Three-dimensional optical coherence tomography imaging for glaucoma associated with boston keratoprosthesis type i and II

Ziad Khoueir, Firas Jassim, Boy Braaf, Linda Yi-Chieh Poon, Edem Tsikata, James Chodosh, Claes H. Dohlman, Benjamin J. Vakoc, Brett E. Bouma, Johannes F. de Boer, Teresa C. Chen

Research output: Contribution to journalArticleAcademicpeer-review

Abstract

Precis:Three-dimensional (3D) spectral domain optical coherence tomography (OCT) volume scans of the optic nerve head (ONH) and the peripapillary area are useful in the management of glaucoma in patients with a type I or II Boston Keratoprosthesis (KPro).Purpose:The purpose of this study was to report the use of spectral domain OCT in the management of glaucoma in patients with a type I or II Boston KPro.Materials and Methods:This study is an observational case series. Four consecutive patients with KPro implants were referred for glaucoma evaluation. A comprehensive eye examination was performed which included disc photography, visual field testing, and high-density spectral domain OCT volume scans of the ONH and the peripapillary area. 2D and 3D parameters were calculated using custom-designed segmentation algorithms developed for glaucoma management.Results:Spectral domain OCT parameters provided useful information in the diagnosis and management of 4 KPro patients. OCT parameters which can be used in KPro patients included 2D retinal nerve fiber layer (RNFL) thickness, 3D peripapillary RNFL volume, 3D peripapillary retinal thickness and volume, 3D cup volume, and 3D neuroretinal rim thickness and volume. In 3 of 4 cases where the traditional 2D RNFL thickness scan was limited by artifacts, 3D spectral domain OCT volume scans provided useful quantitative objective measurements of the ONH and peripapillary region. Therefore, 3D parameters derived from high-density volume scans as well as radial scans of the ONH can be used to overcome the limitations and artifacts associated with 2D RNFL thickness scans.Conclusions:Spectral domain OCT volume scans offer the possibility to enhance the evaluation of KPro patients with glaucoma by using both 2D and 3D diagnostic parameters that are easily obtained in a clinic setting.
Original languageEnglish
Pages (from-to)718-726
Number of pages9
JournalJournal of Glaucoma
Volume28
Issue number8
DOIs
Publication statusPublished - 1 Aug 2019

Cite this

Khoueir, Ziad ; Jassim, Firas ; Braaf, Boy ; Poon, Linda Yi-Chieh ; Tsikata, Edem ; Chodosh, James ; Dohlman, Claes H. ; Vakoc, Benjamin J. ; Bouma, Brett E. ; de Boer, Johannes F. ; Chen, Teresa C. / Three-dimensional optical coherence tomography imaging for glaucoma associated with boston keratoprosthesis type i and II. In: Journal of Glaucoma. 2019 ; Vol. 28, No. 8. pp. 718-726.
@article{56f5747f804a4bce8795158c3be81f6c,
title = "Three-dimensional optical coherence tomography imaging for glaucoma associated with boston keratoprosthesis type i and II",
abstract = "Precis:Three-dimensional (3D) spectral domain optical coherence tomography (OCT) volume scans of the optic nerve head (ONH) and the peripapillary area are useful in the management of glaucoma in patients with a type I or II Boston Keratoprosthesis (KPro).Purpose:The purpose of this study was to report the use of spectral domain OCT in the management of glaucoma in patients with a type I or II Boston KPro.Materials and Methods:This study is an observational case series. Four consecutive patients with KPro implants were referred for glaucoma evaluation. A comprehensive eye examination was performed which included disc photography, visual field testing, and high-density spectral domain OCT volume scans of the ONH and the peripapillary area. 2D and 3D parameters were calculated using custom-designed segmentation algorithms developed for glaucoma management.Results:Spectral domain OCT parameters provided useful information in the diagnosis and management of 4 KPro patients. OCT parameters which can be used in KPro patients included 2D retinal nerve fiber layer (RNFL) thickness, 3D peripapillary RNFL volume, 3D peripapillary retinal thickness and volume, 3D cup volume, and 3D neuroretinal rim thickness and volume. In 3 of 4 cases where the traditional 2D RNFL thickness scan was limited by artifacts, 3D spectral domain OCT volume scans provided useful quantitative objective measurements of the ONH and peripapillary region. Therefore, 3D parameters derived from high-density volume scans as well as radial scans of the ONH can be used to overcome the limitations and artifacts associated with 2D RNFL thickness scans.Conclusions:Spectral domain OCT volume scans offer the possibility to enhance the evaluation of KPro patients with glaucoma by using both 2D and 3D diagnostic parameters that are easily obtained in a clinic setting.",
keywords = "diagnosis, glaucoma, keratoprosthesis, retinal nerve fiber layer, spectral domain optical coherence tomography",
author = "Ziad Khoueir and Firas Jassim and Boy Braaf and Poon, {Linda Yi-Chieh} and Edem Tsikata and James Chodosh and Dohlman, {Claes H.} and Vakoc, {Benjamin J.} and Bouma, {Brett E.} and {de Boer}, {Johannes F.} and Chen, {Teresa C.}",
year = "2019",
month = "8",
day = "1",
doi = "10.1097/IJG.0000000000001280",
language = "English",
volume = "28",
pages = "718--726",
journal = "Journal of Glaucoma",
issn = "1057-0829",
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Khoueir, Z, Jassim, F, Braaf, B, Poon, LY-C, Tsikata, E, Chodosh, J, Dohlman, CH, Vakoc, BJ, Bouma, BE, de Boer, JF & Chen, TC 2019, 'Three-dimensional optical coherence tomography imaging for glaucoma associated with boston keratoprosthesis type i and II' Journal of Glaucoma, vol. 28, no. 8, pp. 718-726. https://doi.org/10.1097/IJG.0000000000001280

Three-dimensional optical coherence tomography imaging for glaucoma associated with boston keratoprosthesis type i and II. / Khoueir, Ziad; Jassim, Firas; Braaf, Boy; Poon, Linda Yi-Chieh; Tsikata, Edem; Chodosh, James; Dohlman, Claes H.; Vakoc, Benjamin J.; Bouma, Brett E.; de Boer, Johannes F.; Chen, Teresa C.

In: Journal of Glaucoma, Vol. 28, No. 8, 01.08.2019, p. 718-726.

Research output: Contribution to journalArticleAcademicpeer-review

TY - JOUR

T1 - Three-dimensional optical coherence tomography imaging for glaucoma associated with boston keratoprosthesis type i and II

AU - Khoueir, Ziad

AU - Jassim, Firas

AU - Braaf, Boy

AU - Poon, Linda Yi-Chieh

AU - Tsikata, Edem

AU - Chodosh, James

AU - Dohlman, Claes H.

AU - Vakoc, Benjamin J.

AU - Bouma, Brett E.

AU - de Boer, Johannes F.

AU - Chen, Teresa C.

PY - 2019/8/1

Y1 - 2019/8/1

N2 - Precis:Three-dimensional (3D) spectral domain optical coherence tomography (OCT) volume scans of the optic nerve head (ONH) and the peripapillary area are useful in the management of glaucoma in patients with a type I or II Boston Keratoprosthesis (KPro).Purpose:The purpose of this study was to report the use of spectral domain OCT in the management of glaucoma in patients with a type I or II Boston KPro.Materials and Methods:This study is an observational case series. Four consecutive patients with KPro implants were referred for glaucoma evaluation. A comprehensive eye examination was performed which included disc photography, visual field testing, and high-density spectral domain OCT volume scans of the ONH and the peripapillary area. 2D and 3D parameters were calculated using custom-designed segmentation algorithms developed for glaucoma management.Results:Spectral domain OCT parameters provided useful information in the diagnosis and management of 4 KPro patients. OCT parameters which can be used in KPro patients included 2D retinal nerve fiber layer (RNFL) thickness, 3D peripapillary RNFL volume, 3D peripapillary retinal thickness and volume, 3D cup volume, and 3D neuroretinal rim thickness and volume. In 3 of 4 cases where the traditional 2D RNFL thickness scan was limited by artifacts, 3D spectral domain OCT volume scans provided useful quantitative objective measurements of the ONH and peripapillary region. Therefore, 3D parameters derived from high-density volume scans as well as radial scans of the ONH can be used to overcome the limitations and artifacts associated with 2D RNFL thickness scans.Conclusions:Spectral domain OCT volume scans offer the possibility to enhance the evaluation of KPro patients with glaucoma by using both 2D and 3D diagnostic parameters that are easily obtained in a clinic setting.

AB - Precis:Three-dimensional (3D) spectral domain optical coherence tomography (OCT) volume scans of the optic nerve head (ONH) and the peripapillary area are useful in the management of glaucoma in patients with a type I or II Boston Keratoprosthesis (KPro).Purpose:The purpose of this study was to report the use of spectral domain OCT in the management of glaucoma in patients with a type I or II Boston KPro.Materials and Methods:This study is an observational case series. Four consecutive patients with KPro implants were referred for glaucoma evaluation. A comprehensive eye examination was performed which included disc photography, visual field testing, and high-density spectral domain OCT volume scans of the ONH and the peripapillary area. 2D and 3D parameters were calculated using custom-designed segmentation algorithms developed for glaucoma management.Results:Spectral domain OCT parameters provided useful information in the diagnosis and management of 4 KPro patients. OCT parameters which can be used in KPro patients included 2D retinal nerve fiber layer (RNFL) thickness, 3D peripapillary RNFL volume, 3D peripapillary retinal thickness and volume, 3D cup volume, and 3D neuroretinal rim thickness and volume. In 3 of 4 cases where the traditional 2D RNFL thickness scan was limited by artifacts, 3D spectral domain OCT volume scans provided useful quantitative objective measurements of the ONH and peripapillary region. Therefore, 3D parameters derived from high-density volume scans as well as radial scans of the ONH can be used to overcome the limitations and artifacts associated with 2D RNFL thickness scans.Conclusions:Spectral domain OCT volume scans offer the possibility to enhance the evaluation of KPro patients with glaucoma by using both 2D and 3D diagnostic parameters that are easily obtained in a clinic setting.

KW - diagnosis

KW - glaucoma

KW - keratoprosthesis

KW - retinal nerve fiber layer

KW - spectral domain optical coherence tomography

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UR - https://www.ncbi.nlm.nih.gov/pubmed/31169563

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DO - 10.1097/IJG.0000000000001280

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EP - 726

JO - Journal of Glaucoma

JF - Journal of Glaucoma

SN - 1057-0829

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