TY - JOUR
T1 - Three-dimensional organization of dendrites and local axon collaterals of shell and core medium-sized spiny projection neurons of the rat nucleus accumbens
AU - van Dongen, Yvette
AU - Mailly, Philippe
AU - Thierry, Anne-Marie
AU - Groenewegen, Henk
AU - Deniau, Jean-Michel
PY - 2008
Y1 - 2008
N2 - Medium-sized spiny projection neurons (MSN)
in the head of the primate caudate nucleus are thought to
have preferred dendritic orientations that tend to parallel
the orientations of the striosomes. Moreover, recurrent
axon collaterals of MSN in the rat dorsal striatum have
been categorized into two types, i.e., restricted and
widespread. The nucleus accumbens (Acb) has a highly
complex compartmental organization, and the spatial
organization of dendritic and axonal arbors of MSN has not
yet been systematically studied. In this study, using singlecell
juxtacellular labeling with neurobiotin as well as
anterograde neuroanatomical tracing with biotinylated
dextran amine, we investigated the three-dimensional (3D)
organization of dendrites and axons of MSN of the rat Acb
in relation to subregional (shell-core) and compartmental
(patch-matrix) boundaries. Our results show that dendritic
arbors of MSN in both the Acb shell and core subregions
are preferentially oriented, i.e., they are flattened in at least
one of the 3D-planes. The preferred orientations are
influenced by shell-core and patch-matrix boundaries,
suggesting parallel and independent processing of information.
Dendritic orientations of MSN of the Acb core are
more heterogeneous than those of the shell and the dorsal
striatum, suggesting a more complex distribution of striatal
inputs within the core. Although dendrites respect the shellcore
and patch-matrix boundaries, recurrent axon collaterals
may cross these boundaries. Finally, different degrees
of overlap between dendritic and axonal arborizations of
individual MSN were identified, suggesting various possibilities
of lateral inhibitory interactions within and
between, functionally distinct territories of the Acb.
AB - Medium-sized spiny projection neurons (MSN)
in the head of the primate caudate nucleus are thought to
have preferred dendritic orientations that tend to parallel
the orientations of the striosomes. Moreover, recurrent
axon collaterals of MSN in the rat dorsal striatum have
been categorized into two types, i.e., restricted and
widespread. The nucleus accumbens (Acb) has a highly
complex compartmental organization, and the spatial
organization of dendritic and axonal arbors of MSN has not
yet been systematically studied. In this study, using singlecell
juxtacellular labeling with neurobiotin as well as
anterograde neuroanatomical tracing with biotinylated
dextran amine, we investigated the three-dimensional (3D)
organization of dendrites and axons of MSN of the rat Acb
in relation to subregional (shell-core) and compartmental
(patch-matrix) boundaries. Our results show that dendritic
arbors of MSN in both the Acb shell and core subregions
are preferentially oriented, i.e., they are flattened in at least
one of the 3D-planes. The preferred orientations are
influenced by shell-core and patch-matrix boundaries,
suggesting parallel and independent processing of information.
Dendritic orientations of MSN of the Acb core are
more heterogeneous than those of the shell and the dorsal
striatum, suggesting a more complex distribution of striatal
inputs within the core. Although dendrites respect the shellcore
and patch-matrix boundaries, recurrent axon collaterals
may cross these boundaries. Finally, different degrees
of overlap between dendritic and axonal arborizations of
individual MSN were identified, suggesting various possibilities
of lateral inhibitory interactions within and
between, functionally distinct territories of the Acb.
M3 - Article
VL - 213
JO - Brain Structure and Function
JF - Brain Structure and Function
SN - 1863-2653
ER -