Whole-genome sequencing identifies EN1 as a determinant of bone density and fracture

H.F. Zheng; V. Forgetta; Y.H. Hsu; K. Estrada; A. Rosello-Diez; P.J. Leo; C.L. Dahia; K.H. Park-Min; J.H. Tobias; C. Kooperberg; A. Kleinman; U. Styrkarsdottir; C.T. Liu; C. Uggla; D.S. Evans; C.M. Nielson; K. Walter; U. Pettersson-Kymmer; S. McCarthy; J. Eriksson; T. Kwan; M. Jhamai; K. Trajanoska; Y. Memari; J. Min; J. Huang; P. Danecek; B. Wilmot; R. Li; W.C. Chou; L.E. Mokry; A. Moayyeri; M. Claussnitzer; C.H. Cheng; W. Cheung; C. Medina-Gomez; B. Ge; S.H. Chen; K. Choi; L. Oei; J. Fraser; R. Kraaij; M.A. Hibbs; C.L. Gregson; D. Paquette; A. Hofman; C. Wibom; G.J. Tranah; M. Marshall; B.B. Gardiner; K. Cremin; P. Auer; L. Hsu; S. Ring; J.Y. Tung; G. Thorleifsson; A.W. Enneman; N.M. van Schoor; L.C.P.G. de Groot; N. van der Velde; B. Melin; J.P. Kemp; C. Christiansen; A. Sayers; Y.H. Zhou; S. Calderari; J. van Rooij; C. Carlson; U. Peters; S. Berlivet; J. Dostie; A. G. Uitterlinden; S.R. Williams; C. Farber; D. Grinberg; A.Z. LaCroix; J. Haessler; D.I. Chasman; F. Giulianini; L.M. Rose; P.M. Ridker; J.A. Eisman; T.V. Nguyen; J.R. Center; X. Nogues; N. Garcia-Giralt; L.L. Launer; V. Gudnason; D. Mellstrom; L. Vandenput; N. Amin; C.M. van Duijn; M.K. Karlsson; O. Ljunggren; O. Svensson; G. Hallmans; F. Rousseau; S. Giroux; J. Bussiere; F.F. Rivadeneira; J.B. Richards

doi:10.1038/nature14878

Whole-genome sequencing identifies EN1 as a determinant of bone density and fracture

H.F. Zheng, V. Forgetta, Y.H. Hsu, K. Estrada, A. Rosello-Diez, P.J. Leo, C.L. Dahia, K.H. Park-Min, J.H. Tobias, C. Kooperberg, A. Kleinman, U. Styrkarsdottir, C.T. Liu, C. Uggla, D.S. Evans, C.M. Nielson, K. Walter, U. Pettersson-Kymmer, S. McCarthy, J. ErikssonT. Kwan, M. Jhamai, K. Trajanoska, Y. Memari, J. Min, J. Huang, P. Danecek, B. Wilmot, R. Li, W.C. Chou, L.E. Mokry, A. Moayyeri, M. Claussnitzer, C.H. Cheng, W. Cheung, C. Medina-Gomez, B. Ge, S.H. Chen, K. Choi, L. Oei, J. Fraser, R. Kraaij, M.A. Hibbs, C.L. Gregson, D. Paquette, A. Hofman, C. Wibom, G.J. Tranah, M. Marshall, B.B. Gardiner, K. Cremin, P. Auer, L. Hsu, S. Ring, J.Y. Tung, G. Thorleifsson, A.W. Enneman, N.M. van Schoor, L.C.P.G. de Groot, N. van der Velde, B. Melin, J.P. Kemp, C. Christiansen, A. Sayers, Y.H. Zhou, S. Calderari, J. van Rooij, C. Carlson, U. Peters, S. Berlivet, J. Dostie, A. G. Uitterlinden, S.R. Williams, C. Farber, D. Grinberg, A.Z. LaCroix, J. Haessler, D.I. Chasman, F. Giulianini, L.M. Rose, P.M. Ridker, J.A. Eisman, T.V. Nguyen, J.R. Center, X. Nogues, N. Garcia-Giralt, L.L. Launer, V. Gudnason, D. Mellstrom, L. Vandenput, N. Amin, C.M. van Duijn, M.K. Karlsson, O. Ljunggren, O. Svensson, G. Hallmans, F. Rousseau, S. Giroux, J. Bussiere, F.F. Rivadeneira, J.B. Richards

Epidemiology and biostatistics

Research output: Contribution to journal › Article › Academic › peer-review

Original language	Undefined/Unknown
Pages (from-to)	112-117
Journal	Nature
Volume	526
Issue number	7571
DOIs	https://doi.org/10.1038/nature14878
Publication status	Published - 2015

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10.1038/nature14878

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Zheng, H. F., Forgetta, V., Hsu, Y. H., Estrada, K., Rosello-Diez, A., Leo, P. J., Dahia, C. L., Park-Min, K. H., Tobias, J. H., Kooperberg, C., Kleinman, A., Styrkarsdottir, U., Liu, C. T., Uggla, C., Evans, D. S., Nielson, C. M., Walter, K., Pettersson-Kymmer, U., McCarthy, S., ... Richards, J. B. (2015). Whole-genome sequencing identifies EN1 as a determinant of bone density and fracture. Nature, 526(7571), 112-117. https://doi.org/10.1038/nature14878

Zheng, H.F. ; Forgetta, V. ; Hsu, Y.H. ; Estrada, K. ; Rosello-Diez, A. ; Leo, P.J. ; Dahia, C.L. ; Park-Min, K.H. ; Tobias, J.H. ; Kooperberg, C. ; Kleinman, A. ; Styrkarsdottir, U. ; Liu, C.T. ; Uggla, C. ; Evans, D.S. ; Nielson, C.M. ; Walter, K. ; Pettersson-Kymmer, U. ; McCarthy, S. ; Eriksson, J. ; Kwan, T. ; Jhamai, M. ; Trajanoska, K. ; Memari, Y. ; Min, J. ; Huang, J. ; Danecek, P. ; Wilmot, B. ; Li, R. ; Chou, W.C. ; Mokry, L.E. ; Moayyeri, A. ; Claussnitzer, M. ; Cheng, C.H. ; Cheung, W. ; Medina-Gomez, C. ; Ge, B. ; Chen, S.H. ; Choi, K. ; Oei, L. ; Fraser, J. ; Kraaij, R. ; Hibbs, M.A. ; Gregson, C.L. ; Paquette, D. ; Hofman, A. ; Wibom, C. ; Tranah, G.J. ; Marshall, M. ; Gardiner, B.B. ; Cremin, K. ; Auer, P. ; Hsu, L. ; Ring, S. ; Tung, J.Y. ; Thorleifsson, G. ; Enneman, A.W. ; van Schoor, N.M. ; de Groot, L.C.P.G. ; van der Velde, N. ; Melin, B. ; Kemp, J.P. ; Christiansen, C. ; Sayers, A. ; Zhou, Y.H. ; Calderari, S. ; van Rooij, J. ; Carlson, C. ; Peters, U. ; Berlivet, S. ; Dostie, J. ; Uitterlinden, A. G. ; Williams, S.R. ; Farber, C. ; Grinberg, D. ; LaCroix, A.Z. ; Haessler, J. ; Chasman, D.I. ; Giulianini, F. ; Rose, L.M. ; Ridker, P.M. ; Eisman, J.A. ; Nguyen, T.V. ; Center, J.R. ; Nogues, X. ; Garcia-Giralt, N. ; Launer, L.L. ; Gudnason, V. ; Mellstrom, D. ; Vandenput, L. ; Amin, N. ; van Duijn, C.M. ; Karlsson, M.K. ; Ljunggren, O. ; Svensson, O. ; Hallmans, G. ; Rousseau, F. ; Giroux, S. ; Bussiere, J. ; Rivadeneira, F.F. ; Richards, J.B. / Whole-genome sequencing identifies EN1 as a determinant of bone density and fracture. In: Nature. 2015 ; Vol. 526, No. 7571. pp. 112-117.

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title = "Whole-genome sequencing identifies EN1 as a determinant of bone density and fracture",

author = "H.F. Zheng and V. Forgetta and Y.H. Hsu and K. Estrada and A. Rosello-Diez and P.J. Leo and C.L. Dahia and K.H. Park-Min and J.H. Tobias and C. Kooperberg and A. Kleinman and U. Styrkarsdottir and C.T. Liu and C. Uggla and D.S. Evans and C.M. Nielson and K. Walter and U. Pettersson-Kymmer and S. McCarthy and J. Eriksson and T. Kwan and M. Jhamai and K. Trajanoska and Y. Memari and J. Min and J. Huang and P. Danecek and B. Wilmot and R. Li and W.C. Chou and L.E. Mokry and A. Moayyeri and M. Claussnitzer and C.H. Cheng and W. Cheung and C. Medina-Gomez and B. Ge and S.H. Chen and K. Choi and L. Oei and J. Fraser and R. Kraaij and M.A. Hibbs and C.L. Gregson and D. Paquette and A. Hofman and C. Wibom and G.J. Tranah and M. Marshall and B.B. Gardiner and K. Cremin and P. Auer and L. Hsu and S. Ring and J.Y. Tung and G. Thorleifsson and A.W. Enneman and {van Schoor}, N.M. and {de Groot}, L.C.P.G. and {van der Velde}, N. and B. Melin and J.P. Kemp and C. Christiansen and A. Sayers and Y.H. Zhou and S. Calderari and {van Rooij}, J. and C. Carlson and U. Peters and S. Berlivet and J. Dostie and Uitterlinden, {A. G.} and S.R. Williams and C. Farber and D. Grinberg and A.Z. LaCroix and J. Haessler and D.I. Chasman and F. Giulianini and L.M. Rose and P.M. Ridker and J.A. Eisman and T.V. Nguyen and J.R. Center and X. Nogues and N. Garcia-Giralt and L.L. Launer and V. Gudnason and D. Mellstrom and L. Vandenput and N. Amin and {van Duijn}, C.M. and M.K. Karlsson and O. Ljunggren and O. Svensson and G. Hallmans and F. Rousseau and S. Giroux and J. Bussiere and F.F. Rivadeneira and J.B. Richards",

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doi = "10.1038/nature14878",

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volume = "526",

pages = "112--117",

journal = "Nature",

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Zheng, HF, Forgetta, V, Hsu, YH, Estrada, K, Rosello-Diez, A, Leo, PJ, Dahia, CL, Park-Min, KH, Tobias, JH, Kooperberg, C, Kleinman, A, Styrkarsdottir, U, Liu, CT, Uggla, C, Evans, DS, Nielson, CM, Walter, K, Pettersson-Kymmer, U, McCarthy, S, Eriksson, J, Kwan, T, Jhamai, M, Trajanoska, K, Memari, Y, Min, J, Huang, J, Danecek, P, Wilmot, B, Li, R, Chou, WC, Mokry, LE, Moayyeri, A, Claussnitzer, M, Cheng, CH, Cheung, W, Medina-Gomez, C, Ge, B, Chen, SH, Choi, K, Oei, L, Fraser, J, Kraaij, R, Hibbs, MA, Gregson, CL, Paquette, D, Hofman, A, Wibom, C, Tranah, GJ, Marshall, M, Gardiner, BB, Cremin, K, Auer, P, Hsu, L, Ring, S, Tung, JY, Thorleifsson, G, Enneman, AW, van Schoor, NM, de Groot, LCPG, van der Velde, N, Melin, B, Kemp, JP, Christiansen, C, Sayers, A, Zhou, YH, Calderari, S, van Rooij, J, Carlson, C, Peters, U, Berlivet, S, Dostie, J, Uitterlinden, AG, Williams, SR, Farber, C, Grinberg, D, LaCroix, AZ, Haessler, J, Chasman, DI, Giulianini, F, Rose, LM, Ridker, PM, Eisman, JA, Nguyen, TV, Center, JR, Nogues, X, Garcia-Giralt, N, Launer, LL, Gudnason, V, Mellstrom, D, Vandenput, L, Amin, N, van Duijn, CM, Karlsson, MK, Ljunggren, O, Svensson, O, Hallmans, G, Rousseau, F, Giroux, S, Bussiere, J, Rivadeneira, FF & Richards, JB 2015, 'Whole-genome sequencing identifies EN1 as a determinant of bone density and fracture', Nature, vol. 526, no. 7571, pp. 112-117. https://doi.org/10.1038/nature14878

Whole-genome sequencing identifies EN1 as a determinant of bone density and fracture. / Zheng, H.F.; Forgetta, V.; Hsu, Y.H.; Estrada, K.; Rosello-Diez, A.; Leo, P.J.; Dahia, C.L.; Park-Min, K.H.; Tobias, J.H.; Kooperberg, C.; Kleinman, A.; Styrkarsdottir, U.; Liu, C.T.; Uggla, C.; Evans, D.S.; Nielson, C.M.; Walter, K.; Pettersson-Kymmer, U.; McCarthy, S.; Eriksson, J.; Kwan, T.; Jhamai, M.; Trajanoska, K.; Memari, Y.; Min, J.; Huang, J.; Danecek, P.; Wilmot, B.; Li, R.; Chou, W.C.; Mokry, L.E.; Moayyeri, A.; Claussnitzer, M.; Cheng, C.H.; Cheung, W.; Medina-Gomez, C.; Ge, B.; Chen, S.H.; Choi, K.; Oei, L.; Fraser, J.; Kraaij, R.; Hibbs, M.A.; Gregson, C.L.; Paquette, D.; Hofman, A.; Wibom, C.; Tranah, G.J.; Marshall, M.; Gardiner, B.B.; Cremin, K.; Auer, P.; Hsu, L.; Ring, S.; Tung, J.Y.; Thorleifsson, G.; Enneman, A.W.; van Schoor, N.M.; de Groot, L.C.P.G.; van der Velde, N.; Melin, B.; Kemp, J.P.; Christiansen, C.; Sayers, A.; Zhou, Y.H.; Calderari, S.; van Rooij, J.; Carlson, C.; Peters, U.; Berlivet, S.; Dostie, J.; Uitterlinden, A. G.; Williams, S.R.; Farber, C.; Grinberg, D.; LaCroix, A.Z.; Haessler, J.; Chasman, D.I.; Giulianini, F.; Rose, L.M.; Ridker, P.M.; Eisman, J.A.; Nguyen, T.V.; Center, J.R.; Nogues, X.; Garcia-Giralt, N.; Launer, L.L.; Gudnason, V.; Mellstrom, D.; Vandenput, L.; Amin, N.; van Duijn, C.M.; Karlsson, M.K.; Ljunggren, O.; Svensson, O.; Hallmans, G.; Rousseau, F.; Giroux, S.; Bussiere, J.; Rivadeneira, F.F.; Richards, J.B.

In: Nature, Vol. 526, No. 7571, 2015, p. 112-117.

Research output: Contribution to journal › Article › Academic › peer-review

TY - JOUR

T1 - Whole-genome sequencing identifies EN1 as a determinant of bone density and fracture

AU - Zheng, H.F.

AU - Forgetta, V.

AU - Hsu, Y.H.

AU - Estrada, K.

AU - Rosello-Diez, A.

AU - Leo, P.J.

AU - Dahia, C.L.

AU - Park-Min, K.H.

AU - Tobias, J.H.

AU - Kooperberg, C.

AU - Kleinman, A.

AU - Styrkarsdottir, U.

AU - Liu, C.T.

AU - Uggla, C.

AU - Evans, D.S.

AU - Nielson, C.M.

AU - Walter, K.

AU - Pettersson-Kymmer, U.

AU - McCarthy, S.

AU - Eriksson, J.

AU - Kwan, T.

AU - Jhamai, M.

AU - Trajanoska, K.

AU - Memari, Y.

AU - Min, J.

AU - Huang, J.

AU - Danecek, P.

AU - Wilmot, B.

AU - Li, R.

AU - Chou, W.C.

AU - Mokry, L.E.

AU - Moayyeri, A.

AU - Claussnitzer, M.

AU - Cheng, C.H.

AU - Cheung, W.

AU - Medina-Gomez, C.

AU - Ge, B.

AU - Chen, S.H.

AU - Choi, K.

AU - Oei, L.

AU - Fraser, J.

AU - Kraaij, R.

AU - Hibbs, M.A.

AU - Gregson, C.L.

AU - Paquette, D.

AU - Hofman, A.

AU - Wibom, C.

AU - Tranah, G.J.

AU - Marshall, M.

AU - Gardiner, B.B.

AU - Cremin, K.

AU - Auer, P.

AU - Hsu, L.

AU - Ring, S.

AU - Tung, J.Y.

AU - Thorleifsson, G.

AU - Enneman, A.W.

AU - van Schoor, N.M.

AU - de Groot, L.C.P.G.

AU - van der Velde, N.

AU - Melin, B.

AU - Kemp, J.P.

AU - Christiansen, C.

AU - Sayers, A.

AU - Zhou, Y.H.

AU - Calderari, S.

AU - van Rooij, J.

AU - Carlson, C.

AU - Peters, U.

AU - Berlivet, S.

AU - Dostie, J.

AU - Uitterlinden, A. G.

AU - Williams, S.R.

AU - Farber, C.

AU - Grinberg, D.

AU - LaCroix, A.Z.

AU - Haessler, J.

AU - Chasman, D.I.

AU - Giulianini, F.

AU - Rose, L.M.

AU - Ridker, P.M.

AU - Eisman, J.A.

AU - Nguyen, T.V.

AU - Center, J.R.

AU - Nogues, X.

AU - Garcia-Giralt, N.

AU - Launer, L.L.

AU - Gudnason, V.

AU - Mellstrom, D.

AU - Vandenput, L.

AU - Amin, N.

AU - van Duijn, C.M.

AU - Karlsson, M.K.

AU - Ljunggren, O.

AU - Svensson, O.

AU - Hallmans, G.

AU - Rousseau, F.

AU - Giroux, S.

AU - Bussiere, J.

AU - Rivadeneira, F.F.

AU - Richards, J.B.

PY - 2015

Y1 - 2015

U2 - 10.1038/nature14878

DO - 10.1038/nature14878

M3 - Article

C2 - 26367794

VL - 526

SP - 112

EP - 117

JO - Nature

JF - Nature

SN - 0028-0836

IS - 7571

ER -