TY - JOUR
T1 - Vascular risk factors are associated with longitudinal changes in cerebrospinal fluid tau markers and cognition in preclinical Alzheimer's disease
AU - Bos, Isabelle
AU - Vos, Stephanie J. B.
AU - Schindler, Suzanne E.
AU - Hassenstab, J.
AU - Xiong, Chengjie
AU - Grant, Elizabeth
AU - Verhey, F.
AU - Morris, John C.
AU - Visser, Pieter Jelle
AU - Fagan, Anne M.
PY - 2019/9/1
Y1 - 2019/9/1
N2 - Introduction: Vascular factors increase the risk of Alzheimer's disease (AD). We investigated the associations between such factors, longitudinal AD cerebrospinal fluid biomarkers, and cognition. Methods: 433 cognitively normal participants were classified into four biomarker groups using their baseline amyloid (A+/−) and tau status (T+/−). 184 participants had undergone serial cerebrospinal fluid collection. Frequencies of risk factors and the Framingham Risk Score (FRS) were compared, and we tested the influence of risk factors on change in biomarker concentrations and cognition. Results: The absence of obesity, presence of hypertension, and a high FRS were associated with an increase in tau levels, particularly in A+T+ individuals. Risk factors were not associated with amyloid. Depression was associated with higher cognitive scores, whereas high FRS was associated with lower scores and a faster decline. Discussion: Our results demonstrate that vascular risk factors may enhance neurodegeneration but not amyloid accumulation in preclinical AD.
AB - Introduction: Vascular factors increase the risk of Alzheimer's disease (AD). We investigated the associations between such factors, longitudinal AD cerebrospinal fluid biomarkers, and cognition. Methods: 433 cognitively normal participants were classified into four biomarker groups using their baseline amyloid (A+/−) and tau status (T+/−). 184 participants had undergone serial cerebrospinal fluid collection. Frequencies of risk factors and the Framingham Risk Score (FRS) were compared, and we tested the influence of risk factors on change in biomarker concentrations and cognition. Results: The absence of obesity, presence of hypertension, and a high FRS were associated with an increase in tau levels, particularly in A+T+ individuals. Risk factors were not associated with amyloid. Depression was associated with higher cognitive scores, whereas high FRS was associated with lower scores and a faster decline. Discussion: Our results demonstrate that vascular risk factors may enhance neurodegeneration but not amyloid accumulation in preclinical AD.
KW - Alzheimer's disease
KW - Amyloid-β
KW - Biomarkers
KW - Cardiovascular disorders
KW - Cerebrospinal fluid
KW - Dementia
KW - Depression
KW - Framingham Risk Score
KW - Hypercholesterolemia
KW - Hypertension
KW - Neurodegeneration
KW - Obesity
KW - Tau
KW - Vascular risk factors
UR - https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85069973707&origin=inward
UR - https://www.ncbi.nlm.nih.gov/pubmed/31378575
U2 - 10.1016/j.jalz.2019.04.015
DO - 10.1016/j.jalz.2019.04.015
M3 - Article
C2 - 31378575
VL - 15
SP - 1149
EP - 1159
JO - Alzheimers & Dementia
JF - Alzheimers & Dementia
SN - 1552-5260
IS - 9
ER -