Vitamin D and Mortality: Anticancer Research

S. Pilz, M. Grubler, M. Gaksch, V. Schwetz, C. Trummer, Briain O. Hartaigh, N. Verheyen, A. Tomaschitz, W. Marz

Research output: Contribution to journalReview articleAcademicpeer-review

Abstract

In this narrative review, we aim to summarize and discuss the current evidence linking vitamin D and mortality. Low 25-hydroxyvitamin D [25(OH)D] concentrations are associated with an increased risk of mortality. This has been shown in different cohort studies including general populations, as well as various patient cohorts. Some single-study results and meta-analyses indicate that the shape of the relationship between 25(OH)D and mortality follows a U-or a reverse J-shaped curve. Interassay and laboratory differences are, however, a limitation of most previous surveys, and standardization of 25(OH)D measurements is needed for future investigations. Apart from observational data, it has been documented in meta-analyses of randomized controlled trials that vitamin D3 supplementation is associated with a moderate, yet statistically significant, reduction in mortality. This latter finding must be interpreted in light of some limitations such as incomplete follow-up data, but such a reduction of mortality with vitamin D3 supplementation as the finding of meta-analyses of randomized controlled trials strongly argues for the benefits and, importantly, also the safety of vitamin D.
Original languageEnglish
Pages (from-to)1379-1387
Number of pages9
JournalAnticancer Research
Volume36
Publication statusPublished - 2016

Cite this

Pilz, S., Grubler, M., Gaksch, M., Schwetz, V., Trummer, C., Hartaigh, B. O., ... Marz, W. (2016). Vitamin D and Mortality: Anticancer Research. Anticancer Research, 36, 1379-1387.
Pilz, S. ; Grubler, M. ; Gaksch, M. ; Schwetz, V. ; Trummer, C. ; Hartaigh, Briain O. ; Verheyen, N. ; Tomaschitz, A. ; Marz, W. / Vitamin D and Mortality : Anticancer Research. In: Anticancer Research. 2016 ; Vol. 36. pp. 1379-1387.
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abstract = "In this narrative review, we aim to summarize and discuss the current evidence linking vitamin D and mortality. Low 25-hydroxyvitamin D [25(OH)D] concentrations are associated with an increased risk of mortality. This has been shown in different cohort studies including general populations, as well as various patient cohorts. Some single-study results and meta-analyses indicate that the shape of the relationship between 25(OH)D and mortality follows a U-or a reverse J-shaped curve. Interassay and laboratory differences are, however, a limitation of most previous surveys, and standardization of 25(OH)D measurements is needed for future investigations. Apart from observational data, it has been documented in meta-analyses of randomized controlled trials that vitamin D3 supplementation is associated with a moderate, yet statistically significant, reduction in mortality. This latter finding must be interpreted in light of some limitations such as incomplete follow-up data, but such a reduction of mortality with vitamin D3 supplementation as the finding of meta-analyses of randomized controlled trials strongly argues for the benefits and, importantly, also the safety of vitamin D.",
author = "S. Pilz and M. Grubler and M. Gaksch and V. Schwetz and C. Trummer and Hartaigh, {Briain O.} and N. Verheyen and A. Tomaschitz and W. Marz",
note = "M1 - 3 ISI Document Delivery No.: DL2DW Times Cited: 4 Cited Reference Count: 95 Pilz, Stefan Gruebler, Martin Gaksch, Martin Schwetz, Verena Trummer, Christian Hartaigh, Briain O. Verheyen, Nicolas Tomaschitz, Andreas Maerz, Winfried International Symposium on Biologic Effects of Light JUN 11-12, 2015 Homburg, GERMANY Grubler, Martin R./0000-0002-1761-2914 4 5 6 INT INST ANTICANCER RESEARCH ATHENS ANTICANCER RES",
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Pilz, S, Grubler, M, Gaksch, M, Schwetz, V, Trummer, C, Hartaigh, BO, Verheyen, N, Tomaschitz, A & Marz, W 2016, 'Vitamin D and Mortality: Anticancer Research' Anticancer Research, vol. 36, pp. 1379-1387.

Vitamin D and Mortality : Anticancer Research. / Pilz, S.; Grubler, M.; Gaksch, M.; Schwetz, V.; Trummer, C.; Hartaigh, Briain O.; Verheyen, N.; Tomaschitz, A.; Marz, W.

In: Anticancer Research, Vol. 36, 2016, p. 1379-1387.

Research output: Contribution to journalReview articleAcademicpeer-review

TY - JOUR

T1 - Vitamin D and Mortality

T2 - Anticancer Research

AU - Pilz, S.

AU - Grubler, M.

AU - Gaksch, M.

AU - Schwetz, V.

AU - Trummer, C.

AU - Hartaigh, Briain O.

AU - Verheyen, N.

AU - Tomaschitz, A.

AU - Marz, W.

N1 - M1 - 3 ISI Document Delivery No.: DL2DW Times Cited: 4 Cited Reference Count: 95 Pilz, Stefan Gruebler, Martin Gaksch, Martin Schwetz, Verena Trummer, Christian Hartaigh, Briain O. Verheyen, Nicolas Tomaschitz, Andreas Maerz, Winfried International Symposium on Biologic Effects of Light JUN 11-12, 2015 Homburg, GERMANY Grubler, Martin R./0000-0002-1761-2914 4 5 6 INT INST ANTICANCER RESEARCH ATHENS ANTICANCER RES

PY - 2016

Y1 - 2016

N2 - In this narrative review, we aim to summarize and discuss the current evidence linking vitamin D and mortality. Low 25-hydroxyvitamin D [25(OH)D] concentrations are associated with an increased risk of mortality. This has been shown in different cohort studies including general populations, as well as various patient cohorts. Some single-study results and meta-analyses indicate that the shape of the relationship between 25(OH)D and mortality follows a U-or a reverse J-shaped curve. Interassay and laboratory differences are, however, a limitation of most previous surveys, and standardization of 25(OH)D measurements is needed for future investigations. Apart from observational data, it has been documented in meta-analyses of randomized controlled trials that vitamin D3 supplementation is associated with a moderate, yet statistically significant, reduction in mortality. This latter finding must be interpreted in light of some limitations such as incomplete follow-up data, but such a reduction of mortality with vitamin D3 supplementation as the finding of meta-analyses of randomized controlled trials strongly argues for the benefits and, importantly, also the safety of vitamin D.

AB - In this narrative review, we aim to summarize and discuss the current evidence linking vitamin D and mortality. Low 25-hydroxyvitamin D [25(OH)D] concentrations are associated with an increased risk of mortality. This has been shown in different cohort studies including general populations, as well as various patient cohorts. Some single-study results and meta-analyses indicate that the shape of the relationship between 25(OH)D and mortality follows a U-or a reverse J-shaped curve. Interassay and laboratory differences are, however, a limitation of most previous surveys, and standardization of 25(OH)D measurements is needed for future investigations. Apart from observational data, it has been documented in meta-analyses of randomized controlled trials that vitamin D3 supplementation is associated with a moderate, yet statistically significant, reduction in mortality. This latter finding must be interpreted in light of some limitations such as incomplete follow-up data, but such a reduction of mortality with vitamin D3 supplementation as the finding of meta-analyses of randomized controlled trials strongly argues for the benefits and, importantly, also the safety of vitamin D.

M3 - Review article

VL - 36

SP - 1379

EP - 1387

JO - Anticancer Research

JF - Anticancer Research

SN - 0250-7005

ER -

Pilz S, Grubler M, Gaksch M, Schwetz V, Trummer C, Hartaigh BO et al. Vitamin D and Mortality: Anticancer Research. Anticancer Research. 2016;36:1379-1387.