Abstract
When administered in high dosages, salicylate acts as a vitamin K-antagonist: it induces a decrease of the plasma concentration of the Gla-containing coagulation factors and an accumulation of microsomal substrates for vitamin K-dependent carboxylase in the liver and in the lung. In vitro the drugs inhibit the DTT-dependent reductases which mediate the reduction of vitamin K epoxide and vitamin K quinone. NADH-dependent reductase and vitamin K-dependent carboxylase are not inhibited.
Original language | English |
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Pages (from-to) | 727-736 |
Number of pages | 10 |
Journal | Thrombosis Research |
Volume | 42 |
Issue number | 6 |
DOIs | |
Publication status | Published - 15 Jun 1986 |