Toward the Early Detection of Cancer by Decoding the Epigenetic and Environmental Fingerprints of Cell-Free DNA

Research output: Contribution to journalReview articleAcademicpeer-review

Abstract

Widespread adaptation of liquid biopsy for the early detection of cancer has yet to reach clinical utility. Circulating tumor DNA is commonly detected though the presence of genetic alterations, but only a minor fraction of tumor-derived cell-free DNA (cfDNA) fragments exhibit mutations. The cellular processes occurring in cancer development mark the chromatin. These epigenetic marks are reflected by modifications in the cfDNA methylation, fragment size, and structure. In this review, we describe how going beyond DNA sequence information alone, by analyzing cfDNA epigenetic and immune signatures, boosts the potential of liquid biopsy for the early detection of cancer.

Original languageEnglish
Pages (from-to)350-368
Number of pages19
JournalCancer Cell
Volume36
Issue number4
DOIs
Publication statusPublished - 14 Oct 2019

Cite this

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title = "Toward the Early Detection of Cancer by Decoding the Epigenetic and Environmental Fingerprints of Cell-Free DNA",
abstract = "Widespread adaptation of liquid biopsy for the early detection of cancer has yet to reach clinical utility. Circulating tumor DNA is commonly detected though the presence of genetic alterations, but only a minor fraction of tumor-derived cell-free DNA (cfDNA) fragments exhibit mutations. The cellular processes occurring in cancer development mark the chromatin. These epigenetic marks are reflected by modifications in the cfDNA methylation, fragment size, and structure. In this review, we describe how going beyond DNA sequence information alone, by analyzing cfDNA epigenetic and immune signatures, boosts the potential of liquid biopsy for the early detection of cancer.",
keywords = "cancer, cell-free DNA, chromatin, circulating tumor DNA, epigenetic, exosome, fragmentation, liquid biopsy, methylation, mutation, vesicle",
author = "{Van Der Pol}, Ymke and Florent Mouliere",
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language = "English",
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journal = "Cancer Cell",
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Toward the Early Detection of Cancer by Decoding the Epigenetic and Environmental Fingerprints of Cell-Free DNA. / Van Der Pol, Ymke; Mouliere, Florent.

In: Cancer Cell, Vol. 36, No. 4, 14.10.2019, p. 350-368.

Research output: Contribution to journalReview articleAcademicpeer-review

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