Vitamin K Dependent Proteins in Kidney Disease

Ciprian N. Silaghi, Tamás Ilyés, Vladimir P. Filip, Marius Farcaș, Adriana J. van Ballegooijen, Alexandra M. Crăciun

Research output: Contribution to journalReview articleAcademicpeer-review

Abstract

Patients with chronic kidney disease (CKD) have an increased risk of developing vascular calcifications, as well as bone dynamics impairment, leading to a poor quality of life and increased mortality. Certain vitamin K dependent proteins (VKDPs) act mainly as calcification inhibitors, but their involvement in the onset and progression of CKD are not completely elucidated. This review is an update of the current state of knowledge about the relationship between CKD and four extrahepatic VKDPs: matrix Gla protein, osteocalcin, growth-arrest specific protein 6 and Gla-rich protein. Based on published literature in the last ten years, the purpose of this review is to address fundamental aspects about the link between CKD and circulating VKDPs levels as well as to raise new topics about how the interplay between molecular weight and charge could influence the modifications of circulating VKDPs at the glomerular level, or whether distinct renal etiologies have effect on VKDPs. This review is the output of a systematic literature search and may open future research avenues in this niche domain.
Original languageEnglish
JournalInternational Journal of Molecular Sciences
Volume20
Issue number7
DOIs
Publication statusPublished - 2019

Cite this

Silaghi, Ciprian N. ; Ilyés, Tamás ; Filip, Vladimir P. ; Farcaș, Marius ; van Ballegooijen, Adriana J. ; Crăciun, Alexandra M. / Vitamin K Dependent Proteins in Kidney Disease. In: International Journal of Molecular Sciences. 2019 ; Vol. 20, No. 7.
@article{59ce4e818ec841269167b900c488d698,
title = "Vitamin K Dependent Proteins in Kidney Disease",
abstract = "Patients with chronic kidney disease (CKD) have an increased risk of developing vascular calcifications, as well as bone dynamics impairment, leading to a poor quality of life and increased mortality. Certain vitamin K dependent proteins (VKDPs) act mainly as calcification inhibitors, but their involvement in the onset and progression of CKD are not completely elucidated. This review is an update of the current state of knowledge about the relationship between CKD and four extrahepatic VKDPs: matrix Gla protein, osteocalcin, growth-arrest specific protein 6 and Gla-rich protein. Based on published literature in the last ten years, the purpose of this review is to address fundamental aspects about the link between CKD and circulating VKDPs levels as well as to raise new topics about how the interplay between molecular weight and charge could influence the modifications of circulating VKDPs at the glomerular level, or whether distinct renal etiologies have effect on VKDPs. This review is the output of a systematic literature search and may open future research avenues in this niche domain.",
keywords = "Vitamin K dependent proteins, matrix Gla protein, osteocalcin, Gas6, Gla-rich protein, chronic kidney disease, calcification",
author = "Silaghi, {Ciprian N.} and Tam{\'a}s Ily{\'e}s and Filip, {Vladimir P.} and Marius Farcaș and {van Ballegooijen}, {Adriana J.} and Crăciun, {Alexandra M.}",
year = "2019",
doi = "10.3390/ijms20071571",
language = "English",
volume = "20",
journal = "International Journal of Molecular Sciences",
issn = "1422-0067",
publisher = "Multidisciplinary Digital Publishing Institute (MDPI)",
number = "7",

}

Vitamin K Dependent Proteins in Kidney Disease. / Silaghi, Ciprian N.; Ilyés, Tamás; Filip, Vladimir P.; Farcaș, Marius; van Ballegooijen, Adriana J.; Crăciun, Alexandra M.

In: International Journal of Molecular Sciences, Vol. 20, No. 7, 2019.

Research output: Contribution to journalReview articleAcademicpeer-review

TY - JOUR

T1 - Vitamin K Dependent Proteins in Kidney Disease

AU - Silaghi, Ciprian N.

AU - Ilyés, Tamás

AU - Filip, Vladimir P.

AU - Farcaș, Marius

AU - van Ballegooijen, Adriana J.

AU - Crăciun, Alexandra M.

PY - 2019

Y1 - 2019

N2 - Patients with chronic kidney disease (CKD) have an increased risk of developing vascular calcifications, as well as bone dynamics impairment, leading to a poor quality of life and increased mortality. Certain vitamin K dependent proteins (VKDPs) act mainly as calcification inhibitors, but their involvement in the onset and progression of CKD are not completely elucidated. This review is an update of the current state of knowledge about the relationship between CKD and four extrahepatic VKDPs: matrix Gla protein, osteocalcin, growth-arrest specific protein 6 and Gla-rich protein. Based on published literature in the last ten years, the purpose of this review is to address fundamental aspects about the link between CKD and circulating VKDPs levels as well as to raise new topics about how the interplay between molecular weight and charge could influence the modifications of circulating VKDPs at the glomerular level, or whether distinct renal etiologies have effect on VKDPs. This review is the output of a systematic literature search and may open future research avenues in this niche domain.

AB - Patients with chronic kidney disease (CKD) have an increased risk of developing vascular calcifications, as well as bone dynamics impairment, leading to a poor quality of life and increased mortality. Certain vitamin K dependent proteins (VKDPs) act mainly as calcification inhibitors, but their involvement in the onset and progression of CKD are not completely elucidated. This review is an update of the current state of knowledge about the relationship between CKD and four extrahepatic VKDPs: matrix Gla protein, osteocalcin, growth-arrest specific protein 6 and Gla-rich protein. Based on published literature in the last ten years, the purpose of this review is to address fundamental aspects about the link between CKD and circulating VKDPs levels as well as to raise new topics about how the interplay between molecular weight and charge could influence the modifications of circulating VKDPs at the glomerular level, or whether distinct renal etiologies have effect on VKDPs. This review is the output of a systematic literature search and may open future research avenues in this niche domain.

KW - Vitamin K dependent proteins

KW - matrix Gla protein

KW - osteocalcin

KW - Gas6

KW - Gla-rich protein

KW - chronic kidney disease

KW - calcification

UR - https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85064214217&origin=inward

UR - https://www.ncbi.nlm.nih.gov/pubmed/30934817

U2 - 10.3390/ijms20071571

DO - 10.3390/ijms20071571

M3 - Review article

VL - 20

JO - International Journal of Molecular Sciences

JF - International Journal of Molecular Sciences

SN - 1422-0067

IS - 7

ER -