Objective: To determine the value of health-related quality of life (HRQoL) to predict change in disability status in patients with multiple sclerosis (MS). Methods: Over a 5-year period, data were collected on HRQoL (Medical Outcomes Study Short Form-36 Health Survey) and disability status (Expanded Disability Status Scale) from a heterogeneous group of 81 Dutch-speaking patients with MS. Results: Multivariate logistic regression analysis showed that HRQoL in the domains of Physical Functioning and Role-Physical Functioning is a significant predictor of change in disability status. Conclusions: A patient's subjectively perceived health-related quality of life may not be only a clinically and psychosocially meaningful outcome per se but may also be a predictor of objective outcomes such as change in disability status over a substantial period of time.
|Number of pages||5|
|Publication status||Published - 14 Dec 2004|
Visschedijk, M. A. J., Uitdehaag, B. M. J., Klein, M., Van Der Ploeg, E., Collette, E. H., Vleugels, L., ... Polman, C. H. (2004). Value of health-related quality of life to predict disability course in multiple sclerosis. Neurology, 63(11), 2046-2050. https://doi.org/10.1212/01.WNL.0000145769.51420.ED