Abstract

Lymph nodes draining the primary tumor are essential for the initiation of an effective anti-tumor T-cell immune response. However, cancer-derived immune suppressive factors render the tumor-draining lymph nodes (TDLN) immune compromised, enabling tumors to invade and metastasize. Unraveling the different mechanisms underlying this immune escape will inform therapeutic intervention strategies to halt tumor spread in early clinical stages. Here, we review our findings from translational studies in melanoma, breast, and cervical cancer and discuss clinical opportunities for local immune modulation of TDLN in each of these indications.
Original languageEnglish
JournalCancer Immunology, Immunotherapy
DOIs
Publication statusPublished - 2019

Cite this

@article{a9a75e519b644e2cbb4863e47b35d686,
title = "Unlocking the therapeutic potential of primary tumor-draining lymph nodes",
abstract = "Lymph nodes draining the primary tumor are essential for the initiation of an effective anti-tumor T-cell immune response. However, cancer-derived immune suppressive factors render the tumor-draining lymph nodes (TDLN) immune compromised, enabling tumors to invade and metastasize. Unraveling the different mechanisms underlying this immune escape will inform therapeutic intervention strategies to halt tumor spread in early clinical stages. Here, we review our findings from translational studies in melanoma, breast, and cervical cancer and discuss clinical opportunities for local immune modulation of TDLN in each of these indications.",
author = "Jossie Rotman and Koster, {Bas D.} and Jordanova, {Ekaterina S.} and Heeren, {A. Marijne} and {de Gruijl}, {Tanja D.}",
year = "2019",
doi = "10.1007/s00262-019-02330-y",
language = "English",
journal = "Cancer Immunology and Immunotherapy",
issn = "0340-7004",
publisher = "Springer Science and Business Media Deutschland GmbH",

}

TY - JOUR

T1 - Unlocking the therapeutic potential of primary tumor-draining lymph nodes

AU - Rotman, Jossie

AU - Koster, Bas D.

AU - Jordanova, Ekaterina S.

AU - Heeren, A. Marijne

AU - de Gruijl, Tanja D.

PY - 2019

Y1 - 2019

N2 - Lymph nodes draining the primary tumor are essential for the initiation of an effective anti-tumor T-cell immune response. However, cancer-derived immune suppressive factors render the tumor-draining lymph nodes (TDLN) immune compromised, enabling tumors to invade and metastasize. Unraveling the different mechanisms underlying this immune escape will inform therapeutic intervention strategies to halt tumor spread in early clinical stages. Here, we review our findings from translational studies in melanoma, breast, and cervical cancer and discuss clinical opportunities for local immune modulation of TDLN in each of these indications.

AB - Lymph nodes draining the primary tumor are essential for the initiation of an effective anti-tumor T-cell immune response. However, cancer-derived immune suppressive factors render the tumor-draining lymph nodes (TDLN) immune compromised, enabling tumors to invade and metastasize. Unraveling the different mechanisms underlying this immune escape will inform therapeutic intervention strategies to halt tumor spread in early clinical stages. Here, we review our findings from translational studies in melanoma, breast, and cervical cancer and discuss clinical opportunities for local immune modulation of TDLN in each of these indications.

UR - https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85064506208&origin=inward

UR - https://www.ncbi.nlm.nih.gov/pubmed/30944963

U2 - 10.1007/s00262-019-02330-y

DO - 10.1007/s00262-019-02330-y

M3 - Review article

JO - Cancer Immunology and Immunotherapy

JF - Cancer Immunology and Immunotherapy

SN - 0340-7004

ER -