Unmet medical needs in pulmonary neuroendocrine (Carcinoid) neoplasms

Eric Baudin, Aimee R. Hayes, Jean-Yves Scoazec, Pier Luigi Filosso, Eric Lim, Gregory Kaltsas, Andrea Frilling, Jie Chen, Beata Kos-Kudła, Vera Gorbunova, Bertram Wiedenmann, Els Nieveen van Dijkum, Jaroslaw B. Cwikła, Jenny Falkerby, Juan W. Valle, Matthew H. Kulke, Martyn E. Caplin

Research output: Contribution to journalArticleAcademicpeer-review

Abstract

Pulmonary carcinoids (PCs) display the common features of all well-differentiated neuroendocrine neoplasms (NEN) and are classified as low- A nd intermediate-grade malignant tumours (i.e., typical and atypical carcinoid, respectively). There is a paucity of randomised studies dedicated to advanced PCs and management principles are drawn from the larger gastroenteropancreatic NEN experience. There is growing evidence that NEN anatomic subgroups have different biology and different responses to treatment and, therefore, should be investigated as separate entities in clinical trials. In this review, we discuss the existing evidence and limitations of tumour classification, diagnostics and staging, prognostication, and treatment in the setting of PC, with focus on unmet medical needs and directions for the future.
Original languageEnglish
Pages (from-to)7-17
JournalNeuroendocrinology
Volume108
Issue number1
DOIs
Publication statusPublished - 1 Jan 2019
Externally publishedYes

Cite this

Baudin, E., Hayes, A. R., Scoazec, J-Y., Filosso, P. L., Lim, E., Kaltsas, G., ... Caplin, M. E. (2019). Unmet medical needs in pulmonary neuroendocrine (Carcinoid) neoplasms. Neuroendocrinology, 108(1), 7-17. https://doi.org/10.1159/000493980