Abstract

PD-L1 immunohistochemistry correlates only moderately with patient survival and response to PD-(L)1 treatment. Heterogeneity of tumor PD-L1 expression might limit the predictive value of small biopsies. Here we show that tumor PD-L1 and PD-1 expression can be quantified non-invasively using PET-CT in patients with non-small-cell lung cancer. Whole body PD-(L)1 PET-CT reveals significant tumor tracer uptake heterogeneity both between patients, as well as within patients between different tumor lesions.

Original languageEnglish
Article number4664
JournalNature Communications
Volume9
Issue number1
DOIs
Publication statusPublished - 1 Dec 2018

Cite this

@article{d30ba1b7b39a4b97808bb3aafc2cb645,
title = "Whole body PD-1 and PD-L1 positron emission tomography in patients with non-small-cell lung cancer",
abstract = "PD-L1 immunohistochemistry correlates only moderately with patient survival and response to PD-(L)1 treatment. Heterogeneity of tumor PD-L1 expression might limit the predictive value of small biopsies. Here we show that tumor PD-L1 and PD-1 expression can be quantified non-invasively using PET-CT in patients with non-small-cell lung cancer. Whole body PD-(L)1 PET-CT reveals significant tumor tracer uptake heterogeneity both between patients, as well as within patients between different tumor lesions.",
author = "Niemeijer, {A. N.} and D. Leung and Huisman, {M. C.} and I. Bahce and Hoekstra, {O. S.} and {van Dongen}, {G. A.M.S.} and R. Boellaard and S. Du and W. Hayes and R. Smith and Windhorst, {A. D.} and Hendrikse, {N. H.} and A. Poot and Vugts, {D. J.} and E. Thunnissen and P. Morin and D. Lipovsek and Donnelly, {D. J.} and Bonacorsi, {S. J.} and Velasquez, {L. M.} and {de Gruijl}, {T. D.} and Smit, {E. F.} and {de Langen}, {A. J.}",
year = "2018",
month = "12",
day = "1",
doi = "10.1038/s41467-018-07131-y",
language = "English",
volume = "9",
journal = "Nature Communications",
issn = "2041-1723",
number = "1",

}

Whole body PD-1 and PD-L1 positron emission tomography in patients with non-small-cell lung cancer. / Niemeijer, A. N.; Leung, D.; Huisman, M. C.; Bahce, I.; Hoekstra, O. S.; van Dongen, G. A.M.S.; Boellaard, R.; Du, S.; Hayes, W.; Smith, R.; Windhorst, A. D.; Hendrikse, N. H.; Poot, A.; Vugts, D. J.; Thunnissen, E.; Morin, P.; Lipovsek, D.; Donnelly, D. J.; Bonacorsi, S. J.; Velasquez, L. M.; de Gruijl, T. D.; Smit, E. F.; de Langen, A. J.

In: Nature Communications, Vol. 9, No. 1, 4664, 01.12.2018.

Research output: Contribution to journalArticleAcademicpeer-review

TY - JOUR

T1 - Whole body PD-1 and PD-L1 positron emission tomography in patients with non-small-cell lung cancer

AU - Niemeijer, A. N.

AU - Leung, D.

AU - Huisman, M. C.

AU - Bahce, I.

AU - Hoekstra, O. S.

AU - van Dongen, G. A.M.S.

AU - Boellaard, R.

AU - Du, S.

AU - Hayes, W.

AU - Smith, R.

AU - Windhorst, A. D.

AU - Hendrikse, N. H.

AU - Poot, A.

AU - Vugts, D. J.

AU - Thunnissen, E.

AU - Morin, P.

AU - Lipovsek, D.

AU - Donnelly, D. J.

AU - Bonacorsi, S. J.

AU - Velasquez, L. M.

AU - de Gruijl, T. D.

AU - Smit, E. F.

AU - de Langen, A. J.

PY - 2018/12/1

Y1 - 2018/12/1

N2 - PD-L1 immunohistochemistry correlates only moderately with patient survival and response to PD-(L)1 treatment. Heterogeneity of tumor PD-L1 expression might limit the predictive value of small biopsies. Here we show that tumor PD-L1 and PD-1 expression can be quantified non-invasively using PET-CT in patients with non-small-cell lung cancer. Whole body PD-(L)1 PET-CT reveals significant tumor tracer uptake heterogeneity both between patients, as well as within patients between different tumor lesions.

AB - PD-L1 immunohistochemistry correlates only moderately with patient survival and response to PD-(L)1 treatment. Heterogeneity of tumor PD-L1 expression might limit the predictive value of small biopsies. Here we show that tumor PD-L1 and PD-1 expression can be quantified non-invasively using PET-CT in patients with non-small-cell lung cancer. Whole body PD-(L)1 PET-CT reveals significant tumor tracer uptake heterogeneity both between patients, as well as within patients between different tumor lesions.

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U2 - 10.1038/s41467-018-07131-y

DO - 10.1038/s41467-018-07131-y

M3 - Article

VL - 9

JO - Nature Communications

JF - Nature Communications

SN - 2041-1723

IS - 1

M1 - 4664

ER -