Whole-brain T1 mapping in multiple sclerosis: Global changes of normal-appearing gray and white matter

Hugo Vrenken, Jeroen J G Geurts, Dirk L. Knol, L. Noor Van Dijk, Vincenzo Dattola, Bas Jasperse, Ronald A. Van Schijndel, Chris H. Polman, Jonas A. Castelijns, Frederik Barkhof, Petra J W Pouwels

Research output: Contribution to journalArticleAcademicpeer-review

Abstract

Purpose: To prospectively investigate whether T1 changes in normal-appearing white matter (WM) and normal-appearing gray matter (GM) in multiple sclerosis (MS) are global or regional and their relationship to disease type. Materials and Methods: The institutional ethics review board approved study; written informed consent was obtained. Whole-brain T1 maps were obtained in 67 patients with MS and 24 healthy control subjects with three-dimensional fast low-angle shot flip angle-array method, with correction for B1 imperfections. Analysis of variance was performed on T1 histogram parameters of global normal-appearing WM and GM. Regional mean T1 values were analyzed with a multilevel approach. Multiple linear regression analysis was performed to investigate associations with clinical disability and overall atrophy. For patients, T2 lesion load was determined. Results: T1 histograms of normal-appearing WM had significantly higher peak positions for patients with MS (792 msec ± 36 in secondary progressive [SP] MS) than for control subjects (746 msec ± 23) and were significantly broader and lower (all P < .001). Histograms for cortical normal-appearing GM were significantly shifted (peak positions, 1263 msec ± 44 in control subjects and 1355 msec ± 62 in patients with SP MS) (P < .001). Histogram peak positions were significantly higher in SP MS than in relapsing-remitting (RR) and primary progressive MS (P < .05). In SP disease, at least 31% of normal-appearing WM and 20% of cortical normal-appearing GM were affected. In MS, T1 was significantly elevated in all normal-appearing WM and cortical normal-appearing GM regions (all P < .01) but was elevated only in the thalamus in deep GM (P < .05). Cortical T1 histogram peak position was associated with clinical disability; T2 lesion load was not. Conclusion: Results suggest that a global disease process affects large parts of both normal-appearing WM and GM in MS and effects are worse for SP MS than for RR MS.

Original languageEnglish
Pages (from-to)811-820
Number of pages10
JournalRadiology
Volume240
Issue number3
DOIs
Publication statusPublished - 1 Sep 2006

Cite this

@article{eb0c4433cd754e318f777cc61d9cdb93,
title = "Whole-brain T1 mapping in multiple sclerosis: Global changes of normal-appearing gray and white matter",
abstract = "Purpose: To prospectively investigate whether T1 changes in normal-appearing white matter (WM) and normal-appearing gray matter (GM) in multiple sclerosis (MS) are global or regional and their relationship to disease type. Materials and Methods: The institutional ethics review board approved study; written informed consent was obtained. Whole-brain T1 maps were obtained in 67 patients with MS and 24 healthy control subjects with three-dimensional fast low-angle shot flip angle-array method, with correction for B1 imperfections. Analysis of variance was performed on T1 histogram parameters of global normal-appearing WM and GM. Regional mean T1 values were analyzed with a multilevel approach. Multiple linear regression analysis was performed to investigate associations with clinical disability and overall atrophy. For patients, T2 lesion load was determined. Results: T1 histograms of normal-appearing WM had significantly higher peak positions for patients with MS (792 msec ± 36 in secondary progressive [SP] MS) than for control subjects (746 msec ± 23) and were significantly broader and lower (all P < .001). Histograms for cortical normal-appearing GM were significantly shifted (peak positions, 1263 msec ± 44 in control subjects and 1355 msec ± 62 in patients with SP MS) (P < .001). Histogram peak positions were significantly higher in SP MS than in relapsing-remitting (RR) and primary progressive MS (P < .05). In SP disease, at least 31{\%} of normal-appearing WM and 20{\%} of cortical normal-appearing GM were affected. In MS, T1 was significantly elevated in all normal-appearing WM and cortical normal-appearing GM regions (all P < .01) but was elevated only in the thalamus in deep GM (P < .05). Cortical T1 histogram peak position was associated with clinical disability; T2 lesion load was not. Conclusion: Results suggest that a global disease process affects large parts of both normal-appearing WM and GM in MS and effects are worse for SP MS than for RR MS.",
author = "Hugo Vrenken and Geurts, {Jeroen J G} and Knol, {Dirk L.} and {Noor Van Dijk}, L. and Vincenzo Dattola and Bas Jasperse and {Van Schijndel}, {Ronald A.} and Polman, {Chris H.} and Castelijns, {Jonas A.} and Frederik Barkhof and Pouwels, {Petra J W}",
year = "2006",
month = "9",
day = "1",
doi = "10.1148/radiol.2403050569",
language = "English",
volume = "240",
pages = "811--820",
journal = "Radiology Now",
issn = "0033-8419",
publisher = "Radiological Society of North America Inc.",
number = "3",

}

Whole-brain T1 mapping in multiple sclerosis : Global changes of normal-appearing gray and white matter. / Vrenken, Hugo; Geurts, Jeroen J G; Knol, Dirk L.; Noor Van Dijk, L.; Dattola, Vincenzo; Jasperse, Bas; Van Schijndel, Ronald A.; Polman, Chris H.; Castelijns, Jonas A.; Barkhof, Frederik; Pouwels, Petra J W.

In: Radiology, Vol. 240, No. 3, 01.09.2006, p. 811-820.

Research output: Contribution to journalArticleAcademicpeer-review

TY - JOUR

T1 - Whole-brain T1 mapping in multiple sclerosis

T2 - Global changes of normal-appearing gray and white matter

AU - Vrenken, Hugo

AU - Geurts, Jeroen J G

AU - Knol, Dirk L.

AU - Noor Van Dijk, L.

AU - Dattola, Vincenzo

AU - Jasperse, Bas

AU - Van Schijndel, Ronald A.

AU - Polman, Chris H.

AU - Castelijns, Jonas A.

AU - Barkhof, Frederik

AU - Pouwels, Petra J W

PY - 2006/9/1

Y1 - 2006/9/1

N2 - Purpose: To prospectively investigate whether T1 changes in normal-appearing white matter (WM) and normal-appearing gray matter (GM) in multiple sclerosis (MS) are global or regional and their relationship to disease type. Materials and Methods: The institutional ethics review board approved study; written informed consent was obtained. Whole-brain T1 maps were obtained in 67 patients with MS and 24 healthy control subjects with three-dimensional fast low-angle shot flip angle-array method, with correction for B1 imperfections. Analysis of variance was performed on T1 histogram parameters of global normal-appearing WM and GM. Regional mean T1 values were analyzed with a multilevel approach. Multiple linear regression analysis was performed to investigate associations with clinical disability and overall atrophy. For patients, T2 lesion load was determined. Results: T1 histograms of normal-appearing WM had significantly higher peak positions for patients with MS (792 msec ± 36 in secondary progressive [SP] MS) than for control subjects (746 msec ± 23) and were significantly broader and lower (all P < .001). Histograms for cortical normal-appearing GM were significantly shifted (peak positions, 1263 msec ± 44 in control subjects and 1355 msec ± 62 in patients with SP MS) (P < .001). Histogram peak positions were significantly higher in SP MS than in relapsing-remitting (RR) and primary progressive MS (P < .05). In SP disease, at least 31% of normal-appearing WM and 20% of cortical normal-appearing GM were affected. In MS, T1 was significantly elevated in all normal-appearing WM and cortical normal-appearing GM regions (all P < .01) but was elevated only in the thalamus in deep GM (P < .05). Cortical T1 histogram peak position was associated with clinical disability; T2 lesion load was not. Conclusion: Results suggest that a global disease process affects large parts of both normal-appearing WM and GM in MS and effects are worse for SP MS than for RR MS.

AB - Purpose: To prospectively investigate whether T1 changes in normal-appearing white matter (WM) and normal-appearing gray matter (GM) in multiple sclerosis (MS) are global or regional and their relationship to disease type. Materials and Methods: The institutional ethics review board approved study; written informed consent was obtained. Whole-brain T1 maps were obtained in 67 patients with MS and 24 healthy control subjects with three-dimensional fast low-angle shot flip angle-array method, with correction for B1 imperfections. Analysis of variance was performed on T1 histogram parameters of global normal-appearing WM and GM. Regional mean T1 values were analyzed with a multilevel approach. Multiple linear regression analysis was performed to investigate associations with clinical disability and overall atrophy. For patients, T2 lesion load was determined. Results: T1 histograms of normal-appearing WM had significantly higher peak positions for patients with MS (792 msec ± 36 in secondary progressive [SP] MS) than for control subjects (746 msec ± 23) and were significantly broader and lower (all P < .001). Histograms for cortical normal-appearing GM were significantly shifted (peak positions, 1263 msec ± 44 in control subjects and 1355 msec ± 62 in patients with SP MS) (P < .001). Histogram peak positions were significantly higher in SP MS than in relapsing-remitting (RR) and primary progressive MS (P < .05). In SP disease, at least 31% of normal-appearing WM and 20% of cortical normal-appearing GM were affected. In MS, T1 was significantly elevated in all normal-appearing WM and cortical normal-appearing GM regions (all P < .01) but was elevated only in the thalamus in deep GM (P < .05). Cortical T1 histogram peak position was associated with clinical disability; T2 lesion load was not. Conclusion: Results suggest that a global disease process affects large parts of both normal-appearing WM and GM in MS and effects are worse for SP MS than for RR MS.

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U2 - 10.1148/radiol.2403050569

DO - 10.1148/radiol.2403050569

M3 - Article

VL - 240

SP - 811

EP - 820

JO - Radiology Now

JF - Radiology Now

SN - 0033-8419

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