Abstract
- The treatment of patients with locally advanced non-small cell lung cancer (stage III) has changed significantly in the past few years. - Patients with a non-resectable stage IIIA/B tumour are given combined treatment consisting of chemotherapy and radiotherapy. These can be administered sequentially or concurrently. - It has been shown recently that concurrent chemoradiotherapy gives a survival advantage in comparison with sequential chemoradiotherapy. - Cisplatin and etoposide are usually the drugs of choice for chemotherapy in patients with stage III cancer. - A biologically effective dose of radiotherapy equivalent to 60-66 Gy, over a maximum of 6.5 weeks, should be given. - Surgery is possible for a selected group of patients, provided a complete objective mediastinal response has been achieved after chemoradiotherapy and a complete resection appears to be technically feasible. It is recommended to apply this treatment in a research setting. - High-dose concurrent chemoradiotherapy is advised as the standard treatment for stage III non-small cell lung cancer in patients in good physical condition.
Translated title of the contribution | Treatment of patients with stage III non-small cell lung cancer: Concurrent high-dose chemotherapy and radiotherapy |
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Original language | Dutch |
Pages (from-to) | 2714-2717 |
Number of pages | 4 |
Journal | Nederlands Tijdschrift voor Geneeskunde |
Volume | 152 |
Issue number | 50 |
Publication status | Published - 13 Dec 2008 |