Value of health-related quality of life to predict disability course in multiple sclerosis

M. A.J. Visschedijk, B. M.J. Uitdehaag, M. Klein, E. Van Der Ploeg, E. H. Collette, L. Vleugels, L. E.M.A. Pfennings, E. L.J. Hoogervorst, H. M. Van Der Ploeg, C. H. Polman

Research output: Contribution to journalArticleAcademicpeer-review

Abstract

Objective: To determine the value of health-related quality of life (HRQoL) to predict change in disability status in patients with multiple sclerosis (MS). Methods: Over a 5-year period, data were collected on HRQoL (Medical Outcomes Study Short Form-36 Health Survey) and disability status (Expanded Disability Status Scale) from a heterogeneous group of 81 Dutch-speaking patients with MS. Results: Multivariate logistic regression analysis showed that HRQoL in the domains of Physical Functioning and Role-Physical Functioning is a significant predictor of change in disability status. Conclusions: A patient's subjectively perceived health-related quality of life may not be only a clinically and psychosocially meaningful outcome per se but may also be a predictor of objective outcomes such as change in disability status over a substantial period of time.
Original languageEnglish
Pages (from-to)2046-2050
Number of pages5
JournalNeurology
Volume63
Issue number11
DOIs
Publication statusPublished - 14 Dec 2004

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