BACKGROUND: Plasma levels can be used to monitor the clinical efficacy of tricyclic antidepressants (TCAs). In practice, the interpretation of plasma levels can be problematical, for several reasons: varying time-intervals between ingestion and blood sampling, the number of times per day a particular antidepressant is administered, the presence of active metabolites and the use of slow-release substances.
AIM: To present realistic recommendations regarding the interpretation of plasma levels of TCA in clinical practice.
METHOD: We studied the relevant literature.
CONCLUSION: On the basis of the literature we make the following recommendations:
|Translated title of the contribution||Tricyclic antidepressant plasma levels in depression: a practical guide|
|Number of pages||11|
|Journal||Tijdschrift voor Psychiatrie|
|Publication status||Published - 2013|