Vitamin K is no antagonist for the action of warfarin in rat osteosarcoma UMR 106

M. M.W. Ulrich, M. H.J. Knapen, M. P.M. Herrmann Erlee, C. Vermeer*

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

Abstract

The recycling of vitamin K in the liver occurs via one or two dithiol-dependent reductases, which are strongly inhibited by coumarin derivatives such as warfarin. This inhibition may be partly overcome by the action of a NADU-dependent reductase, which is relatively insensitive for warfarin. In this paper we demonstrate that the osteoblast-like osteosarcoma UMR 106 does not contain the NADH-dependent reductase. Assuming that a similar enzyme distribution occurs in normal osteoblasts this explains the observation of Price and Kaneda [8], that the administration of vitamin K to rats efficiently counteracted the effect of warfarin on blood coagulation, but that the vitamin had no effect on the Gla-content of serum osteocalcin.

Original languageEnglish
Pages (from-to)27-32
Number of pages6
JournalThrombosis Research
Volume50
Issue number1
DOIs
Publication statusPublished - 1 Apr 1988

Cite this