Thinner temporal and parietal cortex is related to incident clinical progression to dementia in patients with subjective cognitive decline

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Abstract

INTRODUCTION: We aimed to investigate if thinner cortex of the Alzheimer's disease (AD)-signature region was related to clinical progression in patients with subjective cognitive decline (SCD).

METHODS: We included 302 SCD patients with clinical follow-up (≥1 year) and three-dimensional T1 magnetic resonance imaging. We estimated AD-signature cortical thickness, consisting of nine frontal, parietal, and temporal gyri and hippocampal volume. We used Cox proportional hazard models (hazard ratios and 95% confidence intervals) to evaluate cortical thickness in relation to clinical progression to mild cognitive impairment (MCI) or dementia.

RESULTS: After a follow-up of the mean (standard deviation) 3 (2) years, 49 patients (16%) showed clinical progression to MCI (n = 32), AD (n = 9), or non-AD dementia (n = 8). Hippocampal volumes, thinner cortex of the AD-signature (hazard ratio [95% confidence interval], 5 [2-17]) and various AD-signature subcomponents were associated with increased risk of clinical progression. Stratified analyses showed that thinner AD-signature cortex was specifically predictive for clinical progression to dementia but not to MCI.

DISCUSSION: In SCD patients, thinner regional cortex is associated with clinical progression to dementia.

Original languageEnglish
Pages (from-to)43-52
Number of pages10
JournalAlzheimer's & dementia (Amsterdam, Netherlands)
Volume5
DOIs
Publication statusPublished - 2016

Cite this

@article{41052e4890974d998b2cabbf90f9e93b,
title = "Thinner temporal and parietal cortex is related to incident clinical progression to dementia in patients with subjective cognitive decline",
abstract = "INTRODUCTION: We aimed to investigate if thinner cortex of the Alzheimer's disease (AD)-signature region was related to clinical progression in patients with subjective cognitive decline (SCD).METHODS: We included 302 SCD patients with clinical follow-up (≥1 year) and three-dimensional T1 magnetic resonance imaging. We estimated AD-signature cortical thickness, consisting of nine frontal, parietal, and temporal gyri and hippocampal volume. We used Cox proportional hazard models (hazard ratios and 95{\%} confidence intervals) to evaluate cortical thickness in relation to clinical progression to mild cognitive impairment (MCI) or dementia.RESULTS: After a follow-up of the mean (standard deviation) 3 (2) years, 49 patients (16{\%}) showed clinical progression to MCI (n = 32), AD (n = 9), or non-AD dementia (n = 8). Hippocampal volumes, thinner cortex of the AD-signature (hazard ratio [95{\%} confidence interval], 5 [2-17]) and various AD-signature subcomponents were associated with increased risk of clinical progression. Stratified analyses showed that thinner AD-signature cortex was specifically predictive for clinical progression to dementia but not to MCI.DISCUSSION: In SCD patients, thinner regional cortex is associated with clinical progression to dementia.",
author = "Verfaillie, {Sander C J} and Betty Tijms and Adriaan Versteeg and Benedictus, {Marije R} and Bouwman, {Femke H} and Philip Scheltens and Frederik Barkhof and Hugo Vrenken and {van der Flier}, {Wiesje M}",
year = "2016",
doi = "10.1016/j.dadm.2016.10.007",
language = "English",
volume = "5",
pages = "43--52",
journal = "Alzheimer's & dementia (Amsterdam, Netherlands)",

}

TY - JOUR

T1 - Thinner temporal and parietal cortex is related to incident clinical progression to dementia in patients with subjective cognitive decline

AU - Verfaillie, Sander C J

AU - Tijms, Betty

AU - Versteeg, Adriaan

AU - Benedictus, Marije R

AU - Bouwman, Femke H

AU - Scheltens, Philip

AU - Barkhof, Frederik

AU - Vrenken, Hugo

AU - van der Flier, Wiesje M

PY - 2016

Y1 - 2016

N2 - INTRODUCTION: We aimed to investigate if thinner cortex of the Alzheimer's disease (AD)-signature region was related to clinical progression in patients with subjective cognitive decline (SCD).METHODS: We included 302 SCD patients with clinical follow-up (≥1 year) and three-dimensional T1 magnetic resonance imaging. We estimated AD-signature cortical thickness, consisting of nine frontal, parietal, and temporal gyri and hippocampal volume. We used Cox proportional hazard models (hazard ratios and 95% confidence intervals) to evaluate cortical thickness in relation to clinical progression to mild cognitive impairment (MCI) or dementia.RESULTS: After a follow-up of the mean (standard deviation) 3 (2) years, 49 patients (16%) showed clinical progression to MCI (n = 32), AD (n = 9), or non-AD dementia (n = 8). Hippocampal volumes, thinner cortex of the AD-signature (hazard ratio [95% confidence interval], 5 [2-17]) and various AD-signature subcomponents were associated with increased risk of clinical progression. Stratified analyses showed that thinner AD-signature cortex was specifically predictive for clinical progression to dementia but not to MCI.DISCUSSION: In SCD patients, thinner regional cortex is associated with clinical progression to dementia.

AB - INTRODUCTION: We aimed to investigate if thinner cortex of the Alzheimer's disease (AD)-signature region was related to clinical progression in patients with subjective cognitive decline (SCD).METHODS: We included 302 SCD patients with clinical follow-up (≥1 year) and three-dimensional T1 magnetic resonance imaging. We estimated AD-signature cortical thickness, consisting of nine frontal, parietal, and temporal gyri and hippocampal volume. We used Cox proportional hazard models (hazard ratios and 95% confidence intervals) to evaluate cortical thickness in relation to clinical progression to mild cognitive impairment (MCI) or dementia.RESULTS: After a follow-up of the mean (standard deviation) 3 (2) years, 49 patients (16%) showed clinical progression to MCI (n = 32), AD (n = 9), or non-AD dementia (n = 8). Hippocampal volumes, thinner cortex of the AD-signature (hazard ratio [95% confidence interval], 5 [2-17]) and various AD-signature subcomponents were associated with increased risk of clinical progression. Stratified analyses showed that thinner AD-signature cortex was specifically predictive for clinical progression to dementia but not to MCI.DISCUSSION: In SCD patients, thinner regional cortex is associated with clinical progression to dementia.

U2 - 10.1016/j.dadm.2016.10.007

DO - 10.1016/j.dadm.2016.10.007

M3 - Article

VL - 5

SP - 43

EP - 52

JO - Alzheimer's & dementia (Amsterdam, Netherlands)

JF - Alzheimer's & dementia (Amsterdam, Netherlands)

ER -