Three-dimensional myocardial strains at end-systole and during diastole in the left ventricle of normal humans

Joost P.A. Kuijer*, J. Tim Marcus, Marco J.W. Götte, Albert C. Van Rossum, Robert M. Heethaar

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

Abstract

This paper presents the three-dimensional strains in the normal human left ventricle (LV) at end-systole and during diastole. Magnetic resonance tissue tagging was used to measure strain in the left-ventricular heart wall in 10 healthy volunteers aged between 28 and 61 years. The three-dimensional motion was calculated from the displacement of marker points in short- and long-axis cine images, with a time resolution of 30 msec. Homogeneous strain analysis of small tetrahedrons was used to calculate deformation in 18 regions of the LV over a time span of 300msec starting at end systole. End-systolic radial strain was largest near the heart base, and circumferential and longitudinal strains were largest near the apex. During diastole, the circumferential-longitudinal shear strain (associated with LV torsion) was found to recover earlier than the axial strains. Assessment of three-dimensional diastolic strain is possible with MR tagging. Comparison of patient strain against normal strain may permit early detection of regional diastolic dysfunction.

Original languageEnglish
Pages (from-to)341-351
Number of pages11
JournalJournal of Cardiovascular Magnetic Resonance
Volume4
Issue number3
DOIs
Publication statusPublished - 2002

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