Transient increase in interleukin-8 and pulmonary microvascular permeability following aortic surgery

P G Raijmakers, A B Groeneveld, J A Rauwerda, A J Schneider, G J Teule, C E Hack, L G Thijs

Research output: Contribution to journalArticleAcademicpeer-review

Abstract

Aortic surgery results in ischemia/reperfusion of the lower body. This may liberate inflammatory mediators that activate neutrophils, and may result in lung microvascular changes with increased permeability and respiratory failure. We studied circulating inflammatory mediators and the pulmonary leak index (PLI) of 67Ga, a measure of transvascular transferrin transport and permeability, in patients scheduled for elective aortic and peripheral vascular surgery, before and after surgery. Aortic surgery patients in Groups 1 (n = 10) and 2 (n = 7) were studied before and at a median of 2.5 and 21.0 h after surgery, respectively. A control Group 3 (n = 6) was studied before and at a median of 2.9 h after peripheral vascular surgery. The PLI (median) increased from a median of 9.1 (range, 6.6 to 14.7) before to a median of 23.4 (range, 18.7 to 86.4) x 10(-3)/min after surgery in Group 1 but not in the other groups (p < 0.001). The postoperative increase in circulating neutrophils and elastase-alpha 1-antitrypsin, a marker of neutrophil activation, was similar among the groups. Plasma levels of activated complement 3a and tumor necrosis factor (TNF-alpha) did not change in any of the groups. In contrast, plasma levels of interleukin-8 (IL-8) increased in Group 1 from < 3 (range, < 3 to 37) before to 324 (range, 36 to 868) pg/ml after surgery, but did not change in the other groups (p < 0.005). The decrease in plasma levels of angiotensin converting enzyme (ACE) was greater in Group 1 than in the other groups (p < 0.05).(ABSTRACT TRUNCATED AT 250 WORDS)

Original languageEnglish
Pages (from-to)698-705
Number of pages8
JournalAmerican Journal of Respiratory and Critical Care Medicine
Volume151
Issue number3 Pt 1
DOIs
Publication statusPublished - Mar 1995

Cite this

@article{85c6d8a950194774896b4fadd910d43a,
title = "Transient increase in interleukin-8 and pulmonary microvascular permeability following aortic surgery",
abstract = "Aortic surgery results in ischemia/reperfusion of the lower body. This may liberate inflammatory mediators that activate neutrophils, and may result in lung microvascular changes with increased permeability and respiratory failure. We studied circulating inflammatory mediators and the pulmonary leak index (PLI) of 67Ga, a measure of transvascular transferrin transport and permeability, in patients scheduled for elective aortic and peripheral vascular surgery, before and after surgery. Aortic surgery patients in Groups 1 (n = 10) and 2 (n = 7) were studied before and at a median of 2.5 and 21.0 h after surgery, respectively. A control Group 3 (n = 6) was studied before and at a median of 2.9 h after peripheral vascular surgery. The PLI (median) increased from a median of 9.1 (range, 6.6 to 14.7) before to a median of 23.4 (range, 18.7 to 86.4) x 10(-3)/min after surgery in Group 1 but not in the other groups (p < 0.001). The postoperative increase in circulating neutrophils and elastase-alpha 1-antitrypsin, a marker of neutrophil activation, was similar among the groups. Plasma levels of activated complement 3a and tumor necrosis factor (TNF-alpha) did not change in any of the groups. In contrast, plasma levels of interleukin-8 (IL-8) increased in Group 1 from < 3 (range, < 3 to 37) before to 324 (range, 36 to 868) pg/ml after surgery, but did not change in the other groups (p < 0.005). The decrease in plasma levels of angiotensin converting enzyme (ACE) was greater in Group 1 than in the other groups (p < 0.05).(ABSTRACT TRUNCATED AT 250 WORDS)",
keywords = "Aged, Aortic Diseases/physiopathology, Capillary Permeability/physiology, Ischemia-reperfusion injury, lung injury, Pulmonary Edema/etiology, Female, Gallium Radioisotopes, Humans, Inflammation Mediators/metabolism, Interleukin-8/blood, Lung/blood supply, Male, Endothelial barrier function, Neutrophil Activation/physiology, Peptidyl-Dipeptidase A/metabolism, Peripheral Vascular Diseases/physiopathology, Postoperative Complications/etiology, Radionuclide Imaging, Reperfusion Injury/etiology, Respiratory Distress Syndrome, Adult/etiology, Sodium Pertechnetate Tc 99m, Femoral Artery/pathology, endothelial barrier, Tumor Necrosis Factor-alpha, Complement C3a, aortic aneurysm repair surgery, vascular surgery",
author = "Raijmakers, {P G} and Groeneveld, {A B} and Rauwerda, {J A} and Schneider, {A J} and Teule, {G J} and Hack, {C E} and Thijs, {L G}",
year = "1995",
month = "3",
doi = "10.1164/ajrccm.151.3.7881659",
language = "English",
volume = "151",
pages = "698--705",
journal = "American Journal of Respiratory and Critical Care Medicine",
issn = "1073-449X",
publisher = "American Thoracic Society",
number = "3 Pt 1",

}

Transient increase in interleukin-8 and pulmonary microvascular permeability following aortic surgery. / Raijmakers, P G; Groeneveld, A B; Rauwerda, J A; Schneider, A J; Teule, G J; Hack, C E; Thijs, L G.

In: American Journal of Respiratory and Critical Care Medicine, Vol. 151, No. 3 Pt 1, 03.1995, p. 698-705.

Research output: Contribution to journalArticleAcademicpeer-review

TY - JOUR

T1 - Transient increase in interleukin-8 and pulmonary microvascular permeability following aortic surgery

AU - Raijmakers, P G

AU - Groeneveld, A B

AU - Rauwerda, J A

AU - Schneider, A J

AU - Teule, G J

AU - Hack, C E

AU - Thijs, L G

PY - 1995/3

Y1 - 1995/3

N2 - Aortic surgery results in ischemia/reperfusion of the lower body. This may liberate inflammatory mediators that activate neutrophils, and may result in lung microvascular changes with increased permeability and respiratory failure. We studied circulating inflammatory mediators and the pulmonary leak index (PLI) of 67Ga, a measure of transvascular transferrin transport and permeability, in patients scheduled for elective aortic and peripheral vascular surgery, before and after surgery. Aortic surgery patients in Groups 1 (n = 10) and 2 (n = 7) were studied before and at a median of 2.5 and 21.0 h after surgery, respectively. A control Group 3 (n = 6) was studied before and at a median of 2.9 h after peripheral vascular surgery. The PLI (median) increased from a median of 9.1 (range, 6.6 to 14.7) before to a median of 23.4 (range, 18.7 to 86.4) x 10(-3)/min after surgery in Group 1 but not in the other groups (p < 0.001). The postoperative increase in circulating neutrophils and elastase-alpha 1-antitrypsin, a marker of neutrophil activation, was similar among the groups. Plasma levels of activated complement 3a and tumor necrosis factor (TNF-alpha) did not change in any of the groups. In contrast, plasma levels of interleukin-8 (IL-8) increased in Group 1 from < 3 (range, < 3 to 37) before to 324 (range, 36 to 868) pg/ml after surgery, but did not change in the other groups (p < 0.005). The decrease in plasma levels of angiotensin converting enzyme (ACE) was greater in Group 1 than in the other groups (p < 0.05).(ABSTRACT TRUNCATED AT 250 WORDS)

AB - Aortic surgery results in ischemia/reperfusion of the lower body. This may liberate inflammatory mediators that activate neutrophils, and may result in lung microvascular changes with increased permeability and respiratory failure. We studied circulating inflammatory mediators and the pulmonary leak index (PLI) of 67Ga, a measure of transvascular transferrin transport and permeability, in patients scheduled for elective aortic and peripheral vascular surgery, before and after surgery. Aortic surgery patients in Groups 1 (n = 10) and 2 (n = 7) were studied before and at a median of 2.5 and 21.0 h after surgery, respectively. A control Group 3 (n = 6) was studied before and at a median of 2.9 h after peripheral vascular surgery. The PLI (median) increased from a median of 9.1 (range, 6.6 to 14.7) before to a median of 23.4 (range, 18.7 to 86.4) x 10(-3)/min after surgery in Group 1 but not in the other groups (p < 0.001). The postoperative increase in circulating neutrophils and elastase-alpha 1-antitrypsin, a marker of neutrophil activation, was similar among the groups. Plasma levels of activated complement 3a and tumor necrosis factor (TNF-alpha) did not change in any of the groups. In contrast, plasma levels of interleukin-8 (IL-8) increased in Group 1 from < 3 (range, < 3 to 37) before to 324 (range, 36 to 868) pg/ml after surgery, but did not change in the other groups (p < 0.005). The decrease in plasma levels of angiotensin converting enzyme (ACE) was greater in Group 1 than in the other groups (p < 0.05).(ABSTRACT TRUNCATED AT 250 WORDS)

KW - Aged

KW - Aortic Diseases/physiopathology

KW - Capillary Permeability/physiology

KW - Ischemia-reperfusion injury

KW - lung injury

KW - Pulmonary Edema/etiology

KW - Female

KW - Gallium Radioisotopes

KW - Humans

KW - Inflammation Mediators/metabolism

KW - Interleukin-8/blood

KW - Lung/blood supply

KW - Male

KW - Endothelial barrier function

KW - Neutrophil Activation/physiology

KW - Peptidyl-Dipeptidase A/metabolism

KW - Peripheral Vascular Diseases/physiopathology

KW - Postoperative Complications/etiology

KW - Radionuclide Imaging

KW - Reperfusion Injury/etiology

KW - Respiratory Distress Syndrome, Adult/etiology

KW - Sodium Pertechnetate Tc 99m

KW - Femoral Artery/pathology

KW - endothelial barrier

KW - Tumor Necrosis Factor-alpha

KW - Complement C3a

KW - aortic aneurysm repair surgery

KW - vascular surgery

U2 - 10.1164/ajrccm.151.3.7881659

DO - 10.1164/ajrccm.151.3.7881659

M3 - Article

VL - 151

SP - 698

EP - 705

JO - American Journal of Respiratory and Critical Care Medicine

JF - American Journal of Respiratory and Critical Care Medicine

SN - 1073-449X

IS - 3 Pt 1

ER -