capillaries were significantly higher in Ho:YSGG and CO2 scars compared to excimer scars, while only Ho:YSGG scars contained significantly more large vessels (diameter > or = 20 microm) than control areas. Only rarely, extension of vascular growth into adjacent myocardium was observed in any of the three groups.CONCLUSIONS: These results indicate that the angiogenic response following TMLR is limited to the channel scar and related to the scar size rather than the specific laser type.

KW - Animals

KW - Carbon Dioxide

KW - Cicatrix

KW - Coronary Vessels

KW - Holmium

KW - Laser Therapy

KW - Male

KW - Myocardial Ischemia

KW - Myocardial Revascularization

KW - Neovascularization, Physiologic

KW - Rats

KW - Rats, Inbred SHR

KW - Journal Article

KW - Research Support, Non-U.S. Gov't

U2 - 10.1002/lsm.20070

DO - 10.1002/lsm.20070

M3 - Article

C2 - 15278926

VL - 35

SP - 35

EP - 40

JO - Lasers in Surgery and Medicine

JF - Lasers in Surgery and Medicine

SN - 0196-8092

IS - 1

ER -