TY - JOUR
T1 - Various strategies to improve efficacy of stem cell transplantation in multiple sclerosis: Focus on mesenchymal stem cells and neuroprotection
AU - Yousefi, Forouzan
AU - Lavi Arab, Fahimeh
AU - Saeidi, Kolsoum
AU - Amiri, Houshang
AU - Mahmoudi, Mahmoud
PY - 2019
Y1 - 2019
N2 - Multiple sclerosis (MS) is an inflammatory demyelinating disease of the central nervous system (CNS) which predominantly affect young adults and undergo heavy socioeconomic burdens. Conventional therapeutic modalities for MS mostly downregulate aggressive immune responses and are almost insufficient for management of progressive course of the disease. Mesenchymal stem cells (MSCs), due to both immunomodulatory and neuroprotective properties have been known as practical cells for treatment of neurodegenerative diseases like MS. However, clinical translation of MSCs is associated with some limitations such as short-life engraftment duration, little in vivo trans-differentiation and restricted accessibility into damaged sites. Therefore, laboratory manipulation of MSCs can improve efficacy of MSCs transplantation in MS patients. In this review, we discuss several novel approaches, which can potentially enhance MSCs capabilities for treating MS.
AB - Multiple sclerosis (MS) is an inflammatory demyelinating disease of the central nervous system (CNS) which predominantly affect young adults and undergo heavy socioeconomic burdens. Conventional therapeutic modalities for MS mostly downregulate aggressive immune responses and are almost insufficient for management of progressive course of the disease. Mesenchymal stem cells (MSCs), due to both immunomodulatory and neuroprotective properties have been known as practical cells for treatment of neurodegenerative diseases like MS. However, clinical translation of MSCs is associated with some limitations such as short-life engraftment duration, little in vivo trans-differentiation and restricted accessibility into damaged sites. Therefore, laboratory manipulation of MSCs can improve efficacy of MSCs transplantation in MS patients. In this review, we discuss several novel approaches, which can potentially enhance MSCs capabilities for treating MS.
KW - Mesenchymal stem cell
KW - Multiple sclerosis
KW - Neuroprotection
KW - Stem cell transplantation
UR - https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85058404325&origin=inward
UR - https://www.ncbi.nlm.nih.gov/pubmed/30557687
U2 - 10.1016/j.jneuroim.2018.11.015
DO - 10.1016/j.jneuroim.2018.11.015
M3 - Review article
C2 - 30557687
SN - 0165-5728
VL - 328
SP - 20
EP - 34
JO - Journal of Neuroimmunology
JF - Journal of Neuroimmunology
ER -