Uterine artery embolization vs hysterectomy in the treatment of symptomatic uterine fibroids: 5-year outcome from the randomized EMMY trial

Sanne M van der Kooij; Wouter J K Hehenkamp; Nicole A Volkers; Erwin Birnie; Willem M Ankum; Jim A Reekers

doi:10.1016/j.ajog.2010.01.049

Uterine artery embolization vs hysterectomy in the treatment of symptomatic uterine fibroids: 5-year outcome from the randomized EMMY trial

Sanne M van der Kooij, Wouter J K Hehenkamp, Nicole A Volkers, Erwin Birnie, Willem M Ankum, Jim A Reekers

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

OBJECTIVE: The purpose of this study was to compare clinical outcome and health related quality of life (HRQOL) 5 years after uterine artery embolization (UAE) or hysterectomy in the treatment of menorrhagia caused by uterine fibroids.

STUDY DESIGN: Patients with symptomatic uterine fibroids who were eligible for hysterectomy were assigned randomly 1:1 to hysterectomy or UAE. Endpoints after 5 years were reintervention rates, menorrhagia, and HRQOL measures that were assessed by validated questionnaires.

RESULTS: Patients were assigned randomly to UAE (n = 88) or hysterectomy (n = 89). Five years after treatment 23 of 81 UAE patients (28.4%) had undergone a hysterectomy because of insufficient improvement of complaints (24.7% after successful UAE). HRQOL measures improved significantly and remained stable until the 5-year follow-up evaluation, with no differences between the groups. UAE had a positive effect both on urinary and defecation function.

CONCLUSION: UAE is a well-established alternative to hysterectomy about which patients should be counseled.

Original language	English
Pages (from-to)	105.e1-13
Journal	American Journal of Obstetrics and Gynecology
Volume	203
Issue number	2
DOIs	https://doi.org/10.1016/j.ajog.2010.01.049
Publication status	Published - Aug 2010

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10.1016/j.ajog.2010.01.049

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@article{c95dd44d76e041cc9eddb601f97cf16f,

title = "Uterine artery embolization vs hysterectomy in the treatment of symptomatic uterine fibroids: 5-year outcome from the randomized EMMY trial",

abstract = "OBJECTIVE: The purpose of this study was to compare clinical outcome and health related quality of life (HRQOL) 5 years after uterine artery embolization (UAE) or hysterectomy in the treatment of menorrhagia caused by uterine fibroids.STUDY DESIGN: Patients with symptomatic uterine fibroids who were eligible for hysterectomy were assigned randomly 1:1 to hysterectomy or UAE. Endpoints after 5 years were reintervention rates, menorrhagia, and HRQOL measures that were assessed by validated questionnaires.RESULTS: Patients were assigned randomly to UAE (n = 88) or hysterectomy (n = 89). Five years after treatment 23 of 81 UAE patients (28.4%) had undergone a hysterectomy because of insufficient improvement of complaints (24.7% after successful UAE). HRQOL measures improved significantly and remained stable until the 5-year follow-up evaluation, with no differences between the groups. UAE had a positive effect both on urinary and defecation function.CONCLUSION: UAE is a well-established alternative to hysterectomy about which patients should be counseled.",

keywords = "Adult, Female, Follow-Up Studies, Humans, Hysterectomy/adverse effects, Hysterectomy, Vaginal/adverse effects, Kaplan-Meier Estimate, Leiomyoma/pathology, Middle Aged, Neoplasm Staging, Pain Measurement, Pain, Postoperative/physiopathology, Patient Satisfaction, Postoperative Complications/epidemiology, Prospective Studies, Quality of Life, Risk Assessment, Statistics, Nonparametric, Time Factors, Treatment Outcome, Uterine Artery Embolization/adverse effects, Uterine Neoplasms/pathology",

author = "{van der Kooij}, {Sanne M} and Hehenkamp, {Wouter J K} and Volkers, {Nicole A} and Erwin Birnie and Ankum, {Willem M} and Reekers, {Jim A}",

year = "2010",

month = aug,

doi = "10.1016/j.ajog.2010.01.049",

language = "English",

volume = "203",

pages = "105.e1--13",

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Uterine artery embolization vs hysterectomy in the treatment of symptomatic uterine fibroids : 5-year outcome from the randomized EMMY trial. / van der Kooij, Sanne M; Hehenkamp, Wouter J K; Volkers, Nicole A et al.

In: American Journal of Obstetrics and Gynecology, Vol. 203, No. 2, 08.2010, p. 105.e1-13.

Research output: Contribution to journal › Article › Academic › peer-review

TY - JOUR

T1 - Uterine artery embolization vs hysterectomy in the treatment of symptomatic uterine fibroids

T2 - 5-year outcome from the randomized EMMY trial

AU - van der Kooij, Sanne M

AU - Hehenkamp, Wouter J K

AU - Volkers, Nicole A

AU - Birnie, Erwin

AU - Ankum, Willem M

AU - Reekers, Jim A

PY - 2010/8

Y1 - 2010/8

N2 - OBJECTIVE: The purpose of this study was to compare clinical outcome and health related quality of life (HRQOL) 5 years after uterine artery embolization (UAE) or hysterectomy in the treatment of menorrhagia caused by uterine fibroids.STUDY DESIGN: Patients with symptomatic uterine fibroids who were eligible for hysterectomy were assigned randomly 1:1 to hysterectomy or UAE. Endpoints after 5 years were reintervention rates, menorrhagia, and HRQOL measures that were assessed by validated questionnaires.RESULTS: Patients were assigned randomly to UAE (n = 88) or hysterectomy (n = 89). Five years after treatment 23 of 81 UAE patients (28.4%) had undergone a hysterectomy because of insufficient improvement of complaints (24.7% after successful UAE). HRQOL measures improved significantly and remained stable until the 5-year follow-up evaluation, with no differences between the groups. UAE had a positive effect both on urinary and defecation function.CONCLUSION: UAE is a well-established alternative to hysterectomy about which patients should be counseled.

AB - OBJECTIVE: The purpose of this study was to compare clinical outcome and health related quality of life (HRQOL) 5 years after uterine artery embolization (UAE) or hysterectomy in the treatment of menorrhagia caused by uterine fibroids.STUDY DESIGN: Patients with symptomatic uterine fibroids who were eligible for hysterectomy were assigned randomly 1:1 to hysterectomy or UAE. Endpoints after 5 years were reintervention rates, menorrhagia, and HRQOL measures that were assessed by validated questionnaires.RESULTS: Patients were assigned randomly to UAE (n = 88) or hysterectomy (n = 89). Five years after treatment 23 of 81 UAE patients (28.4%) had undergone a hysterectomy because of insufficient improvement of complaints (24.7% after successful UAE). HRQOL measures improved significantly and remained stable until the 5-year follow-up evaluation, with no differences between the groups. UAE had a positive effect both on urinary and defecation function.CONCLUSION: UAE is a well-established alternative to hysterectomy about which patients should be counseled.

KW - Adult

KW - Female

KW - Follow-Up Studies

KW - Humans

KW - Hysterectomy/adverse effects

KW - Hysterectomy, Vaginal/adverse effects

KW - Kaplan-Meier Estimate

KW - Leiomyoma/pathology

KW - Middle Aged

KW - Neoplasm Staging

KW - Pain Measurement

KW - Pain, Postoperative/physiopathology

KW - Patient Satisfaction

KW - Postoperative Complications/epidemiology

KW - Prospective Studies

KW - Quality of Life

KW - Risk Assessment

KW - Statistics, Nonparametric

KW - Time Factors

KW - Treatment Outcome

KW - Uterine Artery Embolization/adverse effects

KW - Uterine Neoplasms/pathology

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DO - 10.1016/j.ajog.2010.01.049

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SN - 0002-9378

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SP - 105.e1-13

JO - American Journal of Obstetrics and Gynecology

JF - American Journal of Obstetrics and Gynecology

IS - 2

ER -