Value of a comprehensive geriatric assessment for predicting one-year outcomes in patients undergoing transcatheter aortic valve implantation: Results from the CGA-TAVI multicentre registry

Martijn S. Van Mourik, Nathalie Van Der Velde, Giulio Mannarino, Marie Pierre Thibodeau, Jean Bernard Masson, Gennaro Santoro, Jan Baan, Sofie Jansen, Jana Kurucova, Martin Thoenes, Cornelia Deutsch, Andreas W. Schoenenberger, Andrea Ungar, Peter Bramlage, M. Marije Vis*

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

Abstract

Background In a three-month report from the CGA-TAVI registry, we found the Multidimensional Prognostic Index (MPI) and Short Physical Performance Battery (SPPB) to be of value for predicting short-term outcomes in elderly patients undergoing transcatheter aortic valve implantation (TAVI). In the present analysis, we examined the association of these tools with outcomes up to one year post-TAVI. Methods CGA-TAVI is an international, observational registry of geriatric patients undergoing TAVI. Patients were assessed using the MPI and SPPB. Efficacy of baseline values and any postoperative change for predicting outcome were established using logistic regression. Kap-lan-Meier analysis was carried out for each comprehensive geriatric assessment tool, with survival stratified by risk category. Results One year after TAVI, 14.1% of patients deceased, while 17.4% met the combined endpoint of death and/or non-fatal stroke, and 37.7% the combined endpoint of death and/or hospitalisation and/or non-fatal stroke. A high-risk MPI score was associated with an increased risk of all-cause mortality (aOR = 36.13, 95% CI: 2.77-470.78, P = 0.006) and death and/or non-fatal stroke (aOR = 10.10, 95% CI: 1.48-68.75, P = 0.018). No significant associations were found between a high-risk SPPB score and mortality or two main combined endpoints. In contrast to a worsening SPPB, an aggravating MPI score at three months post-TAVI was associated with an increased risk of death and/or non-fatal stoke at one year (aOR = 95.16, 95% CI: 3.41-2657.01). Conclusions The MPI showed value for predicting the likelihood of death and a combination of death and/or non-fatal stroke by one year after TAVI in elderly patients.

Original languageEnglish
Pages (from-to)468-477
Number of pages10
JournalJournal of Geriatric Cardiology
Volume16
Issue number6
DOIs
Publication statusPublished - 1 Jan 2019
Externally publishedYes

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