TY - JOUR
T1 - Two way communication between neutrophils and dendritic cells
AU - Ludwig, Irene S
AU - Geijtenbeek, Teunis B H
AU - van Kooyk, Yvette
PY - 2006/8
Y1 - 2006/8
N2 - Neutrophils are instrumental in innate immunity by mediating immediate removal of pathogens. Recent findings demonstrate that they are able to communicate with dendritic cells, which form a link between innate and adaptive immunity by stimulating long-term memory T cell responses. This communication occurs through the cell-surface receptors Mac-1 and carcinoembryonic antigen-related cellular adhesion molecule on neutrophils, which interact with C-type lectins such as dendritic cell-specific ICAM-3 grabbing non-integrin (DC-SIGN). Clearly, dendritic cells can prolong the lifespan of neutrophils, whereas neutrophils could direct dendritic cell-mediated T cell responses.
AB - Neutrophils are instrumental in innate immunity by mediating immediate removal of pathogens. Recent findings demonstrate that they are able to communicate with dendritic cells, which form a link between innate and adaptive immunity by stimulating long-term memory T cell responses. This communication occurs through the cell-surface receptors Mac-1 and carcinoembryonic antigen-related cellular adhesion molecule on neutrophils, which interact with C-type lectins such as dendritic cell-specific ICAM-3 grabbing non-integrin (DC-SIGN). Clearly, dendritic cells can prolong the lifespan of neutrophils, whereas neutrophils could direct dendritic cell-mediated T cell responses.
KW - Animals
KW - Cell Adhesion Molecules/immunology
KW - Cell Communication/immunology
KW - Dendritic Cells/immunology
KW - Humans
KW - Immunity, Active
KW - Immunity, Innate
KW - Inflammation/immunology
KW - Lectins, C-Type/immunology
KW - Liver/immunology
KW - Neutrophil Infiltration
KW - Neutrophils/immunology
KW - Receptors, Cell Surface/immunology
KW - Th1 Cells/immunology
KW - Th2 Cells/immunology
U2 - 10.1016/j.coph.2006.03.009
DO - 10.1016/j.coph.2006.03.009
M3 - Review article
C2 - 16750420
VL - 6
SP - 408
EP - 413
JO - Current opinion in pharmacology
JF - Current opinion in pharmacology
SN - 1471-4892
IS - 4
ER -