Time-restricted feeding improves adaptation to chronically alternating light-dark cycles

Maaike Schilperoort, Rosa van den Berg, Martijn E. T. Dollé, Conny T. M. van Oostrom, Karina Wagner, Lauren L. Tambyrajah, Paul Wackers, Tom Deboer, Gerben Hulsegge, Karin I. Proper, Harry van Steeg, Till Roenneberg, Nienke R. Biermasz, Patrick C. N. Rensen, Sander Kooijman, Linda W. M. van Kerkhof

Research output: Contribution to journalArticleAcademicpeer-review

Abstract

Disturbance of the circadian clock has been associated with increased risk of cardio-metabolic disorders. Previous studies showed that optimal timing of food intake can improve metabolic health. We hypothesized that time-restricted feeding could be a strategy to minimize long term adverse metabolic health effects of shift work and jetlag. In this study, we exposed female FVB mice to weekly alternating light-dark cycles (i.e. 12 h shifts) combined with ad libitum feeding, dark phase feeding or feeding at a fixed clock time, in the original dark phase. In contrast to our expectations, long-term disturbance of the circadian clock had only modest effects on metabolic parameters. Mice fed at a fixed time showed a delayed adaptation compared to ad libitum fed animals, in terms of the similarity in 24 h rhythm of core body temperature, in weeks when food was only available in the light phase. This was accompanied by increased plasma triglyceride levels and decreased energy expenditure, indicating a less favorable metabolic state. On the other hand, dark phase feeding accelerated adaptation of core body temperature and activity rhythms, however, did not improve the metabolic state of animals compared to ad libitum feeding. Taken together, restricting food intake to the active dark phase enhanced adaptation to shifts in the light-dark schedule, without significantly affecting metabolic parameters.
Original languageEnglish
Article number7874
JournalScientific Reports
Volume9
Issue number1
DOIs
Publication statusPublished - 1 Dec 2019
Externally publishedYes

Cite this

Schilperoort, M., van den Berg, R., Dollé, M. E. T., van Oostrom, C. T. M., Wagner, K., Tambyrajah, L. L., ... van Kerkhof, L. W. M. (2019). Time-restricted feeding improves adaptation to chronically alternating light-dark cycles. Scientific Reports, 9(1), [7874]. https://doi.org/10.1038/s41598-019-44398-7
Schilperoort, Maaike ; van den Berg, Rosa ; Dollé, Martijn E. T. ; van Oostrom, Conny T. M. ; Wagner, Karina ; Tambyrajah, Lauren L. ; Wackers, Paul ; Deboer, Tom ; Hulsegge, Gerben ; Proper, Karin I. ; van Steeg, Harry ; Roenneberg, Till ; Biermasz, Nienke R. ; Rensen, Patrick C. N. ; Kooijman, Sander ; van Kerkhof, Linda W. M. / Time-restricted feeding improves adaptation to chronically alternating light-dark cycles. In: Scientific Reports. 2019 ; Vol. 9, No. 1.
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title = "Time-restricted feeding improves adaptation to chronically alternating light-dark cycles",
abstract = "Disturbance of the circadian clock has been associated with increased risk of cardio-metabolic disorders. Previous studies showed that optimal timing of food intake can improve metabolic health. We hypothesized that time-restricted feeding could be a strategy to minimize long term adverse metabolic health effects of shift work and jetlag. In this study, we exposed female FVB mice to weekly alternating light-dark cycles (i.e. 12 h shifts) combined with ad libitum feeding, dark phase feeding or feeding at a fixed clock time, in the original dark phase. In contrast to our expectations, long-term disturbance of the circadian clock had only modest effects on metabolic parameters. Mice fed at a fixed time showed a delayed adaptation compared to ad libitum fed animals, in terms of the similarity in 24 h rhythm of core body temperature, in weeks when food was only available in the light phase. This was accompanied by increased plasma triglyceride levels and decreased energy expenditure, indicating a less favorable metabolic state. On the other hand, dark phase feeding accelerated adaptation of core body temperature and activity rhythms, however, did not improve the metabolic state of animals compared to ad libitum feeding. Taken together, restricting food intake to the active dark phase enhanced adaptation to shifts in the light-dark schedule, without significantly affecting metabolic parameters.",
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Schilperoort, M, van den Berg, R, Dollé, MET, van Oostrom, CTM, Wagner, K, Tambyrajah, LL, Wackers, P, Deboer, T, Hulsegge, G, Proper, KI, van Steeg, H, Roenneberg, T, Biermasz, NR, Rensen, PCN, Kooijman, S & van Kerkhof, LWM 2019, 'Time-restricted feeding improves adaptation to chronically alternating light-dark cycles' Scientific Reports, vol. 9, no. 1, 7874. https://doi.org/10.1038/s41598-019-44398-7

Time-restricted feeding improves adaptation to chronically alternating light-dark cycles. / Schilperoort, Maaike; van den Berg, Rosa; Dollé, Martijn E. T.; van Oostrom, Conny T. M.; Wagner, Karina; Tambyrajah, Lauren L.; Wackers, Paul; Deboer, Tom; Hulsegge, Gerben; Proper, Karin I.; van Steeg, Harry; Roenneberg, Till; Biermasz, Nienke R.; Rensen, Patrick C. N.; Kooijman, Sander; van Kerkhof, Linda W. M.

In: Scientific Reports, Vol. 9, No. 1, 7874, 01.12.2019.

Research output: Contribution to journalArticleAcademicpeer-review

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T1 - Time-restricted feeding improves adaptation to chronically alternating light-dark cycles

AU - Schilperoort, Maaike

AU - van den Berg, Rosa

AU - Dollé, Martijn E. T.

AU - van Oostrom, Conny T. M.

AU - Wagner, Karina

AU - Tambyrajah, Lauren L.

AU - Wackers, Paul

AU - Deboer, Tom

AU - Hulsegge, Gerben

AU - Proper, Karin I.

AU - van Steeg, Harry

AU - Roenneberg, Till

AU - Biermasz, Nienke R.

AU - Rensen, Patrick C. N.

AU - Kooijman, Sander

AU - van Kerkhof, Linda W. M.

PY - 2019/12/1

Y1 - 2019/12/1

N2 - Disturbance of the circadian clock has been associated with increased risk of cardio-metabolic disorders. Previous studies showed that optimal timing of food intake can improve metabolic health. We hypothesized that time-restricted feeding could be a strategy to minimize long term adverse metabolic health effects of shift work and jetlag. In this study, we exposed female FVB mice to weekly alternating light-dark cycles (i.e. 12 h shifts) combined with ad libitum feeding, dark phase feeding or feeding at a fixed clock time, in the original dark phase. In contrast to our expectations, long-term disturbance of the circadian clock had only modest effects on metabolic parameters. Mice fed at a fixed time showed a delayed adaptation compared to ad libitum fed animals, in terms of the similarity in 24 h rhythm of core body temperature, in weeks when food was only available in the light phase. This was accompanied by increased plasma triglyceride levels and decreased energy expenditure, indicating a less favorable metabolic state. On the other hand, dark phase feeding accelerated adaptation of core body temperature and activity rhythms, however, did not improve the metabolic state of animals compared to ad libitum feeding. Taken together, restricting food intake to the active dark phase enhanced adaptation to shifts in the light-dark schedule, without significantly affecting metabolic parameters.

AB - Disturbance of the circadian clock has been associated with increased risk of cardio-metabolic disorders. Previous studies showed that optimal timing of food intake can improve metabolic health. We hypothesized that time-restricted feeding could be a strategy to minimize long term adverse metabolic health effects of shift work and jetlag. In this study, we exposed female FVB mice to weekly alternating light-dark cycles (i.e. 12 h shifts) combined with ad libitum feeding, dark phase feeding or feeding at a fixed clock time, in the original dark phase. In contrast to our expectations, long-term disturbance of the circadian clock had only modest effects on metabolic parameters. Mice fed at a fixed time showed a delayed adaptation compared to ad libitum fed animals, in terms of the similarity in 24 h rhythm of core body temperature, in weeks when food was only available in the light phase. This was accompanied by increased plasma triglyceride levels and decreased energy expenditure, indicating a less favorable metabolic state. On the other hand, dark phase feeding accelerated adaptation of core body temperature and activity rhythms, however, did not improve the metabolic state of animals compared to ad libitum feeding. Taken together, restricting food intake to the active dark phase enhanced adaptation to shifts in the light-dark schedule, without significantly affecting metabolic parameters.

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Schilperoort M, van den Berg R, Dollé MET, van Oostrom CTM, Wagner K, Tambyrajah LL et al. Time-restricted feeding improves adaptation to chronically alternating light-dark cycles. Scientific Reports. 2019 Dec 1;9(1). 7874. https://doi.org/10.1038/s41598-019-44398-7