TY - JOUR
T1 - Vaccine-induced effector-memory CD8+ T cell responses predict therapeutic efficacy against tumors
AU - van Duikeren, Suzanne
AU - Fransen, Marieke F.
AU - Redeker, Anke
AU - Wieles, Brigitte
AU - Platenburg, Gerard
AU - Krebber, Willem-Jan
AU - Ossendorp, Ferry
AU - Melief, Cornelis J. M.
AU - Arens, Ramon
PY - 2012
Y1 - 2012
N2 - CD8+ T cells have the potential to attack and eradicate cancer cells. The efficacy of therapeutic vaccines against cancer, however, lacks defined immune correlates of tumor eradication after (therapeutic) vaccination based on features of Ag-specific T cell responses. In this study, we examined CD8+ T cell responses elicited by various peptide and TLR agonist-based vaccine formulations in nontumor settings and show that the formation of CD62L-KLRG1+ effector-memory CD8+ T cells producing the effector cytokines IFN-γ and TNF predicts the degree of therapeutic efficacy of these vaccines against established s.c. tumors. Thus, characteristics of vaccine-induced CD8+ T cell responses instill a predictive determinant for the efficacy of vaccines during tumor therapy. Copyright © 2012 by The American Association of Immunologists, Inc.
AB - CD8+ T cells have the potential to attack and eradicate cancer cells. The efficacy of therapeutic vaccines against cancer, however, lacks defined immune correlates of tumor eradication after (therapeutic) vaccination based on features of Ag-specific T cell responses. In this study, we examined CD8+ T cell responses elicited by various peptide and TLR agonist-based vaccine formulations in nontumor settings and show that the formation of CD62L-KLRG1+ effector-memory CD8+ T cells producing the effector cytokines IFN-γ and TNF predicts the degree of therapeutic efficacy of these vaccines against established s.c. tumors. Thus, characteristics of vaccine-induced CD8+ T cell responses instill a predictive determinant for the efficacy of vaccines during tumor therapy. Copyright © 2012 by The American Association of Immunologists, Inc.
UR - https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84866551579&origin=inward
UR - https://www.ncbi.nlm.nih.gov/pubmed/22914049
U2 - 10.4049/jimmunol.1201540
DO - 10.4049/jimmunol.1201540
M3 - Article
C2 - 22914049
VL - 189
SP - 3397
EP - 3403
JO - Journal of Immunology
JF - Journal of Immunology
SN - 0022-1767
IS - 7
ER -