WAPL-Dependent Repair of Damaged DNA Replication Forks Underlies Oncogene-Induced Loss of Sister Chromatid Cohesion

Bente Benedict, Janne J.M. van Schie, Anneke B. Oostra, Jesper A. Balk, Rob M.F. Wolthuis*, Hein te Riele, Job de Lange

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review


Benedict et al. show that in cancer cells the connection between newly synthesized chromatids (cohesion) is often less tight than in normal cells. They show that removal of cohesion in cancer cells is necessary to repair broken DNA replication forks and to sustain tumor cell expansion.

Original languageEnglish
Pages (from-to)683-698.e7
JournalDevelopmental Cell
Issue number6
Publication statusPublished - 23 Mar 2020

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