TYK2 Protein-Coding Variants Protect against Rheumatoid Arthritis and Autoimmunity, with No Evidence of Major Pleiotropic Effects on Non-Autoimmune Complex Traits

D. Diogo; L. Bastarache; K.P. Liao; R.R. Graham; R.S. Fulton; J.D. Greenberg; S. Eyre; J. Bowes; J. Cui; A. van der Lee; D.A. Pappas; J.M. Kremer; A. Barton; M.J.H. Coenen; B. Franke; L.A. Kiemeney; X. Mariette; C. Richard-Miceli; H. Canhao; J.E. Fonseca; N. de Vries; P.P. Tak; J.B.A. Crusius; M.T. Nurmohamed; F. Kurreeman; T.R. Mikuls; Y. Okada; E.A. Stahl; D.E. Larson; T.L. Deluca; M. O'Laughlin; C.C. Fronick; L.L. Fulton; R. Kosoy; M. Ransom; T.R. Bhangale; W. Ortmann; A. Cagan; V. Gainer; E.W. Karlson; I. Kohane; S.N. Murphy; J. Martin; A. Zhernakova; L. Klareskog; L. Padyukov; J. Worthington; E.R. Mardis; M.F. Seldin; P.K. Gregersen; T. Behrens; S. Raychaudhuri; J.C. Denny; R.M. Plenge

doi:10.1371/journal.pone.0122271

TYK2 Protein-Coding Variants Protect against Rheumatoid Arthritis and Autoimmunity, with No Evidence of Major Pleiotropic Effects on Non-Autoimmune Complex Traits

D. Diogo, L. Bastarache, K.P. Liao, R.R. Graham, R.S. Fulton, J.D. Greenberg, S. Eyre, J. Bowes, J. Cui, A. van der Lee, D.A. Pappas, J.M. Kremer, A. Barton, M.J.H. Coenen, B. Franke, L.A. Kiemeney, X. Mariette, C. Richard-Miceli, H. Canhao, J.E. FonsecaN. de Vries, P.P. Tak, J.B.A. Crusius, M.T. Nurmohamed, F. Kurreeman, T.R. Mikuls, Y. Okada, E.A. Stahl, D.E. Larson, T.L. Deluca, M. O'Laughlin, C.C. Fronick, L.L. Fulton, R. Kosoy, M. Ransom, T.R. Bhangale, W. Ortmann, A. Cagan, V. Gainer, E.W. Karlson, I. Kohane, S.N. Murphy, J. Martin, A. Zhernakova, L. Klareskog, L. Padyukov, J. Worthington, E.R. Mardis, M.F. Seldin, P.K. Gregersen, T. Behrens, S. Raychaudhuri, J.C. Denny, R.M. Plenge

Research output: Contribution to journal › Article › Academic › peer-review

Original language	Undefined/Unknown
Article number	e0122271
Journal	PLoS ONE
Volume	10
Issue number	4
DOIs	https://doi.org/10.1371/journal.pone.0122271
Publication status	Published - 2015

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Diogo, D., Bastarache, L., Liao, K. P., Graham, R. R., Fulton, R. S., Greenberg, J. D., Eyre, S., Bowes, J., Cui, J., van der Lee, A., Pappas, D. A., Kremer, J. M., Barton, A., Coenen, M. J. H., Franke, B., Kiemeney, L. A., Mariette, X., Richard-Miceli, C., Canhao, H., ... Plenge, R. M. (2015). TYK2 Protein-Coding Variants Protect against Rheumatoid Arthritis and Autoimmunity, with No Evidence of Major Pleiotropic Effects on Non-Autoimmune Complex Traits. PLoS ONE, 10(4), [e0122271]. https://doi.org/10.1371/journal.pone.0122271

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title = "TYK2 Protein-Coding Variants Protect against Rheumatoid Arthritis and Autoimmunity, with No Evidence of Major Pleiotropic Effects on Non-Autoimmune Complex Traits",

author = "D. Diogo and L. Bastarache and K.P. Liao and R.R. Graham and R.S. Fulton and J.D. Greenberg and S. Eyre and J. Bowes and J. Cui and {van der Lee}, A. and D.A. Pappas and J.M. Kremer and A. Barton and M.J.H. Coenen and B. Franke and L.A. Kiemeney and X. Mariette and C. Richard-Miceli and H. Canhao and J.E. Fonseca and {de Vries}, N. and P.P. Tak and J.B.A. Crusius and M.T. Nurmohamed and F. Kurreeman and T.R. Mikuls and Y. Okada and E.A. Stahl and D.E. Larson and T.L. Deluca and M. O'Laughlin and C.C. Fronick and L.L. Fulton and R. Kosoy and M. Ransom and T.R. Bhangale and W. Ortmann and A. Cagan and V. Gainer and E.W. Karlson and I. Kohane and S.N. Murphy and J. Martin and A. Zhernakova and L. Klareskog and L. Padyukov and J. Worthington and E.R. Mardis and M.F. Seldin and P.K. Gregersen and T. Behrens and S. Raychaudhuri and J.C. Denny and R.M. Plenge",

year = "2015",

doi = "10.1371/journal.pone.0122271",

language = "Undefined/Unknown",

volume = "10",

journal = "PLoS ONE",

issn = "1932-6203",

publisher = "Public Library of Science",

number = "4",

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Diogo, D, Bastarache, L, Liao, KP, Graham, RR, Fulton, RS, Greenberg, JD, Eyre, S, Bowes, J, Cui, J, van der Lee, A, Pappas, DA, Kremer, JM, Barton, A, Coenen, MJH, Franke, B, Kiemeney, LA, Mariette, X, Richard-Miceli, C, Canhao, H, Fonseca, JE, de Vries, N, Tak, PP, Crusius, JBA, Nurmohamed, MT, Kurreeman, F, Mikuls, TR, Okada, Y, Stahl, EA, Larson, DE, Deluca, TL, O'Laughlin, M, Fronick, CC, Fulton, LL, Kosoy, R, Ransom, M, Bhangale, TR, Ortmann, W, Cagan, A, Gainer, V, Karlson, EW, Kohane, I, Murphy, SN, Martin, J, Zhernakova, A, Klareskog, L, Padyukov, L, Worthington, J, Mardis, ER, Seldin, MF, Gregersen, PK, Behrens, T, Raychaudhuri, S, Denny, JC & Plenge, RM 2015, 'TYK2 Protein-Coding Variants Protect against Rheumatoid Arthritis and Autoimmunity, with No Evidence of Major Pleiotropic Effects on Non-Autoimmune Complex Traits', PLoS ONE, vol. 10, no. 4, e0122271. https://doi.org/10.1371/journal.pone.0122271

TY - JOUR

T1 - TYK2 Protein-Coding Variants Protect against Rheumatoid Arthritis and Autoimmunity, with No Evidence of Major Pleiotropic Effects on Non-Autoimmune Complex Traits

AU - Diogo, D.

AU - Bastarache, L.

AU - Liao, K.P.

AU - Graham, R.R.

AU - Fulton, R.S.

AU - Greenberg, J.D.

AU - Eyre, S.

AU - Bowes, J.

AU - Cui, J.

AU - van der Lee, A.

AU - Pappas, D.A.

AU - Kremer, J.M.

AU - Barton, A.

AU - Coenen, M.J.H.

AU - Franke, B.

AU - Kiemeney, L.A.

AU - Mariette, X.

AU - Richard-Miceli, C.

AU - Canhao, H.

AU - Fonseca, J.E.

AU - de Vries, N.

AU - Tak, P.P.

AU - Crusius, J.B.A.

AU - Nurmohamed, M.T.

AU - Kurreeman, F.

AU - Mikuls, T.R.

AU - Okada, Y.

AU - Stahl, E.A.

AU - Larson, D.E.

AU - Deluca, T.L.

AU - O'Laughlin, M.

AU - Fronick, C.C.

AU - Fulton, L.L.

AU - Kosoy, R.

AU - Ransom, M.

AU - Bhangale, T.R.

AU - Ortmann, W.

AU - Cagan, A.

AU - Gainer, V.

AU - Karlson, E.W.

AU - Kohane, I.

AU - Murphy, S.N.

AU - Martin, J.

AU - Zhernakova, A.

AU - Klareskog, L.

AU - Padyukov, L.

AU - Worthington, J.

AU - Mardis, E.R.

AU - Seldin, M.F.

AU - Gregersen, P.K.

AU - Behrens, T.

AU - Raychaudhuri, S.

AU - Denny, J.C.

AU - Plenge, R.M.

PY - 2015

Y1 - 2015

U2 - 10.1371/journal.pone.0122271

DO - 10.1371/journal.pone.0122271

M3 - Article

C2 - 25849893

VL - 10

JO - PLoS ONE

JF - PLoS ONE

SN - 1932-6203

IS - 4

M1 - e0122271

ER -