Thermal Skin Damage During Reirradiation and Hyperthermia Is Time-Temperature Dependent

Akke Bakker, M. Willemijn Kolff, Rebecca Holman, Caspar M. van Leeuwen, Linda Korshuize-van Straten, Rianne de Kroon-Oldenhof, Coen R. N. Rasch, Geertjan van Tienhoven, Hans Crezee

Research output: Contribution to journalArticleAcademicpeer-review

Abstract

Purpose To investigate the relationship of thermal skin damage (TSD) to time–temperature isoeffect levels for patients with breast cancer recurrence treated with reirradiation plus hyperthermia (reRT + HT), and to investigate whether the treatment history of previous treatments (scar tissue) is a risk factor for TSD. Methods and Materials In this observational study, temperature characteristics of hyperthermia sessions were analyzed in 262 patients with recurrent breast cancer treated in the AMC between 2010 and 2014 with reirradiation and weekly hyperthermia for 1 hour. Skin temperature was measured using a median of 42 (range, 29-82) measurement points per hyperthermia session. Results Sixty-eight patients (26%) developed 79 sites of TSD, after the first (n=26), second (n=17), third (n=27), and fourth (n=9) hyperthermia session. Seventy percent of TSD occurred on or near scar tissue. Scar tissue reached higher temperatures than other skin tissue (0.4°C, P<.001). A total of 102 measurement points corresponded to actual TSD sites in 35 of 79 sessions in which TSD developed. Thermal skin damage sites had much higher maximum temperatures than non-TSD sites (2.8°C, P<.001). Generalized linear mixed models showed that the probability of TSD is related to temperature and thermal dose values (P<.001) and that scar tissue is more at risk (odds ratio 0.4, P<.001). Limiting the maximum temperature of a measurement point to 43.7°C would mean that the probability of observing TSD was at most 5%. Conclusion Thermal skin damage during reRT + HT for recurrent breast cancer was related to higher local temperatures and time–temperature isoeffect levels. Scar tissue reached higher temperatures than other skin tissue, and TSD occurred at lower temperatures and thermal dose values in scar tissue compared with other skin tissue. Indeed, TSD developed often on and around scar tissue from previous surgical procedures.
Original languageEnglish
Pages (from-to)392-399
JournalInternational Journal of Radiation Oncology Biology Physics
Volume98
Issue number2
DOIs
Publication statusPublished - 2017
Externally publishedYes

Cite this

Bakker, A., Kolff, M. W., Holman, R., van Leeuwen, C. M., Korshuize-van Straten, L., de Kroon-Oldenhof, R., ... Crezee, H. (2017). Thermal Skin Damage During Reirradiation and Hyperthermia Is Time-Temperature Dependent. International Journal of Radiation Oncology Biology Physics, 98(2), 392-399. https://doi.org/10.1016/j.ijrobp.2017.02.009