White-matter changes on MRI as surrogate marker

Philip Scheltens*, Frederik Barkhof, Franz Fazekas

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review


This article reviews the use of white-matter changes as identified on MRI as a surrogate marker in clinical trials on vascular dementia. As of yet, insufficient evidence is present to implement rating or volumetric assessment of the burden of white-matter changes as surrogate marker in such trials, in view of the limited sensitivity to change of current methods and the high measurement error.

Original languageEnglish
Pages (from-to)261-265
Number of pages5
JournalInternational Psychogeriatrics
Issue numberSUPPL. 1
Publication statusPublished - 7 Oct 2003

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