Abstract

We aimed to investigate associations between regional cortical thickness and rate of decline over time in 4 cognitive domains in patients with subjective cognitive decline (SCD). We included 233 SCD patients with the total number of 654 neuropsychological assessments (median = 3, range = 2–8) and available baseline magnetic resonance imaging from the Amsterdam Dementia Cohort (125 males, age: 63 ± 9, Mini–Mental State Examination score: 28 ± 2). We assessed longitudinal cognitive functioning at baseline and follow-up in 4 cognitive domains (composite Z-scores): memory, attention, executive function, and language. Thickness (millimeter) was estimated using FreeSurfer for frontal, temporal, parietal, cingulate, and occipital cortices. We used linear mixed models to estimate effects of cortical thickness on cognitive performance (dependent variables). There were no associations between cortical thickness and baseline cognition, but a faster subsequent rate of memory loss was associated with thinner cortex of the frontal [β (SE) = 0.20 (0.07)], temporal [β (SE) = 0.18 (0.07)], and occipital [β (SE) = 0.22 (0.09)] cortices (all p < 0.05FDR). These findings illustrate that early cortical changes, particularly in the temporal cortex, herald incipient cognitive decline related to neurodegenerative diseases, most prominently Alzheimer's disease.

Original languageEnglish
Pages (from-to)238-244
Number of pages7
JournalNeurobiology of Aging
Volume61
DOIs
Publication statusPublished - 1 Jan 2018

Cite this

@article{625a3c2e24554983abbe82e258d30a4f,
title = "Thinner cortex in patients with subjective cognitive decline is associated with steeper decline of memory",
abstract = "We aimed to investigate associations between regional cortical thickness and rate of decline over time in 4 cognitive domains in patients with subjective cognitive decline (SCD). We included 233 SCD patients with the total number of 654 neuropsychological assessments (median = 3, range = 2–8) and available baseline magnetic resonance imaging from the Amsterdam Dementia Cohort (125 males, age: 63 ± 9, Mini–Mental State Examination score: 28 ± 2). We assessed longitudinal cognitive functioning at baseline and follow-up in 4 cognitive domains (composite Z-scores): memory, attention, executive function, and language. Thickness (millimeter) was estimated using FreeSurfer for frontal, temporal, parietal, cingulate, and occipital cortices. We used linear mixed models to estimate effects of cortical thickness on cognitive performance (dependent variables). There were no associations between cortical thickness and baseline cognition, but a faster subsequent rate of memory loss was associated with thinner cortex of the frontal [β (SE) = 0.20 (0.07)], temporal [β (SE) = 0.18 (0.07)], and occipital [β (SE) = 0.22 (0.09)] cortices (all p < 0.05FDR). These findings illustrate that early cortical changes, particularly in the temporal cortex, herald incipient cognitive decline related to neurodegenerative diseases, most prominently Alzheimer's disease.",
keywords = "Aged, Alzheimer Disease/etiology, Cerebral Cortex/diagnostic imaging, Cognition, Cognitive Dysfunction/complications, Cohort Studies, Female, Humans, Language, Magnetic Resonance Imaging, Male, Memory, Mental Status and Dementia Tests, Middle Aged",
author = "Verfaillie, {Sander C.J.} and Slot, {Rosalinde E.} and Tijms, {Betty M.} and Femke Bouwman and Benedictus, {Marije R.} and Overbeek, {Jozefien M.} and Teddy Koene and Hugo Vrenken and Philip Scheltens and Frederik Barkhof and {van der Flier}, {Wiesje M.}",
note = "Copyright {\circledC} 2017 Elsevier Inc. All rights reserved.",
year = "2018",
month = "1",
day = "1",
doi = "10.1016/j.neurobiolaging.2017.09.009",
language = "English",
volume = "61",
pages = "238--244",
journal = "Neurobiology of Aging",
issn = "0197-4580",
publisher = "Elsevier Inc.",

}

TY - JOUR

T1 - Thinner cortex in patients with subjective cognitive decline is associated with steeper decline of memory

AU - Verfaillie, Sander C.J.

AU - Slot, Rosalinde E.

AU - Tijms, Betty M.

AU - Bouwman, Femke

AU - Benedictus, Marije R.

AU - Overbeek, Jozefien M.

AU - Koene, Teddy

AU - Vrenken, Hugo

AU - Scheltens, Philip

AU - Barkhof, Frederik

AU - van der Flier, Wiesje M.

N1 - Copyright © 2017 Elsevier Inc. All rights reserved.

PY - 2018/1/1

Y1 - 2018/1/1

N2 - We aimed to investigate associations between regional cortical thickness and rate of decline over time in 4 cognitive domains in patients with subjective cognitive decline (SCD). We included 233 SCD patients with the total number of 654 neuropsychological assessments (median = 3, range = 2–8) and available baseline magnetic resonance imaging from the Amsterdam Dementia Cohort (125 males, age: 63 ± 9, Mini–Mental State Examination score: 28 ± 2). We assessed longitudinal cognitive functioning at baseline and follow-up in 4 cognitive domains (composite Z-scores): memory, attention, executive function, and language. Thickness (millimeter) was estimated using FreeSurfer for frontal, temporal, parietal, cingulate, and occipital cortices. We used linear mixed models to estimate effects of cortical thickness on cognitive performance (dependent variables). There were no associations between cortical thickness and baseline cognition, but a faster subsequent rate of memory loss was associated with thinner cortex of the frontal [β (SE) = 0.20 (0.07)], temporal [β (SE) = 0.18 (0.07)], and occipital [β (SE) = 0.22 (0.09)] cortices (all p < 0.05FDR). These findings illustrate that early cortical changes, particularly in the temporal cortex, herald incipient cognitive decline related to neurodegenerative diseases, most prominently Alzheimer's disease.

AB - We aimed to investigate associations between regional cortical thickness and rate of decline over time in 4 cognitive domains in patients with subjective cognitive decline (SCD). We included 233 SCD patients with the total number of 654 neuropsychological assessments (median = 3, range = 2–8) and available baseline magnetic resonance imaging from the Amsterdam Dementia Cohort (125 males, age: 63 ± 9, Mini–Mental State Examination score: 28 ± 2). We assessed longitudinal cognitive functioning at baseline and follow-up in 4 cognitive domains (composite Z-scores): memory, attention, executive function, and language. Thickness (millimeter) was estimated using FreeSurfer for frontal, temporal, parietal, cingulate, and occipital cortices. We used linear mixed models to estimate effects of cortical thickness on cognitive performance (dependent variables). There were no associations between cortical thickness and baseline cognition, but a faster subsequent rate of memory loss was associated with thinner cortex of the frontal [β (SE) = 0.20 (0.07)], temporal [β (SE) = 0.18 (0.07)], and occipital [β (SE) = 0.22 (0.09)] cortices (all p < 0.05FDR). These findings illustrate that early cortical changes, particularly in the temporal cortex, herald incipient cognitive decline related to neurodegenerative diseases, most prominently Alzheimer's disease.

KW - Aged

KW - Alzheimer Disease/etiology

KW - Cerebral Cortex/diagnostic imaging

KW - Cognition

KW - Cognitive Dysfunction/complications

KW - Cohort Studies

KW - Female

KW - Humans

KW - Language

KW - Magnetic Resonance Imaging

KW - Male

KW - Memory

KW - Mental Status and Dementia Tests

KW - Middle Aged

UR - http://www.scopus.com/inward/record.url?scp=85030778598&partnerID=8YFLogxK

U2 - 10.1016/j.neurobiolaging.2017.09.009

DO - 10.1016/j.neurobiolaging.2017.09.009

M3 - Article

VL - 61

SP - 238

EP - 244

JO - Neurobiology of Aging

JF - Neurobiology of Aging

SN - 0197-4580

ER -