Various strategies to improve efficacy of stem cell transplantation in multiple sclerosis: Focus on mesenchymal stem cells and neuroprotection

Forouzan Yousefi, Fahimeh Lavi Arab, Kolsoum Saeidi, Houshang Amiri, Mahmoud Mahmoudi

Research output: Contribution to journalReview articleAcademicpeer-review

Abstract

Multiple sclerosis (MS) is an inflammatory demyelinating disease of the central nervous system (CNS) which predominantly affect young adults and undergo heavy socioeconomic burdens. Conventional therapeutic modalities for MS mostly downregulate aggressive immune responses and are almost insufficient for management of progressive course of the disease. Mesenchymal stem cells (MSCs), due to both immunomodulatory and neuroprotective properties have been known as practical cells for treatment of neurodegenerative diseases like MS. However, clinical translation of MSCs is associated with some limitations such as short-life engraftment duration, little in vivo trans-differentiation and restricted accessibility into damaged sites. Therefore, laboratory manipulation of MSCs can improve efficacy of MSCs transplantation in MS patients. In this review, we discuss several novel approaches, which can potentially enhance MSCs capabilities for treating MS.
Original languageEnglish
Pages (from-to)20-34
JournalJournal of Neuroimmunology
Volume328
DOIs
Publication statusPublished - 2019

Cite this

Yousefi, Forouzan ; Lavi Arab, Fahimeh ; Saeidi, Kolsoum ; Amiri, Houshang ; Mahmoudi, Mahmoud. / Various strategies to improve efficacy of stem cell transplantation in multiple sclerosis: Focus on mesenchymal stem cells and neuroprotection. In: Journal of Neuroimmunology. 2019 ; Vol. 328. pp. 20-34.
@article{6473557161ff48ec8dc0bddc04c9c80e,
title = "Various strategies to improve efficacy of stem cell transplantation in multiple sclerosis: Focus on mesenchymal stem cells and neuroprotection",
abstract = "Multiple sclerosis (MS) is an inflammatory demyelinating disease of the central nervous system (CNS) which predominantly affect young adults and undergo heavy socioeconomic burdens. Conventional therapeutic modalities for MS mostly downregulate aggressive immune responses and are almost insufficient for management of progressive course of the disease. Mesenchymal stem cells (MSCs), due to both immunomodulatory and neuroprotective properties have been known as practical cells for treatment of neurodegenerative diseases like MS. However, clinical translation of MSCs is associated with some limitations such as short-life engraftment duration, little in vivo trans-differentiation and restricted accessibility into damaged sites. Therefore, laboratory manipulation of MSCs can improve efficacy of MSCs transplantation in MS patients. In this review, we discuss several novel approaches, which can potentially enhance MSCs capabilities for treating MS.",
author = "Forouzan Yousefi and {Lavi Arab}, Fahimeh and Kolsoum Saeidi and Houshang Amiri and Mahmoud Mahmoudi",
year = "2019",
doi = "10.1016/j.jneuroim.2018.11.015",
language = "English",
volume = "328",
pages = "20--34",
journal = "Journal of Neuroimmunology",
issn = "0165-5728",
publisher = "Elsevier",

}

Various strategies to improve efficacy of stem cell transplantation in multiple sclerosis: Focus on mesenchymal stem cells and neuroprotection. / Yousefi, Forouzan; Lavi Arab, Fahimeh; Saeidi, Kolsoum; Amiri, Houshang; Mahmoudi, Mahmoud.

In: Journal of Neuroimmunology, Vol. 328, 2019, p. 20-34.

Research output: Contribution to journalReview articleAcademicpeer-review

TY - JOUR

T1 - Various strategies to improve efficacy of stem cell transplantation in multiple sclerosis: Focus on mesenchymal stem cells and neuroprotection

AU - Yousefi, Forouzan

AU - Lavi Arab, Fahimeh

AU - Saeidi, Kolsoum

AU - Amiri, Houshang

AU - Mahmoudi, Mahmoud

PY - 2019

Y1 - 2019

N2 - Multiple sclerosis (MS) is an inflammatory demyelinating disease of the central nervous system (CNS) which predominantly affect young adults and undergo heavy socioeconomic burdens. Conventional therapeutic modalities for MS mostly downregulate aggressive immune responses and are almost insufficient for management of progressive course of the disease. Mesenchymal stem cells (MSCs), due to both immunomodulatory and neuroprotective properties have been known as practical cells for treatment of neurodegenerative diseases like MS. However, clinical translation of MSCs is associated with some limitations such as short-life engraftment duration, little in vivo trans-differentiation and restricted accessibility into damaged sites. Therefore, laboratory manipulation of MSCs can improve efficacy of MSCs transplantation in MS patients. In this review, we discuss several novel approaches, which can potentially enhance MSCs capabilities for treating MS.

AB - Multiple sclerosis (MS) is an inflammatory demyelinating disease of the central nervous system (CNS) which predominantly affect young adults and undergo heavy socioeconomic burdens. Conventional therapeutic modalities for MS mostly downregulate aggressive immune responses and are almost insufficient for management of progressive course of the disease. Mesenchymal stem cells (MSCs), due to both immunomodulatory and neuroprotective properties have been known as practical cells for treatment of neurodegenerative diseases like MS. However, clinical translation of MSCs is associated with some limitations such as short-life engraftment duration, little in vivo trans-differentiation and restricted accessibility into damaged sites. Therefore, laboratory manipulation of MSCs can improve efficacy of MSCs transplantation in MS patients. In this review, we discuss several novel approaches, which can potentially enhance MSCs capabilities for treating MS.

UR - https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85058404325&origin=inward

UR - https://www.ncbi.nlm.nih.gov/pubmed/30557687

U2 - 10.1016/j.jneuroim.2018.11.015

DO - 10.1016/j.jneuroim.2018.11.015

M3 - Review article

VL - 328

SP - 20

EP - 34

JO - Journal of Neuroimmunology

JF - Journal of Neuroimmunology

SN - 0165-5728

ER -