Vitamin D and Mortality: Anticancer Research

S. Pilz, M. Grubler, M. Gaksch, V. Schwetz, C. Trummer, Briain O. Hartaigh, N. Verheyen, A. Tomaschitz, W. Marz

Research output: Contribution to journalReview articleAcademicpeer-review


In this narrative review, we aim to summarize and discuss the current evidence linking vitamin D and mortality. Low 25-hydroxyvitamin D [25(OH)D] concentrations are associated with an increased risk of mortality. This has been shown in different cohort studies including general populations, as well as various patient cohorts. Some single-study results and meta-analyses indicate that the shape of the relationship between 25(OH)D and mortality follows a U-or a reverse J-shaped curve. Interassay and laboratory differences are, however, a limitation of most previous surveys, and standardization of 25(OH)D measurements is needed for future investigations. Apart from observational data, it has been documented in meta-analyses of randomized controlled trials that vitamin D3 supplementation is associated with a moderate, yet statistically significant, reduction in mortality. This latter finding must be interpreted in light of some limitations such as incomplete follow-up data, but such a reduction of mortality with vitamin D3 supplementation as the finding of meta-analyses of randomized controlled trials strongly argues for the benefits and, importantly, also the safety of vitamin D.
Original languageEnglish
Pages (from-to)1379-1387
Number of pages9
JournalAnticancer Research
Publication statusPublished - 2016

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