Transplantability of Human Head and Neck Squamous Cell Carcinomas in Athymic Nude Mice

Boudewijn J.M. Braakhuis*, Dick A.W. Laarman, Jos J.P. Nauta, Marijke Van Walsum, Guus A.M.S. Van Dongen, Gordon B. Snow

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

Abstract

Tumor material from 91 patients with squamous cell carcinoma of the head and neck was transplanted subcutaneously in athymic nude mice. In the first (man to mouse) passage, the calculated mean probability of tumor take in a single mouse was 11%. The probability of growth in the first passage was significantly better for moderately and poorly differentiated tumors than for well-differentiated tumors. Also, the implantation of lymph node material resulted in a significantly better tumor take rate than material taken from a primary tumor. Transplantability was not dependent on the following characteristics: localization, T or N stage of the tumor, or the sex of the patients. Once growth was established, all variables studied had no influence on the probability of growth in the subsequent mouse passages. A relationship between tumor growth in nude mice and patient prognosis could not be found. When transplanting head and neck squamous cell carcinoma in nude mice, it has to be recognized that some tumor characteristics will influence the success of tumor growth.

Original languageEnglish
Pages (from-to)1076-1078
Number of pages3
JournalArchives of Otolaryngology--Head and Neck Surgery
Volume115
Issue number9
DOIs
Publication statusPublished - 1 Jan 1989

Cite this