Treatment of isolated systolic hypertension is most effective in older patients with high-risk profile

Luigi Ferrucci, Curt D. Furberg, Brenda W.J.H. Penninx, Mauro DiBari, Jeff D. Williamson, Jack M. Guralnik, John G. Chen, William B. Applegate, Marco Pahor

Research output: Contribution to journalArticleAcademicpeer-review

Abstract

Background - Although present guidelines suggest that treatment of hypertension is more effective in patients with multiple risk factors and higher risk of cardiovascular events, this hypothesis was never verified in older patients with systolic hypertension. Methods and Results - Using data from the Systolic Hypertension in the Elderly Program, we calculated the global cardiovascular risk score according to the American Heart Association Multiple Risk Factor Assessment Equation in 4,189 participants free of cardiovascular disease (CVD) and in 264 participants with CVD at baseline. In the placebo group, rates of cardiovascular events over 4.5 years were progressively higher according to higher quartiles of CVD risk. The protection conferred by treatment was similar across quartiles of risk. However, the numbers needed to treat (NNTs) to prevent one cardiovascular event were progressively smaller according to higher cardiovascular risk quartiles. In participants with baseline CVD, the NNTs to prevent one cardiovascular event were similar to those estimated for CVD-free participants in the highest-risk quartile. Conclusions - Treatment of systolic hypertension is most effective in older patients who, because of additional risk factors or prevalent CVD, are at higher risk of developing a cardiovascular event. These patients are prime candidates for antihypertensive treatment.

Original languageEnglish
Pages (from-to)1923-1926
Number of pages4
JournalCirculation
Volume104
Issue number16
DOIs
Publication statusPublished - 16 Oct 2001
Externally publishedYes

Cite this

Ferrucci, L., Furberg, C. D., Penninx, B. W. J. H., DiBari, M., Williamson, J. D., Guralnik, J. M., ... Pahor, M. (2001). Treatment of isolated systolic hypertension is most effective in older patients with high-risk profile. Circulation, 104(16), 1923-1926. https://doi.org/10.1161/hc4101.097520
Ferrucci, Luigi ; Furberg, Curt D. ; Penninx, Brenda W.J.H. ; DiBari, Mauro ; Williamson, Jeff D. ; Guralnik, Jack M. ; Chen, John G. ; Applegate, William B. ; Pahor, Marco. / Treatment of isolated systolic hypertension is most effective in older patients with high-risk profile. In: Circulation. 2001 ; Vol. 104, No. 16. pp. 1923-1926.
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abstract = "Background - Although present guidelines suggest that treatment of hypertension is more effective in patients with multiple risk factors and higher risk of cardiovascular events, this hypothesis was never verified in older patients with systolic hypertension. Methods and Results - Using data from the Systolic Hypertension in the Elderly Program, we calculated the global cardiovascular risk score according to the American Heart Association Multiple Risk Factor Assessment Equation in 4,189 participants free of cardiovascular disease (CVD) and in 264 participants with CVD at baseline. In the placebo group, rates of cardiovascular events over 4.5 years were progressively higher according to higher quartiles of CVD risk. The protection conferred by treatment was similar across quartiles of risk. However, the numbers needed to treat (NNTs) to prevent one cardiovascular event were progressively smaller according to higher cardiovascular risk quartiles. In participants with baseline CVD, the NNTs to prevent one cardiovascular event were similar to those estimated for CVD-free participants in the highest-risk quartile. Conclusions - Treatment of systolic hypertension is most effective in older patients who, because of additional risk factors or prevalent CVD, are at higher risk of developing a cardiovascular event. These patients are prime candidates for antihypertensive treatment.",
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year = "2001",
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Ferrucci, L, Furberg, CD, Penninx, BWJH, DiBari, M, Williamson, JD, Guralnik, JM, Chen, JG, Applegate, WB & Pahor, M 2001, 'Treatment of isolated systolic hypertension is most effective in older patients with high-risk profile' Circulation, vol. 104, no. 16, pp. 1923-1926. https://doi.org/10.1161/hc4101.097520

Treatment of isolated systolic hypertension is most effective in older patients with high-risk profile. / Ferrucci, Luigi; Furberg, Curt D.; Penninx, Brenda W.J.H.; DiBari, Mauro; Williamson, Jeff D.; Guralnik, Jack M.; Chen, John G.; Applegate, William B.; Pahor, Marco.

In: Circulation, Vol. 104, No. 16, 16.10.2001, p. 1923-1926.

Research output: Contribution to journalArticleAcademicpeer-review

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T1 - Treatment of isolated systolic hypertension is most effective in older patients with high-risk profile

AU - Ferrucci, Luigi

AU - Furberg, Curt D.

AU - Penninx, Brenda W.J.H.

AU - DiBari, Mauro

AU - Williamson, Jeff D.

AU - Guralnik, Jack M.

AU - Chen, John G.

AU - Applegate, William B.

AU - Pahor, Marco

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N2 - Background - Although present guidelines suggest that treatment of hypertension is more effective in patients with multiple risk factors and higher risk of cardiovascular events, this hypothesis was never verified in older patients with systolic hypertension. Methods and Results - Using data from the Systolic Hypertension in the Elderly Program, we calculated the global cardiovascular risk score according to the American Heart Association Multiple Risk Factor Assessment Equation in 4,189 participants free of cardiovascular disease (CVD) and in 264 participants with CVD at baseline. In the placebo group, rates of cardiovascular events over 4.5 years were progressively higher according to higher quartiles of CVD risk. The protection conferred by treatment was similar across quartiles of risk. However, the numbers needed to treat (NNTs) to prevent one cardiovascular event were progressively smaller according to higher cardiovascular risk quartiles. In participants with baseline CVD, the NNTs to prevent one cardiovascular event were similar to those estimated for CVD-free participants in the highest-risk quartile. Conclusions - Treatment of systolic hypertension is most effective in older patients who, because of additional risk factors or prevalent CVD, are at higher risk of developing a cardiovascular event. These patients are prime candidates for antihypertensive treatment.

AB - Background - Although present guidelines suggest that treatment of hypertension is more effective in patients with multiple risk factors and higher risk of cardiovascular events, this hypothesis was never verified in older patients with systolic hypertension. Methods and Results - Using data from the Systolic Hypertension in the Elderly Program, we calculated the global cardiovascular risk score according to the American Heart Association Multiple Risk Factor Assessment Equation in 4,189 participants free of cardiovascular disease (CVD) and in 264 participants with CVD at baseline. In the placebo group, rates of cardiovascular events over 4.5 years were progressively higher according to higher quartiles of CVD risk. The protection conferred by treatment was similar across quartiles of risk. However, the numbers needed to treat (NNTs) to prevent one cardiovascular event were progressively smaller according to higher cardiovascular risk quartiles. In participants with baseline CVD, the NNTs to prevent one cardiovascular event were similar to those estimated for CVD-free participants in the highest-risk quartile. Conclusions - Treatment of systolic hypertension is most effective in older patients who, because of additional risk factors or prevalent CVD, are at higher risk of developing a cardiovascular event. These patients are prime candidates for antihypertensive treatment.

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