Thiopurines in Inflammatory Bowel Disease: new findings and perspectives

Nanne K H de Boer, Laurent Peyrin-Biroulet, Bindia Jharap, Jeremy D Sanderson, Berrie Meijer, Imke Atreya, Murray L Barclay, Jean-Frederic Colombel, Anthony Lopez, Laurent Beaugerie, Anthony M Marinaki, Adriaan A van Bodegraven, Markus F Neurath

Research output: Contribution to journalArticleAcademicpeer-review

Abstract

Thiopurines, available as azathioprine, mercaptopurine and thioguanine, are immunomodulating agents primarily used to maintain corticosteroid-free remission in patients with inflammatory bowel disease. To provide a state-of-the-art overview of thiopurine treatment in inflammatory bowel disease, this clinical review critically summarizes the available literature, as assessed by several experts in the field of thiopurine treatment and research in inflammatory bowel disease.

Original languageEnglish
Pages (from-to)610-620
Number of pages11
JournalJournal of Crohn's & colitis
Volume12
Issue number5
Early online date25 Dec 2017
DOIs
Publication statusPublished - 27 Apr 2018

Cite this

de Boer, N. K. H., Peyrin-Biroulet, L., Jharap, B., Sanderson, J. D., Meijer, B., Atreya, I., ... Neurath, M. F. (2018). Thiopurines in Inflammatory Bowel Disease: new findings and perspectives. Journal of Crohn's & colitis, 12(5), 610-620. https://doi.org/10.1093/ecco-jcc/jjx181