Translocations (X;10)(p22;q24) and (1;10)(q21;q11) in a follicular adenoma of the thyroid without apparent involvement of the RET protooncogene

Shama Van Zelderen-Bhola*, Robbert Vink, Jan Smit, Hans Wessels, Hans Morreau

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review


We report here the cytogenetic analysis of a follicular adenoma of the thyroid which revealed an abnormal clone with a t(X;10)(p22;q24) and a t(1;10)(q21;q11) together with normal cells. Fluorescence in situ hybridization (FISH) with YACs 273E3 and 344H4, which are located on 10q11.2 and are specific for the RET protooncogene, showed no abnormalities. It would therefore appear that this gene is not involved in this particular tumor, as has been reported in a number of papillary thyroid carcinomas. Several chromosomal aberrations have been suggested as being specific for follicular thyroid adenoma. However, until now, only a few such cases have been reported which involve structural abnormalities of chromosomes 10q11.2 and 10q24. We believe this to be the first report of a follicular thyroid adenoma with a t(X;10) and a t(1;10). Copyright (C) 1999 Elsevier Science Inc.

Original languageEnglish
Pages (from-to)178-180
Number of pages3
JournalCancer Genetics and Cytogenetics
Issue number2
Publication statusPublished - 15 Jul 1999

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