Treatment of depression in Parkinson's disease: A meta-analysis

T. Klaassen, F. R.J. Verhey*, G. H.J.M. Sneijders, N. Rozendaal, H. C.W. De Vet, H. M. Van Praag

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

Abstract

Despite a 40% prevalence of depression in idiopathic Parkinson's disease (PD), an extensive literature search found only 12 controlled studies of treatment efficacy. A meta-analysis of these was performed in pursuit of guidelines for pharmacological treatment. Articles were scored on a scale from 0 to 100 on a specially adapted list of methodological criteria. Only 4 articles scored more than 50 points, and these generally did not use depression rating scales. Thus, there are virtually no empirical data on the treatment of depression in PD. Further studies are urgently needed, both for the sake of patient care and to gain a better understanding of the pathophysiological mechanisms underlying depression in PD and the interrelation between depression and cognitive decline.

Original languageEnglish
Pages (from-to)281-286
Number of pages6
JournalJournal of Neuropsychiatry and Clinical Neurosciences
Volume7
Issue number3
DOIs
Publication statusPublished - 1 Jan 1995

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