Why, when and how to assess ischemia and viability in patients with chronic total occlusions

Anna van Veelen, Stefan P. Schumacher, Wijnand J. A. Stuijfzand, José P. S. Henriques, Paul Knaapen

Research output: Chapter in Book/Report/Conference proceedingChapterAcademicpeer-review


Currently, international guidelines recommend the evaluation of ischemic symptoms, as well as the extent of ischemia and the presence of viability, prior to referring patients with stable coronary artery disease, including chronic total occlusion (CTO), for revascularization. A few randomized trials and numerous observational studies have tried to determine the value of ischemia-driven and viability-driven revascularization, but demonstrated contradicting findings. The present review will focus on the current knowledge regarding ischemia and viability testing in patients with a CTO. The evidence and rationale to assess ischemia and viability, next to the clinical workup for CTO revascularization in clinical practice, will be discussed. In addition, an overview of available noninvasive imaging modalities to assess the presence and extent of ischemia and viability will be provided.
Original languageEnglish
Title of host publicationPercutaneous Coronary Intervention for Chronic Total Occlusion: The Hybrid Approach
EditorsStéphane Rinfret
Place of PublicationCham
PublisherSpringer International Publishing
Number of pages16
ISBN (Electronic)9783031054372
ISBN (Print)9783031054365
Publication statusPublished - 23 Nov 2022

Publication series

NamePercutaneous Coronary Intervention for Chronic Total Occlusion: The Hybrid Approach

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