The vitamin k-antagonism of salicylate and warfarin

M. C. Roncaglioni; M. M W Ulrich; A. D. Muller; B. A M Soute; M. A G de Boer-van den Berg; C. Vermeer

doi:10.1016/0049-3848(86)90109-X

The vitamin k-antagonism of salicylate and warfarin

M. C. Roncaglioni, M. M W Ulrich, A. D. Muller, B. A M Soute, M. A G de Boer-van den Berg, C. Vermeer

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

When administered in high dosages, salicylate acts as a vitamin K-antagonist: it induces a decrease of the plasma concentration of the Gla-containing coagulation factors and an accumulation of microsomal substrates for vitamin K-dependent carboxylase in the liver and in the lung. In vitro the drugs inhibit the DTT-dependent reductases which mediate the reduction of vitamin K epoxide and vitamin K quinone. NADH-dependent reductase and vitamin K-dependent carboxylase are not inhibited.

Original language	English
Pages (from-to)	727-736
Number of pages	10
Journal	Thrombosis Research
Volume	42
Issue number	6
DOIs	https://doi.org/10.1016/0049-3848(86)90109-X
Publication status	Published - 15 Jun 1986

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title = "The vitamin k-antagonism of salicylate and warfarin",

abstract = "When administered in high dosages, salicylate acts as a vitamin K-antagonist: it induces a decrease of the plasma concentration of the Gla-containing coagulation factors and an accumulation of microsomal substrates for vitamin K-dependent carboxylase in the liver and in the lung. In vitro the drugs inhibit the DTT-dependent reductases which mediate the reduction of vitamin K epoxide and vitamin K quinone. NADH-dependent reductase and vitamin K-dependent carboxylase are not inhibited.",

keywords = "-carboxyglutamic acid, carboxylase, reductase salicylate, Vitamin K, warfarin",

author = "Roncaglioni, {M. C.} and Ulrich, {M. M W} and Muller, {A. D.} and Soute, {B. A M} and {de Boer-van den Berg}, {M. A G} and C. Vermeer",

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AU - Roncaglioni, M. C.

AU - Ulrich, M. M W

AU - Muller, A. D.

AU - Soute, B. A M

AU - de Boer-van den Berg, M. A G

AU - Vermeer, C.

PY - 1986/6/15

Y1 - 1986/6/15

N2 - When administered in high dosages, salicylate acts as a vitamin K-antagonist: it induces a decrease of the plasma concentration of the Gla-containing coagulation factors and an accumulation of microsomal substrates for vitamin K-dependent carboxylase in the liver and in the lung. In vitro the drugs inhibit the DTT-dependent reductases which mediate the reduction of vitamin K epoxide and vitamin K quinone. NADH-dependent reductase and vitamin K-dependent carboxylase are not inhibited.

AB - When administered in high dosages, salicylate acts as a vitamin K-antagonist: it induces a decrease of the plasma concentration of the Gla-containing coagulation factors and an accumulation of microsomal substrates for vitamin K-dependent carboxylase in the liver and in the lung. In vitro the drugs inhibit the DTT-dependent reductases which mediate the reduction of vitamin K epoxide and vitamin K quinone. NADH-dependent reductase and vitamin K-dependent carboxylase are not inhibited.

KW - -carboxyglutamic acid

KW - carboxylase

KW - reductase salicylate

KW - Vitamin K

KW - warfarin

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U2 - 10.1016/0049-3848(86)90109-X

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AN - SCOPUS:0022532810

VL - 42

SP - 727

EP - 736

JO - Thrombosis Research

JF - Thrombosis Research

SN - 0049-3848

IS - 6

ER -

The vitamin k-antagonism of salicylate and warfarin

Abstract

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