Tricyclische antidepressiva en plasmaspiegels bij depressie: een praktische leidraad

Translated title of the contribution: Tricyclic antidepressant plasma levels in depression: a practical guide

R Vis, J J M Hassink, C H Vinkers

Research output: Contribution to journalReview articleAcademicpeer-review


BACKGROUND: Plasma levels can be used to monitor the clinical efficacy of tricyclic antidepressants (TCAs). In practice, the interpretation of plasma levels can be problematical, for several reasons: varying time-intervals between ingestion and blood sampling, the number of times per day a particular antidepressant is administered, the presence of active metabolites and the use of slow-release substances.

AIM: To present realistic recommendations regarding the interpretation of plasma levels of TCA in clinical practice.

METHOD: We studied the relevant literature.

CONCLUSION: On the basis of the literature we make the following recommendations:

Original languageDutch
Pages (from-to)695-705
Number of pages11
JournalTijdschrift voor Psychiatrie
Issue number9
Publication statusPublished - 2013
Externally publishedYes

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